Prevention of Post-operative Pneumonia (POPP)
Conditions
Post-operative Pneumonia - Lung Cancer - Esophageal Cancer
Conditions: official terms
Esophageal Neoplasms - Pneumonia
Conditions: Keywords
Incidence of post-operative pneumonia in patients undergoing surgery for primary lung cancer or primary esophageal cancer
Study Type
Interventional
Study Phase
Phase 2/Phase 3
Study Design
Allocation: Randomized, Masking: Open Label, Primary Purpose: Prevention
Intervention
Name: Intensive Brushing Regimen
Type: Procedure
Overall Status
Recruiting
Summary
Postoperative pneumonia is a major complication in patients undergoing thoracic surgery. It leads to considerable morbidity and contributes to perioperative morbidity. There is evidence in literature that supports the use of strategies for improved oral hygiene and specialized endotracheal tubes in preventing ventilator associated pneumonia (VAP) in mechanically ventilated patients. This study aims at utilizing a combination of these interventions in the perioperative period in patients undergoing planned thoracic surgical procedures.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

1. Patients with lung lesions undergoing anatomic resection (lobectomy/segmentectomy/bilobectomy/pulmonary sleeve resection/pneumonectomy)

2. Patients with poor lung function (FEV1% <50% or DLCO<50% predicted or home oxygen requirement) and lung lesions undergoing non-anatomic lung resection (i.e. wedge resection).

3. Patients undergoing esophageal resection.

Exclusion Criteria:

1. Patients with ongoing symptomatic dental infections.

2. Patients with recent/ongoing pneumonia (<15 days from initial surgical patient evaluation).

3. Patients who've received a therapeutic course of antibiotics within 15 days prior to thoracic surgery.

4. Patients with a preexisting tracheostomy.

5. Age<18
Location
Washington University School of Medicine
St. Louis, Missouri, United States
Status: Recruiting
Contact: Jennifer M Bell, RN, BSN - 314-747-6969 - bellj@wudosis.wustl.edu
Start Date
September 2011
Sponsors
Washington University School of Medicine
Source
Washington University School of Medicine
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page