Allogeneic Whole Cell Cancer Vaccine for Metastatic Epithelial Tumors
Colorectal Cancer - Ovarian Cancer - Gastric Cancer - Breast Cancer - Lung Cancer
Study Type
Study Phase
Phase 1/Phase 2
Study Design
Name: Allogeneic whole epithelial tumor cells, DNP-conjugated and irradiated
Type: Biological
Overall Status
Not yet recruiting
This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with colorectal, gastric, ovarian, breast or lung epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals . This protocol is expected to prolong survival of metastatic epithelial cancer patients.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Metastatic epithelial cancer

- Above 18 years of age

- Failure of at least one chemotherapy protocol

- Clinical performance status of ECOG 0,1

- Absolute neutrophil count greater than 1000/mm3

- Serum ALT/AST less than three times the upper limit of normal

- Serum creatinine less than or equal to 1.6 mg/dl.

- Must be able to understand and sign the Informed Consent document

Exclusion Criteria:

- Below 18 years of age

- Women who are pregnant

- Life expectancy of less than three months
Hadassah Medical Organization
Jerusalem, Israel
Status: Not yet recruiting
Hadassah Medical Organization
Hadassah Medical Organization
Record processing date processed this data on July 28, 2015 page