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Trial Title: Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom

NCT ID: NCT00757614

Condition: Bladder Cancer
Brain and Central Nervous System Tumors
Esophageal Cancer
Intraocular Melanoma
Kidney Cancer
Lymphoma
Melanoma (Skin)
Pancreatic Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter

Conditions: Official terms:
Lymphoma
Melanoma
Pancreatic Neoplasms
Urinary Bladder Neoplasms
Esophageal Neoplasms
Kidney Neoplasms
Nervous System Neoplasms
Central Nervous System Neoplasms
Carcinoma, Transitional Cell
Ureteral Neoplasms

Conditions: Keywords:
AIDS-related lymphoma
cutaneous lymphoma
adult Hodgkin lymphoma
adult non-Hodgkin lymphoma
intraocular lymphoma
adult T-cell leukemia/lymphoma
primary central nervous system non-Hodgkin lymphoma
primary central nervous system Hodgkin lymphoma
noncutaneous extranodal lymphoma
adult astrocytic tumors
adult brain stem glioma
adult choroid plexus tumor
adult craniopharyngioma
adult embryonal tumor
adult ependymal tumors
adult meningeal tumor
adult oligodendroglial tumors
adult pineal parenchymal tumor
adult brain tumor
intraocular melanoma
bladder cancer
clear cell sarcoma of the kidney
congenital mesoblastic nephroma
esophageal cancer
melanoma
pancreatic cancer
peripheral primitive neuroectodermal tumor of the kidney
renal cell carcinoma
rhabdoid tumor of the kidney
transitional cell cancer of the renal pelvis and ureter

Study type: Observational

Overall status: Unknown status

Intervention:

Intervention type: Genetic
Intervention name: DNA analysis

Intervention type: Genetic
Intervention name: polymorphism analysis

Intervention type: Other
Intervention name: laboratory biomarker analysis

Intervention type: Other
Intervention name: questionnaire administration

Summary: RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer in East Anglia, Trent, or West Midlands of the United Kingdom.

Detailed description: OBJECTIVES: - To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors. - Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series. - To estimate the age and sex-specific risks associated with variants in predisposition genes. - To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors. OUTLINE: This is a multicenter study. Patients complete a detailed epidemiological questionnaire that includes information on education, occupation, smoking habits, alcohol consumption, height, weight, reproductive history (age at menarche, age at pregnancies, parity, and age at menopause), oral contraceptive use, hormone replacement therapy use, family history of cancer, and past medical history. Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes. In addition to the cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, and prostate cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.

Criteria for eligibility:
Criteria:
DISEASE CHARACTERISTICS: - Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer, brain cancer, malignant melanoma, or lymphoma within the past 5 years - Identified through the Cancer Research Network OR through the cancer registry serving any of the following geographic regions of the United Kingdom: - East Anglia - West Midlands - Trent PATIENT CHARACTERISTICS: - Identified by the patient's general practitioner as fit to contact for this study - No serious mental illness or retardation PRIOR CONCURRENT THERAPY: - Not specified

Gender: All

Minimum age: 18 Years

Maximum age: 69 Years

Healthy volunteers: No

Locations:

Facility:
Name: University of Cambridge Cancer Research UK

Address:
City: Cambridge
Zip: CB1 8RN
Country: United Kingdom

Status: Recruiting

Contact:
Last name: Contact Person

Phone: 44-122-374-0166
Email: paul.pharoah@srl.cam.ac.uk

Start date: February 2008

Lead sponsor:
Agency: Cancer Research UK
Agency class: Other

Source: National Cancer Institute (NCI)

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT00757614

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