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Trial Title:
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
NCT ID:
NCT00757614
Condition:
Bladder Cancer
Brain and Central Nervous System Tumors
Esophageal Cancer
Intraocular Melanoma
Kidney Cancer
Lymphoma
Melanoma (Skin)
Pancreatic Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter
Conditions: Official terms:
Lymphoma
Melanoma
Pancreatic Neoplasms
Urinary Bladder Neoplasms
Esophageal Neoplasms
Kidney Neoplasms
Nervous System Neoplasms
Central Nervous System Neoplasms
Carcinoma, Transitional Cell
Ureteral Neoplasms
Conditions: Keywords:
AIDS-related lymphoma
cutaneous lymphoma
adult Hodgkin lymphoma
adult non-Hodgkin lymphoma
intraocular lymphoma
adult T-cell leukemia/lymphoma
primary central nervous system non-Hodgkin lymphoma
primary central nervous system Hodgkin lymphoma
noncutaneous extranodal lymphoma
adult astrocytic tumors
adult brain stem glioma
adult choroid plexus tumor
adult craniopharyngioma
adult embryonal tumor
adult ependymal tumors
adult meningeal tumor
adult oligodendroglial tumors
adult pineal parenchymal tumor
adult brain tumor
intraocular melanoma
bladder cancer
clear cell sarcoma of the kidney
congenital mesoblastic nephroma
esophageal cancer
melanoma
pancreatic cancer
peripheral primitive neuroectodermal tumor of the kidney
renal cell carcinoma
rhabdoid tumor of the kidney
transitional cell cancer of the renal pelvis and ureter
Study type:
Observational
Overall status:
Unknown status
Intervention:
Intervention type:
Genetic
Intervention name:
DNA analysis
Intervention type:
Genetic
Intervention name:
polymorphism analysis
Intervention type:
Other
Intervention name:
laboratory biomarker analysis
Intervention type:
Other
Intervention name:
questionnaire administration
Summary:
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions
between genes and the environment in patients with cancer in East Anglia, Trent, or West
Midlands of the United Kingdom.
Detailed description:
OBJECTIVES:
- To obtain epidemiological information and biological material on a population-based
series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney,
esophageal, and pancreatic cancer, and brain tumors.
- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in
cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in
predisposition genes.
- To evaluate interactions between polymorphisms in predisposition genes and potential
lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire that includes information on
education, occupation, smoking habits, alcohol consumption, height, weight, reproductive
history (age at menarche, age at pregnancies, parity, and age at menopause), oral
contraceptive use, hormone replacement therapy use, family history of cancer, and past
medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples,
from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and
from additional controls through the European Prospective Investigation of Cancer (EPIC)
study (a population-based study of diet and health based in Norfolk, East Anglia). DNA
samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the cancer patients recruited for this study, patients with breast,
ovarian, endometrial, colorectal, and prostate cancer are recruited for the following
related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN,
MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.
Criteria for eligibility:
Criteria:
DISEASE CHARACTERISTICS:
- Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer,
brain cancer, malignant melanoma, or lymphoma within the past 5 years
- Identified through the Cancer Research Network OR through the cancer registry
serving any of the following geographic regions of the United Kingdom:
- East Anglia
- West Midlands
- Trent
PATIENT CHARACTERISTICS:
- Identified by the patient's general practitioner as fit to contact for this study
- No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
- Not specified
Gender:
All
Minimum age:
18 Years
Maximum age:
69 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
University of Cambridge Cancer Research UK
Address:
City:
Cambridge
Zip:
CB1 8RN
Country:
United Kingdom
Status:
Recruiting
Contact:
Last name:
Contact Person
Phone:
44-122-374-0166
Email:
paul.pharoah@srl.cam.ac.uk
Start date:
February 2008
Lead sponsor:
Agency:
Cancer Research UK
Agency class:
Other
Source:
National Cancer Institute (NCI)
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT00757614