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Trial Title:
Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma
NCT ID:
NCT01330342
Condition:
HIV
Lymphoma
Conditions: Official terms:
Lymphoma
Study type:
Observational
Overall status:
Unknown status
Study design:
Summary:
The study's chief objective is to observe the evolution of cellular (in terms of
expression of transmembrane transporters and their transcriptional regulators) and viral
resistance (in terms of development of mutations in the HIV genome that may confer
resistance to future treatment for HIV) in HIV-infected patients with lymphoma.
Detailed description:
The study team will take two or three tubes of blood on three occasions during the course
of chemotherapy. The total amount of blood required for this research project is 64mL
(approximately 4 tablespoons).
This will allow better understanding of the changes that take place in the blood and the
HIV virus itself. It is hoped that this will provide new insights that may aid the
understanding and treatment of HIV patients with lymphoma.
Criteria for eligibility:
Study pop:
HIV seropositive individuals with and without lymphoma.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- The ability to understand and sign a written informed consent form, prior to
participation in any screening procedure and must be willing to comply with all
study requirements.
- Documented HIV-1 infection.
- Diagnosis of lymphoma (with the exclusion of the five subjects that will be
controls).
- On cART or about to start cART as part of clinical routine care before the
initiation of chemotherapy.
Exclusion Criteria:
- Receiving anti-tuberculosis treatment.
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
St Stephen's Centre
Address:
City:
London
Zip:
SW10 9NH
Country:
United Kingdom
Status:
Recruiting
Contact:
Last name:
Marta Boffito, Dr
Email:
marta.boffito@chelwest.nhs.uk
Investigator:
Last name:
Marta Boffito, Dr
Email:
Principal Investigator
Start date:
May 2011
Completion date:
May 2014
Lead sponsor:
Agency:
St Stephens Aids Trust
Agency class:
Other
Source:
St Stephens Aids Trust
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT01330342
