Non-Invasive Cerenkov Luminescence Imaging of Lymphoma, Leukemia and Metastatic Lymph Nodes
Head and Neck Cancers
Conditions: official terms
Head and Neck Neoplasms
Conditions: Keywords
18F-FDG PET/CT scan, 131I therapy, Cerenkov Luminescence Imaging, 12-050, Lymphoma, Leukemia, Metastatic Lymph Nodes
Study Type
Study Phase
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Name: Cerenkov emissions from the PET tracer 18F-FDG and the radiotherapeutic 131I
Type: Radiation
Overall Status
The purpose of this study is to see if a new way of imaging called the Cerenkov luminescence or effect that is used with a standard clinical PET/CT scans can be done in order to capture tumor sizes. The investigators believe endoscopies and surgical procedures could benefit from this type of imaging in the future. The Cerenkov imaging could be used as a guide for surgical resections.

The purpose of this study is to use the Cerenkov light from FDG or Iodine-131 tracers to image tumors and its sizes in the head, neck, breast, axillary and pelvic regions with a highly sensitive camera. The investigators will be trying to see if we can get another picture of the tumor using the Cerenkov light as part of the standard clinical scan or therapy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Participant is 18 years of age or older.

- Participant is scheduled for standard clinical 18F-FDG PET/CT scan or 131I therapy within the Nuclear Medicine Service at Main Hospital.

- Patients must have pathologic lymph node metastases in the neck, axillary or inguinal area (do not need to be biopsy proven) from either leukemias, lymphomas: , Head and Neck cancers (e.g. tonsillar, nasopharynx, tongue carcinoma, breast cancer or melanoma;or lymphoma or tonsillar or squamous cell carcinoma with metastases in the neck region for PET/CT imaging, or thyroid cancer for thyroid ablation therapy. Any other more infrequent cancer metastasizing with nodal metastasis in the neck, axilla and inguinal regions to cervical lymph nodes is eligible as well as the primary goal is to image pathological (i.e. hypermetabolic) lymph nodes.

- Patients with hypermetabolic activity and uptake in the neck,axilla, breast and inguinal region on scan, defined visually as significant lesion suspicious for malignancy by a nuclear medicine physician or trainee.

Exclusion Criteria:

- Patients imaged for Cerenkov luminescence are going to be required to be in a darkened enclosure for at least 10 minutes and sit still during image acquisition, potentially covered by a dark cloth in case that the ambient light level remains too high for the ultra-sensitive camera. Any conditions that would prevent this will exclude the patients.

- There are no other past medical, physiological or demographic concerns. This includes any patients with skin blemishes that are present at the dermis over the tumor, as these are of particular interest for use of this technique.
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Status: Recruiting
Contact: Jan Grimm, MD, PhD - 646-888-3095
Start Date
August 2012
Completion Date
August 2016
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Record processing date processed this data on July 28, 2015 page