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The Effect of Ablation Therapy on Barrett's Esophagus
Conditions
Barrett's Esophagus - Early Esophageal Adenocarcinoma
Conditions: official terms
Adenocarcinoma - Barrett Esophagus - Esophageal Neoplasms
Conditions: Keywords
Photodynamic Therapy, Barrett's Esophagus, Early Esophageal Adenocarcinoma
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Intervention
Name: Biopsy
Type: Biological
Overall Status
Recruiting
Summary
To assess the effect of ablative therapy (Photodynamic Therapy or Radiofrequency ablation ) on Barrett's Esophagus
Detailed Description
To assess the effect of ablation therapy on Barrett's esophagus. Proposal Ablation therapy is an FDA approved treatment to decrease cancer risk in Barrett's esophagus mucosa. This is being performed in our Barrett's Esophagus Unit on a regular basis. However, the longterm outcomes of this therapy is not established and there are patients who have been treated who later re-develop Barrett's mucosa. This study will allow us store tissue samples that can later be used to assess the effect of ablative therapy on Barrett's esophagus.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 90 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:
- Patients who have had or qualify for ablation therapy for treatment of their barrett's esophagus with high grade dysplasia or early esophageal adenocarcinoma
- Ability to provide informed consent
Exclusion Criteria:
- Eastern Cooperative Oncology Group performance status 3 or 4
- Inability to tolerate endoscopic procedures
- Pregnancy: Females of child-bearing age will be screened with pregnancy test.
- Patients who have had or qualify for ablation therapy for treatment of their barrett's esophagus with high grade dysplasia or early esophageal adenocarcinoma
- Ability to provide informed consent
Exclusion Criteria:
- Eastern Cooperative Oncology Group performance status 3 or 4
- Inability to tolerate endoscopic procedures
- Pregnancy: Females of child-bearing age will be screened with pregnancy test.
Location
Mayo Clinic
Rochester, Minnesota, United States
Status: Recruiting
Contact: Lori S Lutzke - 507-255-7495 - lutzke.lori@mayo.edu
Start Date
January 2004
Completion Date
January 2022
Sponsors
Mayo Clinic
Source
Mayo Clinic
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page