Short-course Preoperative Chemoradiotherapy for Rectal Cancer
Rectal Cancer
Conditions: official terms
Rectal Neoplasms
Conditions: Keywords
Locally advanced rectal cancer
Study Type
Study Phase
Phase 2
Study Design
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Name: short-course radiation
Type: Radiation
Overall Status
The purpose of this study is to evaluate the early clinical outcome of the short-course preoperative chemoradiotherapy, 33Gy/10 fx and delayed operation after chemoradiation, the investigators initiated the clinical trial of KROG 11-02.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

1. histologically confirmed adenocarcinoma

2. distal margin of the tumor located < 8 cm above the anal verge

3. cT3-4 or cN+ classification as determined by endorectal ultrasonography (EUS) and CT

4. patient older than age 18 years

5. Karnofsky performance score >= 70

Exclusion Criteria:

1. distant metastasis identified during staging workup

2. previous or concurrent malignancy

3. pregnant or breast-feeding women

4. impending rectal obstruction

5. familial adenomatous polyposis
National Cancer Center, Korea
Goyang, Korea, Republic of
Status: Recruiting
Contact: Dae Yong Kim, MD -
Samsung Medical Center
Seoul, Korea, Republic of
Status: Recruiting
Contact: Hee Chul Park, MD -
Seoul National University Hospital
Seoul, Korea, Republic of
Status: Recruiting
Contact: Eui Kyu Chie, MD -
Start Date
September 2011
Completion Date
October 2017
Seoul St. Mary's Hospital
Seoul St. Mary's Hospital
Record processing date processed this data on July 28, 2015 page