Biological Factors Predicting Response to Chemotherapy in Advanced Non Small Cell Lung Cancer
Non Small Cell Lung Carcinoma
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
Non small cell lung carcinoma, Chemotherapy, Response prediction
Study Type
Study Phase
Study Design
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Name: Chemotherapy
Type: Drug
Overall Status
The primary aim of the study is to identify a predictive molecular signature for response to chemotherapy, according to WHO criteria, in patients with non-small cell lung cancer by studying the transcriptome (miRNAs and mRNAs) and the single nucleotide polymorphism (SNPs) by using high throughput techniques.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histological diagnosis of non-small-cell lung cancer (NSCLC)

- Obtention of a biopsy of the tumour according to the procedure defined in the protocol

- NSCLC of any stage to be treated by standard conventional first-line chemotherapy, as defined in the ELCWP guidelines (

- Presence of at least one assessable lesion

- Availability for participating in the detailed follow-up of the protocol

- Signed informed consent.

- Age above 18 years

Exclusion Criteria:

- Patient who was previously treated with chemotherapy for NSCLC or who has any contra-indication precluding the administration of conventional chemotherapy for NSCLC

- NSCLC treated by exclusive surgery or radiotherapy

- A history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or of the bladder or cured malignant tumour (more than 5-year disease free interval)
Department of Pneumology Clinique Saint-Luc
Bouge, Belgium
Status: Recruiting
Contact: Oswald Van Cutsem, MD
Department of Intensive Care Unit and Thoracic Oncology Institut Jules Bordet
Brussels, Belgium
Status: Recruiting
Contact: Thierry Berghmans, MD - 0032/2/5390496
Service de Pneumologie Hôpital Erasme
Brussels, Belgium
Status: Recruiting
Contact: Paul deVuyst, MD, PhD
Department of Pneumology Hôpital Saint-Joseph
Gilly, Belgium
Status: Recruiting
Contact: Benoît Colinet, MD
Hôpital Ambroise Paré
Mons, Belgium
Status: Recruiting
Contact: Stéphane Holbrechts, MD
Department of Pneumology Centre Hospitalier de Mouscron
Mouscron, Belgium
Status: Recruiting
Contact: Christian Tulippe, MD
Start Date
March 2009
Completion Date
March 2021
European Lung Cancer Working Party
European Lung Cancer Working Party
Record processing date processed this data on July 28, 2015 page