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Trial Title:
Leukemia Cell Cultures for Research of New Anti-Cancer Therapies
NCT ID:
NCT00993538
Condition:
Acute Leukaemia
Conditions: Official terms:
Leukemia
Conditions: Keywords:
Leukaemia
Blood and marrow cells culture
Cell growth
Cell differentiation
Study type:
Interventional
Study phase:
N/A
Overall status:
Unknown status
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Basic Science
Masking:
None (Open Label)
Intervention:
Intervention type:
Procedure
Intervention name:
Blood sampling
Arm group label:
1
Intervention type:
Procedure
Intervention name:
Bone marrow aspiration
Arm group label:
1
Summary:
The main objective of this project is not only a better understanding of the human
leukemic disease but also to find new anti-leukemic or improve existing ones. This study
has, the following aims:
- To analyze the genetic and epigenetic regulation of the retinoic acid induced
cascade which leads to the expression of TRAIL in blood cells of patients with acute
leukemia. This study will be complemented by the analysis of global gene expression
(DNA chips) and of the DNA methylation state, and by chromatin immunoprecipitation
experiences.
- To determine the efficiency of inhibitors of enzymes responsible for the
modification of chromatin (existing and new developments within the European
consortium EPITRON coordinated by Dr Gronemeyer) as inducers of differentiation and
/ or apoptosis of leukemic blasts.
- To explore Ikaros genic and functional abnormalities (genomic deletions, mutations,
abnormal transcripts and proteins) in acute leukemia. The aim is to determine if
these abnormalities may play a prognosis role.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients with suspected de novo or secondary or relapsed acute leukemia, requiring
complementary blood test and bone marrow analysis
- Patients older or equal than 28 days
- Informed consent signed
Exclusion Criteria:
- Pregnancy
- Breastfeeding
Gender:
All
Minimum age:
28 Days
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Service d'Hématologie et d'Oncologie
Address:
City:
Strasbourg
Zip:
67098
Country:
France
Status:
Recruiting
Contact:
Last name:
Raoul Herbrecht, MD
Phone:
3.33.88.12.83.79
Email:
Raoul.herbrecht@chru-strasbourg.fr
Investigator:
Last name:
Raoul Herbrecht, MD
Email:
Principal Investigator
Investigator:
Last name:
Cécile Fohrer, MD
Email:
Sub-Investigator
Investigator:
Last name:
Luc Fornecker, MD
Email:
Sub-Investigator
Investigator:
Last name:
Bruno Lioure, MD
Email:
Sub-Investigator
Investigator:
Last name:
Karin Bilger, MD
Email:
Sub-Investigator
Facility:
Name:
Service de Pédiaterie - Hôpital de Hautepierre
Address:
City:
Strasbourg
Zip:
67098
Country:
France
Status:
Recruiting
Contact:
Last name:
Patrick Lutz, MD
Phone:
3.33.88.12.80.90
Email:
Patrick.lutz@chru-strasbourg.fr
Investigator:
Last name:
Patrick Lutz, MD
Email:
Principal Investigator
Investigator:
Last name:
Natacha Entz-Werle, MD
Email:
Sub-Investigator
Start date:
July 2009
Lead sponsor:
Agency:
University Hospital, Strasbourg, France
Agency class:
Other
Source:
University Hospital, Strasbourg, France
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT00993538
