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Trial Title:
Development of a Diagnostic Kit for FLT3-ITD in Acute Myeloid Leukemia
NCT ID:
NCT01141673
Condition:
Acute Myeloid Leukemia
Conditions: Official terms:
Leukemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Conditions: Keywords:
FLT3-ITD
acute myeloid leukemia
FLT3
D835
Study type:
Observational
Overall status:
Unknown status
Study design:
Time perspective:
Prospective
Summary:
FLT3 overexpression in acute myeloid leukemia (AML) is often caused by mutations in this
gene. These mutations cause constitutive phosphorylation of FLT3 proteins leading to
increased proliferation and survival, decreased apoptosis and resistance to
chemotherapeutic agents in AML cells. There are two major types of FLT3 mutations-
internal tandem duplication (ITD) and point mutation at 835th amino residue. AMLs with
FLT3 mutations have worse prognosis and are often resistant to conventional chemotherapy.
Several small molecule compounds targeting FLT3 have been in the market or in clinical
trials. Therefore, identification of these mutations at the time of diagnosis will
provide a better prognostic prediction, might guide the treatment selection and follow-up
strategies. In this study, the investigators will develop a sensitive molecular assay to
detect FLT3 mutations for future clinical application. The investigators will collect 100
AML samples with at least 20 samples with known FLT3 mutations. The investigators will
compare this assay with commonly used methods and standardize the procedure to meet the
requirement of clinical pathology laboratory with reasonable cost.
Criteria for eligibility:
Study pop:
acute myeloid leukemia patient in wanfang hospital
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Patients with confirmed diagnosis of acute myeloid leukemia
Exclusion Criteria:
- non
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Taipei Medical University - WanFang Hospital
Address:
City:
Taipei
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Hsin-Gjin Eugene Liu
Phone:
886-2-29307930
Phone ext:
2548
Email:
liuxx086@gmail.com
Start date:
June 2010
Completion date:
June 2011
Lead sponsor:
Agency:
Taipei Medical University WanFang Hospital
Agency class:
Other
Source:
Taipei Medical University WanFang Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT01141673
