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Trial Title: The Effect of Ablation Therapy on Barrett's Esophagus

NCT ID: NCT00587314

Condition: Barrett's Esophagus
Early Esophageal Adenocarcinoma

Conditions: Official terms:
Adenocarcinoma
Barrett Esophagus

Conditions: Keywords:
Photodynamic Therapy
Barrett's Esophagus
Early Esophageal Adenocarcinoma

Study type: Observational

Overall status: Enrolling by invitation

Study design:

Time perspective: Prospective

Intervention:

Intervention type: Other
Intervention name: Biopsy
Description: Biopsies for research purposes will be obtained when returning for clinically indicated surveillance of Barrett's Esophagus
Arm group label: 1

Summary: To assess the effect of ablative therapy (Photodynamic Therapy or Radiofrequency ablation ) on Barrett's Esophagus

Detailed description: To assess the effect of ablation therapy on Barrett's esophagus. Proposal Ablation therapy is an FDA approved treatment to decrease cancer risk in Barrett's esophagus mucosa. This is being performed in our Barrett's Esophagus Unit on a regular basis. However, the longterm outcomes of this therapy is not established and there are patients who have been treated who later re-develop Barrett's mucosa. This study will allow us store tissue samples that can later be used to assess the effect of ablative therapy on Barrett's esophagus.

Criteria for eligibility:

Study pop:
Patients who have had or qualify for ablation therapy for treatment of their barrett's esophagus

Sampling method: Non-Probability Sample
Criteria:
Inclusion Criteria: - Patients who have had or qualify for ablation therapy for treatment of their barrett's esophagus with high grade dysplasia or early esophageal adenocarcinoma - Ability to provide informed consent Exclusion Criteria: - Eastern Cooperative Oncology Group performance status 3 or 4 - Inability to tolerate endoscopic procedures - Pregnancy: Females of child-bearing age will be screened with pregnancy test.

Gender: All

Minimum age: 18 Years

Maximum age: 90 Years

Healthy volunteers: No

Locations:

Facility:
Name: Mayo Clinic

Address:
City: Rochester
Zip: 55905
Country: United States

Start date: January 2004

Completion date: January 2025

Lead sponsor:
Agency: Mayo Clinic
Agency class: Other

Source: Mayo Clinic

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT00587314

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