Diffusion-weighted Imaging Study in Cancer of the Ovary
Conditions
Ovarian Cancer - Peritoneal Metastases
Conditions: official terms
Neoplasm Metastasis - Ovarian Neoplasms
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
This project seeks to develop a quantitative imaging biomarker for evaluating and monitoring treatment response in ovarian cancer metastases and assess its potential in monitoring treatment response. This will involve standardising DW-MRI for the abdomen and pelvis across multiple centres and platforms, assessing reproducibility of the measurement in patients planned for neoadjuvant chemotherapy and assessing its utility as an early response biomarker in patients with platinum-sensitive relapse due to receive therapy with carboplatin. Scanning measurements will be correlated with histopathological markers in tumour samples in order to link the biomarker with response mechanisms.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 80 Years
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- Histologically confirmed ovarian, primary peritoneal or fallopian tube cancer stage III or IV

- Scheduled to receive neoadjuvant chemotherapy (carboplatin/cisplatin)with planned debulking surgery.

Exclusion Criteria:

- Life expectancy of less than 6 months

- MRI contraindications

- Low grade or heavily calcified disease
Locations
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, Cambridgeshire, United Kingdom
Status: Recruiting
Contact: Sue Freeman, Dr - 01223 216911 - sue.freeman@addenbrookes.nhs.uk
Queen Elizabeth Hospital
Newcastle, Gateshead, United Kingdom
Status: Completed
The Institute of Cancer Research and Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom
Status: Recruiting
Contact: Nandita deSouza, Professor - 0208 661 3289 - nandita.desouza@icr.ac.uk
Singleton Hospital
Swansea, Wales, United Kingdom
Status: Recruiting
Contact: Kerryn Lutchman-Singh, Dr - kerryn.lutchman-singh@wales.nhs.uk
Imperial College Healthcare NHS Trust
London, United Kingdom
Status: Recruiting
Contact: Andrea Rockall, Professor - a.rockall@imperial.ac.uk
Mount Vernon Cancer Centre
Northwood, Middlesex, United Kingdom
Status: Recruiting
Contact: Marcia Hall, MBBS PhD FRCP - marcia.hall@nhs.net
Start Date
August 2012
Completion Date
December 2016
Sponsors
Institute of Cancer Research, United Kingdom
Source
Institute of Cancer Research, United Kingdom
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page