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Perioperative Immunonutrition, Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients
Conditions
Gastric Cancer
Conditions: official terms
Stomach Neoplasms
Conditions: Keywords
malnutrition,, perioperative artificial nutrition,, immunonutrition,, gastrectomy,, lymphocytes,, interleukin,, blood platelets,, phagocytic and bactericidal activity of blood platelets
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Intervention
Name: Early postoperative enteral nutrition, based on standard elementary diet (Peptisorb)
Type: Dietary Supplement
Name: glutamine
Type: Drug
Name: oral diet enriched with arginine (Cubitan)
Type: Dietary Supplement
Name: Perioperative parenteral immunonutrition (Dipeptiven, Omegaven)
Type: Drug
Overall Status
Recruiting
Summary
Perioperative immunonutrition in gastric cancer patients can reduce perioperative morbidity and may improve quality of their life. Patients with gastric cancer will be divided into four groups depending on the type of artificial nutrition. Group I (enteral feeding) and II (enteral feeding and parenteral nutrition with glutamine) will be administered nutritional therapy during the postoperative period, group III (oral arginine) and IV (parenteral immunonurition) patients will be treated nutritionally both prior to and after the surgery. The lymphocytes and their subpopulations, interleukin IL-1B,-6,-23, and the phagocytic, and bactericidal activity of blood platelets will be determined before and after nutritional therapy.
Detailed Description
Surgical treatment of gastric cancer is associated with a high risk of perioperative complications. Morbidity of cancer patients increases in concert with the clinical stage of the malignancy. It is postulated that a reduction in perioperative morbidity and improved quality of life of patients with advanced gastric cancer can be achieved by proper preparation to surgery, among others. One of such methods is the implementation of immunostimulating nutritional therapy during the perioperative period.The stage of cancer will be graded according to TNM classification. The patients will be randomly assigned to four clinical groups based on the type of nutritional therapy implemented.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:
- gastric cancer
Exclusion Criteria:
- for group III constituted gastric cancer associated with severe gastrointestinal obstruction
- gastric cancer
Exclusion Criteria:
- for group III constituted gastric cancer associated with severe gastrointestinal obstruction
Location
Medical University of Bialystok
Bialystok, Podlaskie, Poland
Status: Recruiting
Contact: Zbigniew Kamocki, MD PhD - +48606452246 - zkamocki@yahoo.com
Start Date
March 2007
Completion Date
July 2017
Sponsors
Medical University of Bialystok
Source
Medical University of Bialystok
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
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