Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers
Conditions
Lung Cancer - Mesothelioma
Conditions: official terms
Lung Neoplasms - Mesothelioma
Conditions: Keywords
Lung Cancer, Mesothelioma, Asbestos, Screening, Early Diagnosis
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case Control
Overall Status
Recruiting
Summary
Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 85 Years
Minimum Age: 30 Years
Gender: Both
Criteria: Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)
Location
Princess Margaret Hospital
Toronto, Ontario, Canada
Status: Recruiting
Contact: Demetris Patsios, MD - Tel: (416) 603-5800 - demetris.patsios@uhn.on.ca
Start Date
March 2005
Completion Date
March 2017
Sponsors
University Health Network, Toronto
Source
University Health Network, Toronto
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page