Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
Brain Cancer - Glioma
Conditions: official terms
Conditions: Keywords
brain tumor, radiation, MRI, 09-009
Study Type
Study Phase
Study Design
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
Name: MRI and advanced MRI sequences
Type: Procedure
Overall Status
The purpose of this study is to assess the ability of these advanced MRI scans in predicting areas within a malignant glioma (brain tumor) that are at a high risk of recurring. If these advanced MRI scans are able to identify the cancerous part of the tumor, then radiation therapy can be targeted to those sites and possibly improve patient survival.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation

- May undergo radiation therapy

- Patient and/or guardian is able to provide written informed consent prior to study registration

- Age > or = to 18 years old

Exclusion Criteria:

- Claustrophobia

- Known allergic reaction to Gd-DTPA

- Renal insufficiency with recent (<3 month old) creatinine >2.0

- Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).

- Pregnant or nursing female

- Unable to cooperate for MRI and/or radiation therapy planning
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Status: Recruiting
Contact: Robert Young, MD
Start Date
March 2009
Completion Date
March 2016
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Record processing date processed this data on July 28, 2015 page