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Trial Title: Leukemia Cell Cultures for Research of New Anti-Cancer Therapies

NCT ID: NCT00993538

Condition: Acute Leukaemia

Conditions: Official terms:
Leukemia

Conditions: Keywords:
Leukaemia
Blood and marrow cells culture
Cell growth
Cell differentiation

Study type: Interventional

Study phase: N/A

Overall status: Unknown status

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Basic Science

Masking: None (Open Label)

Intervention:

Intervention type: Procedure
Intervention name: Blood sampling
Arm group label: 1

Intervention type: Procedure
Intervention name: Bone marrow aspiration
Arm group label: 1

Summary: The main objective of this project is not only a better understanding of the human leukemic disease but also to find new anti-leukemic or improve existing ones. This study has, the following aims: - To analyze the genetic and epigenetic regulation of the retinoic acid induced cascade which leads to the expression of TRAIL in blood cells of patients with acute leukemia. This study will be complemented by the analysis of global gene expression (DNA chips) and of the DNA methylation state, and by chromatin immunoprecipitation experiences. - To determine the efficiency of inhibitors of enzymes responsible for the modification of chromatin (existing and new developments within the European consortium EPITRON coordinated by Dr Gronemeyer) as inducers of differentiation and / or apoptosis of leukemic blasts. - To explore Ikaros genic and functional abnormalities (genomic deletions, mutations, abnormal transcripts and proteins) in acute leukemia. The aim is to determine if these abnormalities may play a prognosis role.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Patients with suspected de novo or secondary or relapsed acute leukemia, requiring complementary blood test and bone marrow analysis - Patients older or equal than 28 days - Informed consent signed Exclusion Criteria: - Pregnancy - Breastfeeding

Gender: All

Minimum age: 28 Days

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Service d'Hématologie et d'Oncologie

Address:
City: Strasbourg
Zip: 67098
Country: France

Status: Recruiting

Contact:
Last name: Raoul Herbrecht, MD

Phone: 3.33.88.12.83.79
Email: Raoul.herbrecht@chru-strasbourg.fr

Investigator:
Last name: Raoul Herbrecht, MD
Email: Principal Investigator

Investigator:
Last name: Cécile Fohrer, MD
Email: Sub-Investigator

Investigator:
Last name: Luc Fornecker, MD
Email: Sub-Investigator

Investigator:
Last name: Bruno Lioure, MD
Email: Sub-Investigator

Investigator:
Last name: Karin Bilger, MD
Email: Sub-Investigator

Facility:
Name: Service de Pédiaterie - Hôpital de Hautepierre

Address:
City: Strasbourg
Zip: 67098
Country: France

Status: Recruiting

Contact:
Last name: Patrick Lutz, MD

Phone: 3.33.88.12.80.90
Email: Patrick.lutz@chru-strasbourg.fr

Investigator:
Last name: Patrick Lutz, MD
Email: Principal Investigator

Investigator:
Last name: Natacha Entz-Werle, MD
Email: Sub-Investigator

Start date: July 2009

Lead sponsor:
Agency: University Hospital, Strasbourg, France
Agency class: Other

Source: University Hospital, Strasbourg, France

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT00993538

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