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Tissue Bank of Biological Specimens From Patients With Gynecologic Disease
Conditions
Endometrial Neoplasms - Uterine Cervical Neoplasms - Ovarian Neoplasms - Leiomyoma
Conditions: official terms
Endometrial Neoplasms - Leiomyoma - Neoplasms - Ovarian Neoplasms - Uterine Cervical Neoplasms
Conditions: Keywords
Tissue Bank, Endometrial neoplasm, uterine cervical neoplasm, ovarian neoplasm, leiomyoma, DNA, RNA, Protein, Serum
Study Type
Observational
Study Phase
N/A
Study Design
Time Perspective: Prospective
Overall Status
Recruiting
Summary
The purpose of this study is to create a tissue bank of gynecologic cancers and normal tissue for the study of cancer in order to better understand the changes occurring on a molecular level (DNA, RNA, protein) that lead to the development of cancer.
Detailed Description
Cancer arises due to genetic alterations that disrupt numerous cellular functions including proliferation, programmed cell death and senescence, that ultimately control the number of cells in a population. The genetic damage that underlies the development of cancers has a diverse etiology and loss of DNA repair mechanisms also may play a role in allowing mutations to accumulate. Cancers are also characterized by the ability to invade surrounding tissues and to metastasize. Many of the molecular alterations involved in this process have yet to be elucidated.
Gynecologic cancers afflict women of all ages. Cervical cancer is the most common gynecologic malignancy worldwide, accounting for over 400,000 cases annually. Endometrial cancer is the most common gynecologic malignancy with approximately 33,000 new cases being diagnosed annually in American women. Ovarian cancer is the fourth most common cause of cancer related mortality in American women, with approximately 14,000 deaths occurring from it in 2000.
The creation of a tissue repository containing tissue specimens, blood/serum, and molecular extracts (DNA, RNA, protein) will provide a rich source of tissue for future gynecological disease research studies.
Gynecologic cancers afflict women of all ages. Cervical cancer is the most common gynecologic malignancy worldwide, accounting for over 400,000 cases annually. Endometrial cancer is the most common gynecologic malignancy with approximately 33,000 new cases being diagnosed annually in American women. Ovarian cancer is the fourth most common cause of cancer related mortality in American women, with approximately 14,000 deaths occurring from it in 2000.
The creation of a tissue repository containing tissue specimens, blood/serum, and molecular extracts (DNA, RNA, protein) will provide a rich source of tissue for future gynecological disease research studies.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:
- Patients scheduled to undergo surgery for diagnosis and treatment of a gynecologic disease at one of the participating institutions
- > = 18 years old
- Ability to read English
Exclusion Criteria:
- < 18 years old
- Patients scheduled to undergo surgery for diagnosis and treatment of a gynecologic disease at one of the participating institutions
- > = 18 years old
- Ability to read English
Exclusion Criteria:
- < 18 years old
Locations
Gynecologic Disease Center, Walter Reed Army Medical Center
Washington, District of Columbia, United States
Washington Hospital Center
Status: Recruiting
Contact: Cynthia A Perry, MS - (202) 782-8461 - Cynthia.Perry@amedd.army.mil
Washington, District of Columbia, United States
Wayne State University Kamanos Cancer Institute
Status: Recruiting
Contact: Velega E Roberts, RN, MS - 202-877-8517 - Velega.E.Roberts@medstar.net
Detroit, Michigan, United States
Duke University Medical Center
Status: Not yet recruiting
Contact: Alison Fried - 313-576-9446 - afried@med.wayne.edu
Durham, North Carolina, United States
The Ohio State University
Status: Recruiting
Contact: Barbara Walukas, RN - 919-684-6159 - barbara.walukas@duke.edu
Columbus, Ohio, United States
University of Pittsburgh Medical Center
Status: Recruiting
Contact: Michele Vaughan - 614-582-0280 - vaughan-2@medctr.osu.edu
Pittsburgh, Pennsylvania, United States
Windber Research Institute
Status: Recruiting
Contact: Tracy Davis, RN - 412-641-1157 - tdavis@mail.magee.edu
Windber, Pennsylvania, United States
Status: Not yet recruiting
Contact: Micheal Liebman, PhD - 814-467-9844
Start Date
March 2006
Completion Date
January 2011
Sponsors
U.S. Army Medical Research and Materiel Command
Source
Walter Reed Army Medical Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
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