Functional Imaging in HNC Undergoing Chemoradiation
Conditions
Head and Neck Cancer
Conditions: official terms
Head and Neck Neoplasms
Conditions: Keywords
head and neck cancer, DW MRI, PET, DCE MRI, functional imaging, IMRT
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
The purpose of the study is to generate a library of functional imaging and anatomical imaging for patients with head and neck cancers for evaluation of new radiotherapy strategies and planning techniques including IMRT. Secondary aims would be to observe the changes in the cancers as the treatment progresses as well as to define the biologically most active part of the tumor (biological target volume) which could be given more intensive treatment. Tumor volumes seen on different imaging modalities will be compared with a hope of finding an optimal imaging methodology for accurate visualization of the head and neck cancers
Detailed Description
Adult patients who have a head and neck cancer and are planned to receive chemotherapy and radiotherapy will be invited to participate in the study. Patients who are not in very good health, have diabetes or kidney failure will not be considered for the study. Also patients who can not undergo MRI scan or are allergic to contrast injection given prior to the scan or have had any other form of cancer (except skin cancer) will also be excluded from the study.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- patients with histologically proven head and neck cancer, planed for chemotherapy and radiotherapy

- age more than 18 years

- patient willing to participate and has signed a consent form

- patients in good physical status (WHO performance status 0-2)

Exclusion Criteria:

- patients in poor health (WHO performance status >2)

- patients with any other cancer apart from skin cancer

- patients with contraindications to MRI scan and IV contrast

- diabetic patients

- patients with renal failure
Location
The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom
Status: Recruiting
Contact: Kate Newbold - 02086613638 - kate.newbold@rmh.nhs.uk
Start Date
February 2009
Completion Date
November 2010
Sponsors
Royal Marsden NHS Foundation Trust
Source
Royal Marsden NHS Foundation Trust
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page