How Our Immune System Can Help Fight Cancer
Ovarian Cancer
Conditions: official terms
Ovarian Neoplasms
Conditions: Keywords
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
Not yet recruiting
There is growing evidence that our immune system can help fight cancer. This has stimulated interest in the development and application of tumor vaccines for several human solid tumors, including epithelial ovarian cancer (EOC). A major obstacle to the development of these vaccines is that there are specialty cells called regulatory T cells that prevent the immune system from attacking all of our organs. These regulatory T cells also prevent our immune system for attacking cancer cells.

Indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades an essential amino acid tryptophan that is necessary for T cells to multiply, however regulatory T cells are less susceptible to low levels of tryptophan, and can still multiply. This allows cancer growth and progression. This may be explained by genetic polymorphisms (changes) in the IDO gene, which may alter its function. Five of these changes in the IDO gene have been described. In this research project, we are asking if you would donate a small piece of your tumor and ascites to see if we can examine your IDO gene in the tumor cells and see if any of these gene changes are present. We hope that this will help us understand how the immune system works in EOC.

We hypothesize that genetic polymorphisms within the IDO gene alter its enzymatic activity and affect the outcome of ovarian cancer patients. These findings have the potential to translate into a method for predicting successful immunotherapy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 90 Years
Minimum Age: 20 Years
Gender: Female
Criteria: Inclusion Criteria:

- females aged 20-90 who are having surgery to confirm epithelial ovarian cancer.

Exclusion Criteria:

- patients who have a diagnosis of non-epithelial histology.
Winthrop-University Hospital
Mineola, New York, United States
Status: Not yet recruiting
Contact: Jeanne Villella, DO - 516-663-2018 -
Start Date
January 2010
Completion Date
January 2011
Winthrop University Hospital
Winthrop University Hospital
Record processing date processed this data on July 28, 2015 page