Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma
Conditions
Carcinoma, Hepatocellular - Alcoholic Cirrhosis - Viral Cirrhosis - Postoperative Hepatic Failure
Conditions: official terms
Carcinoma - Carcinoma, Hepatocellular - Liver Cirrhosis - Liver Cirrhosis, Alcoholic - Liver Failure
Conditions: Keywords
Hepatic functional reserve, Hepatocellular carcinoma (HCC), Indocyanine Green retention rate at 15 minutes (ICG-R15'), Portal Pressure (PP), Hepatic Portal Venous Gradient (HPVG), Alcoholic and Viral Cirrhosis, Makuuchi criteria, Barcelona Clinic of Liver Cancer (BCLC), Hepatic resection
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
Recruiting
Summary
The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and non-alcoholic aetiologies. Alcoholic and viral cirrhosis present important differences in terms of cellular mechanisms responsible for the disease progression with a distinct and unique gene expression pattern that regulates the type of inflammatory response. These differences probably influence the hepatic functional reserve and the onset of portal hypertension at a comparable clinical and biological level of derangement and the investigators may expect significant differences in the recovery from hepatectomy.

The investigators' hypothesis is that at a comparable ICGR-15 rate non-viral cirrhotic liver presents higher portal pressure values and the investigators also argue that alcoholic cirrhotic patients would tolerate a larger hepatic resection than would viral cirrhotic do.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- resectable or amenable to resection HCC in cirrhotic child A patients of alcoholic or viral etiology

Exclusion Criteria:

- cirrhosis Child-Pugh B

- absence of patient consent

- psychiatric pathology
Location
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Vaud, Switzerland
Status: Recruiting
Contact: Diana Michele, MD - +41213142369 - michelediana@virgilio.it
Start Date
February 2009
Completion Date
December 2014
Sponsors
University of Lausanne Hospitals
Source
University of Lausanne Hospitals
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page