Effect of Carum Carvi on Thyroid Hormones and TSH Level
Conditions
Thyroid Cancer Patients
Conditions: official terms
Thyroid Diseases - Thyroid Neoplasms
Conditions: Keywords
well differentiated thyroid cancer, Carum Carvi, Normal controls
Study Type
Interventional
Study Phase
Phase 1/Phase 2
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Intervention
Name: Carum Cravi Type: Drug
Name: Placebo Type: Drug
Overall Status
Recruiting
Summary
Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 65 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Age 18-65

- Hypothyroid patients under treatment with levothyroxin

- Normal euthyroid patients with no goiter

Exclusion Criteria:

- Pregnancy or lactation

- Severe lung or gasterointestinal disease

- Heart failure or renal failure
Location
Nuclear Medicine Department, Ghaem Hospital
Mashhad, Iran, Islamic Republic of
Status: Recruiting
Start Date
May 2011
Sponsors
Mashhad University of Medical Sciences
Source
Mashhad University of Medical Sciences
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page