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Influence of Thyroid Hormones on the Woundhealing Process
Conditions
Thyroid Neoplasms - Thyroid Carcinoma
Conditions: official terms
Thyroid Diseases - Thyroid Neoplasms
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Masking: Open Label, Primary Purpose: Basic Science
Intervention
Name: blood sampling
Type: Procedure
Name: blood sampling
Type: Procedure
Overall Status
Recruiting
Summary
Main goal of this clinical investigation is to investigate different cytokines in wound fluids of euthyroid vs. hypothyroid patients. As a primary endpoint we want to evaluate if different cytokine levels in euthyroid vs. hypothyroid patients exist and to what extent these cytokines differ. Our targeted cytokines are: IL6, IL10, TNFa and MCP-1. From the literature these 4 factors seem to be the most reasonable to measure and to focus on. Additionally we focus on these 4 factors for financial reasons, technically there wouldn't be a problem to measure more, which is correlated with higher costs. Besides, more than 6 factors would mean larger amounts of sample fluids needed, which would cause technical problems. These factors don`t have to change in the same direction. Secondarily, we believe that differences in cytokine profiles of hypothyroidism vs. euthyroidism will correlate to differences in duration and clinical characteristics of the wound healing process.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:
- Near total or total thyroidectomy because of struma multinodsa (nodular goiter) with or without substitution of thyroid hormone after operation
- Total thyroidectomy because of papillary carcinoma of thyroid gland (T1/T2 carcinoma, N1, M0) with planned radio-ablative therapy (RAT) without or with rhTSH
Exclusion Criteria:
- Pat< 18 years
- Immune disease of thyroid gland (Graves disease)
- Severe immunodeficiency
- Immunosuppressive medication because of solid Organ transplantation
- Hepatitis A/B/C or HIV
- All exclusion criteria for any surgical procedure
- Near total or total thyroidectomy because of struma multinodsa (nodular goiter) with or without substitution of thyroid hormone after operation
- Total thyroidectomy because of papillary carcinoma of thyroid gland (T1/T2 carcinoma, N1, M0) with planned radio-ablative therapy (RAT) without or with rhTSH
Exclusion Criteria:
- Pat< 18 years
- Immune disease of thyroid gland (Graves disease)
- Severe immunodeficiency
- Immunosuppressive medication because of solid Organ transplantation
- Hepatitis A/B/C or HIV
- All exclusion criteria for any surgical procedure
Location
Medizinische Hoochschule Hannover, Allgemein-, Viszeral-und Transplantationscirurgie OE 6220
Hannover, Germany
Status: Recruiting
Contact: Stephan Kaaden, Dr
Start Date
June 2009
Completion Date
April 2010
Sponsors
Hannover Medical School
Source
Hannover Medical School
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
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