Epidemiology of Uterine Cancer in Taiwan

Trial Title: Epidemiology of Uterine Cancer in Taiwan

NCT ID: NCT01465737

Condition: Uterine Cancers

Conditions: Official terms:
Uterine Neoplasms

Conditions: Keywords:
epidemiology
uterine cancer
Taiwan

Study type: Observational

Overall status: Unknown status

Study design:

Time perspective: Retrospective

Intervention:

Intervention type: Other
Intervention name: Histologic types
Description: evaluate survival among different histologic types
Arm group label: Patients with uterine cancer

Summary: Endometrial cancer is the second most common gynecologic cancer in Taiwan. Two types of endometrial cancer may be distinguished by standard clinicopathologic criteria; type I tumors are of low grade, endometrioid histology, estrogen related, and have a good prognosis, whereas type II tumors are high grade, of non-endometrioid histologies, unrelated to estrogen, and have a poor prognosis. Several clinicopathological parameters were reported to correlate with prognosis of endometrial cancer including tumor FIGO stage, cell type, cytological grading, depth of myometrial invasion, tumor size, lymph node status, and etc. However, there is no epidemiologic data of endometrial cancer in Taiwan. So the investigators propose this study to use Taiwan registry database provided by Department of Health to analyze the epidemiology and prognosis of uterine cancer patients in Taiwan.

Detailed description: Study population To evaluate the epidemiology and prognosis of uterine cancer in Taiwan, we will conduct a nationwide analysis through linking national cancer registry database. Every citizen in Taiwan has a life-long identification number to link individual information, including health status. The Taiwan household registry database provided by Department of Health will be the source population. National household registry and death certificate will be adopted to ascertain the live status of study subjects, and provided individual demographic characteristics. All individual linkages between databases will be conducted according to the study protocols, i.e. databases will be linked by corresponding identification number, name (Chinese characters) and birthday, and all data included in this study will be analyzed without individual identification information. The agreement of utilizing the databases in the study was obtained from the Bureau of Health Promotion in Taiwan. Incident and death cases ascertainment Patients with uterine cancer, including uterine carcinoma, uterine sarcoma ... etc., will be identified from computerized linkage to the Taiwan national cancer registry with International Classification of Diseases for Oncology Third Edition T-code C540-C543. Histological types will be identified from morphology code in the cancer registry database. Women affected by uterine cancer and found death due to uterine cancer (International Classification of Diseases 9th edition code 182) in deaths certificate will be defined as death cases. Statistical Analyses The numbers of person-years at risk of developing and dying for uterine cancer will be calculated. Incidence rates will be calculated by dividing the number of uterine cancer cases by the person-years at risk of developing uterine cancer. Mortality rates will be calculated by dividing the number of uterine cancer deaths by the person-years at risk of dying from uterine cancer. The association between mortality and age, histology, time periods will be estimated through Kaplan-Meier survival analysis and Cox's proportional hazards model. It is defined as significant difference statistically when p value is less than 0.05.

Criteria for eligibility:

Study pop:
All uterine cancer patients in Taiwan between 1979-2008

Sampling method: Non-Probability Sample
Criteria:
Inclusion Criteria: - All uterine cancer patients in Taiwan between 1979-2008 Exclusion Criteria: - nil

Gender: Female

Minimum age: N/A

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: National Taiwan University Hospital

Address:
City: Taipei
Zip: 100
Country: Taiwan

Status: Recruiting

Contact:
Last name: Wen-Fang Cheng, Professor

Phone: 886-2-23123456

Phone ext: 71964
Email: wenfangcheng@yahoo.com

Start date: April 2011

Completion date: April 2013

Lead sponsor:
Agency: National Taiwan University Hospital
Agency class: Other

Source: National Taiwan University Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT01465737