Trial Title:
Tissue Bank of Biological Specimens From Patients With Gynecologic Disease
NCT ID:
NCT00299481
Condition:
Endometrial Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Leiomyoma
Conditions: Official terms:
Neoplasms
Ovarian Neoplasms
Leiomyoma
Myofibroma
Uterine Cervical Neoplasms
Endometrial Neoplasms
Conditions: Keywords:
Tissue Bank
Endometrial neoplasm
uterine cervical neoplasm
ovarian neoplasm
leiomyoma
DNA
RNA
Protein
Serum
Study type:
Observational
Overall status:
Unknown status
Study design:
Time perspective:
Prospective
Summary:
The purpose of this study is to create a tissue bank of gynecologic cancers and normal
tissue for the study of cancer in order to better understand the changes occurring on a
molecular level (DNA, RNA, protein) that lead to the development of cancer.
Detailed description:
Cancer arises due to genetic alterations that disrupt numerous cellular functions
including proliferation, programmed cell death and senescence, that ultimately control
the number of cells in a population. The genetic damage that underlies the development of
cancers has a diverse etiology and loss of DNA repair mechanisms also may play a role in
allowing mutations to accumulate. Cancers are also characterized by the ability to invade
surrounding tissues and to metastasize. Many of the molecular alterations involved in
this process have yet to be elucidated.
Gynecologic cancers afflict women of all ages. Cervical cancer is the most common
gynecologic malignancy worldwide, accounting for over 400,000 cases annually. Endometrial
cancer is the most common gynecologic malignancy with approximately 33,000 new cases
being diagnosed annually in American women. Ovarian cancer is the fourth most common
cause of cancer related mortality in American women, with approximately 14,000 deaths
occurring from it in 2000.
The creation of a tissue repository containing tissue specimens, blood/serum, and
molecular extracts (DNA, RNA, protein) will provide a rich source of tissue for future
gynecological disease research studies.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients scheduled to undergo surgery for diagnosis and treatment of a gynecologic
disease at one of the participating institutions
- > = 18 years old
- Ability to read English
Exclusion Criteria:
- < 18 years old
Gender:
Female
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Washington Hospital Center
Address:
City:
Washington
Zip:
20010
Country:
United States
Status:
Recruiting
Contact:
Last name:
Velega E Roberts, RN, MS
Phone:
202-877-8517
Email:
Velega.E.Roberts@medstar.net
Investigator:
Last name:
Jonathon Cosin, MD
Email:
Principal Investigator
Facility:
Name:
Gynecologic Disease Center, Walter Reed Army Medical Center
Address:
City:
Washington
Zip:
20307
Country:
United States
Status:
Recruiting
Contact:
Last name:
Cynthia A Perry, MS
Phone:
(202) 782-8461
Email:
Cynthia.Perry@amedd.army.mil
Contact backup:
Last name:
Karen Livornese, RNC, BSN, CCRC
Phone:
(202) 782-6244
Email:
Karen.Livornese@amedd.army.mil
Investigator:
Last name:
LTC G. Larry Maxwell, MD
Email:
Principal Investigator
Facility:
Name:
Wayne State University Kamanos Cancer Institute
Address:
City:
Detroit
Zip:
48201
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Alison Fried
Phone:
313-576-9446
Email:
afried@med.wayne.edu
Investigator:
Last name:
Robert T Morris, MD
Email:
Principal Investigator
Facility:
Name:
Duke University Medical Center
Address:
City:
Durham
Zip:
27710
Country:
United States
Status:
Recruiting
Contact:
Last name:
Barbara Walukas, RN
Phone:
919-684-6159
Email:
barbara.walukas@duke.edu
Investigator:
Last name:
Andrew Berchuck, MD
Email:
Principal Investigator
Facility:
Name:
The Ohio State University
Address:
City:
Columbus
Zip:
43210
Country:
United States
Status:
Recruiting
Contact:
Last name:
Michele Vaughan
Phone:
614-582-0280
Email:
vaughan-2@medctr.osu.edu
Investigator:
Last name:
Jeffrey Fowler, MD
Email:
Principal Investigator
Facility:
Name:
University of Pittsburgh Medical Center
Address:
City:
Pittsburgh
Zip:
15232
Country:
United States
Status:
Recruiting
Contact:
Last name:
Tracy Davis, RN
Phone:
412-641-1157
Email:
tdavis@mail.magee.edu
Investigator:
Last name:
Robert Edwards, MD
Email:
Principal Investigator
Facility:
Name:
Windber Research Institute
Address:
City:
Windber
Zip:
15963
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Micheal Liebman, PhD
Phone:
814-467-9844
Investigator:
Last name:
Micheal Liebman, PhD
Email:
Principal Investigator
Start date:
March 2006
Completion date:
January 2011
Lead sponsor:
Agency:
U.S. Army Medical Research and Development Command
Agency class:
U.S. Fed
Collaborator:
Agency:
Walter Reed Army Medical Center
Agency class:
U.S. Fed
Collaborator:
Agency:
Ohio State University
Agency class:
Other
Collaborator:
Agency:
University of Pittsburgh
Agency class:
Other
Collaborator:
Agency:
Duke University
Agency class:
Other
Collaborator:
Agency:
H. Lee Moffitt Cancer Center and Research Institute
Agency class:
Other
Collaborator:
Agency:
Windber Research Institute
Agency class:
Other
Collaborator:
Agency:
Medstar Health Research Institute
Agency class:
Other
Source:
Walter Reed Army Medical Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT00299481
