Detection of Early Lung Cancer by Serum Protein Expression Profiling
Conditions
Non-small Cell Lung Cancer
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
Early stage (0/I) non-small cell lung cancer
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
Promising new technology exists to examine small proteins that are shed by cancers into the blood stream. The purpose of this study is to see if there are differences in the proteins and protein levels in blood from individuals with early stage lung cancer compared to healthy adults.
Detailed Description
A prospective longitudinal patient-based pilot study is proposed whereby surfaced enhanced laser desorption ionization time-of-flight mass spectroscopy (SELDI-TOF-MS) will be used to discover and validate serum proteomic expression profiles diagnostic of early lung cancer. A unique approach will be used to compare the serum proteomic expression profiles of patients with non-small cell lung cancer compared to healthy heavy smoking adults, as well as differences before and after anatomic pulmonary resection with curative intent. Discriminatory proteins will be selected by their differential expression before compared to after surgical removal of a tumor. The protein profile of blood obtained from the draining pulmonary vein at the time of resection will be used to identify materials potentially shed by the tumor that may serve as biomarkers in peripheral blood. The serum samples will be used to develop a training data set and then a test set for validation using a class prediction model. Candidate proteomic patterns will then serve as a basis for a larger prospective multi-centre clinical trial.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 75 Years
Minimum Age: 45 Years
Gender: Both
Criteria: Inclusion Criteria:

- Presence of early stage non-small cell lung cancer

- Elective surgical resection of lung lesion at Vancouver General Hospital (VGH)

- No preoperative chemoradiation therapy

- No previous cancer

- Ability to provide informed consent
Location
Vancouver General Hospital BC Cancer Agency
Vancouver, British Columbia, Canada
Status: Recruiting
Contact: Jennifer Rattenbury - 604-875-4111
Start Date
May 2005
Completion Date
December 2011
Sponsors
University of British Columbia
Source
University of British Columbia
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page