Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma
Carcinoma, Hepatocellular - Alcoholic Cirrhosis - Viral Cirrhosis - Postoperative Hepatic Failure
Conditions: official terms
Carcinoma - Carcinoma, Hepatocellular - Liver Cirrhosis - Liver Cirrhosis, Alcoholic - Liver Failure
Conditions: Keywords
Hepatic functional reserve, Hepatocellular carcinoma (HCC), Indocyanine Green retention rate at 15 minutes (ICG-R15'), Portal Pressure (PP), Hepatic Portal Venous Gradient (HPVG), Alcoholic and Viral Cirrhosis, Makuuchi criteria, Barcelona Clinic of Liver Cancer (BCLC), Hepatic resection
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and non-alcoholic aetiologies. Alcoholic and viral cirrhosis present important differences in terms of cellular mechanisms responsible for the disease progression with a distinct and unique gene expression pattern that regulates the type of inflammatory response. These differences probably influence the hepatic functional reserve and the onset of portal hypertension at a comparable clinical and biological level of derangement and the investigators may expect significant differences in the recovery from hepatectomy.

The investigators' hypothesis is that at a comparable ICGR-15 rate non-viral cirrhotic liver presents higher portal pressure values and the investigators also argue that alcoholic cirrhotic patients would tolerate a larger hepatic resection than would viral cirrhotic do.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- resectable or amenable to resection HCC in cirrhotic child A patients of alcoholic or viral etiology

Exclusion Criteria:

- cirrhosis Child-Pugh B

- absence of patient consent

- psychiatric pathology
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Vaud, Switzerland
Status: Recruiting
Contact: Diana Michele, MD - +41213142369 -
Start Date
February 2009
Completion Date
December 2014
University of Lausanne Hospitals
University of Lausanne Hospitals
Record processing date processed this data on July 28, 2015 page