Decreasing Postoperative Complications by Goal-Directed Fluid Therapy During Esophageal Resection
Conditions
Esophageal Cancer
Conditions: official terms
Esophageal Neoplasms - Postoperative Complications
Conditions: Keywords
fluid, goal-directed, FloTrac, pulse contour analysis, postoperative complications, anesthesia, esophagus
Study Type
Interventional
Study Phase
Phase 4
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Intervention
Name: fluid optimisation
Type: Other
Overall Status
Recruiting
Summary
Surgery for cancer of the esophagus is associated with a high risk of postoperative complications. It has been shown that the risk of postoperative complications can be decreased by optimising the amount and type of infusion fluids given during surgery, steered by measurement of cardiac stroke volume, mostly done with a device called esophageal Doppler. This device can however not be used during this type of surgery. This study wants to test the hypothesis that postoperative complications in patients operated for esophageal cancer can be partially prevented by using a goal directed strategy for the administration of fluids and drugs influencing the heart and vessels, based on measurement of stroke volume by pulse wave analysis (FloTrac).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Patients scheduled for transthoracic esophageal resection because of malignancy, without colonic interposition who leave informed consent

Exclusion Criteria:

- ASA 4 or 5

- Atrial Fibrillation

- Significant Aortic or Mitral Valve Insufficiency

- Preoperative planned extensive monitoring beyond CVP, arterial blood pressure, diuresis, ECG and other standard monitors
Location
University Hospital Linkoeping
Linkoeping, Sweden
Status: Recruiting
Contact: Lena Nilsson - +46-10-1031838 - lena.nilsson@ds.se
Start Date
October 2011
Completion Date
September 2015
Sponsors
University Hospital, Linkoeping
Source
University Hospital, Linkoeping
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page