Gene Expression Profiles to Categorize Wilms Tumors
Conditions
Recurrent Wilms Tumor and Other Childhood Kidney Tumors - Stage I Wilms Tumor - Stage II Wilms Tumor - Stage III Wilms Tumor - Stage IV Wilms Tumor - Stage V Wilms Tumor
Conditions: official terms
Kidney Neoplasms - Neoplasms - Wilms Tumor
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Retrospective
Intervention
Name: laboratory biomarker analysis
Type: Other
Overall Status
Recruiting
Summary
This laboratory study is using gene expression profiling to identify different categories of Wilms tumors. Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
Detailed Description
OBJECTIVES:

I. Identify new molecular categories of Wilms tumor (WT) based on the gene expression profiles of samples from patients with this disease.

II. Develop a classifying system (classifier) that will predict a defined number of clinically relevant categories based on expression of an established set of genes.

III. Confirm and test the classifier with further analysis of the genes by several different methodologies, using additional patient samples that are outside of the case/cohort but which possess the clinically or scientifically relevant parameter.

IV. Validate the use of the classifier to predict defined groups within a second set of samples (for which investigators are blinded to the clinical and biological data) by subsequent comparison with true incidence of pertinent markers.

OUTLINE:

Three hundred tumor specimens are analyzed for genetic expression profiles using Affymetrix assays. Specific genes are identified as classifiers and analyzed using tissue arrays. An additional 300 specimens are examined for gene expression and categorized according to the classifiers.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- Specimens from patients previously enrolled as "On Study" or "Followed Biology Only" on protocol NWTSG-5 (COG-Q9401)

- Study follow-up data for disease status available

- National Wilms Tumor Study Group/Children's Oncology Group pathology review showing "favorable" histology

- Sufficient biology samples available without using biology bank reserves
Locations
Children's Oncology Group
Arcadia, California, United States
Status: Recruiting
Contact: Elizabeth J. Perlman, MD - 773-880-4306 - eperlman@childrensmemorial.org
Saint Mary's Hospital
West Palm Beach, Florida, United States
Status: Recruiting
Contact: Narayana Gowda, MD - 561-844-6363
Start Date
February 2004
Sponsors
Children's Oncology Group
Source
Children's Oncology Group
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page