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Letrozole and CDK 4/6 Inhibitor for ER Positive, HER2 Negative Breast Cancer in Postmenopausal Women
Conditions
ER Positive, HER2 Negative Breast Cancer
Conditions: official terms
Breast Neoplasms
Study Type
Interventional
Study Phase
Phase 2
Study Design
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Letrozole, PD 0332991
Type: Drug
Overall Status
Recruiting
Summary
This is a phase II study evaluating the efficacy and safety of the pre-operative use of letrozole plus PD 0332991 (combination therapy)
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:
- Postmenopausal women
- Primary tumor greater than 2 cm in diameter
- Histologically proven invasive breast cancer
- Positive estrogen receptor
- Negative HER-2 receptor
- ECOG performance status ≤ 1 or Karnofsky performance status ≥ 70%
- Laboratory values must be follows:
Absolute neutrophil count ≥ 1,500/mm3; Platelets ≥ 100,000/mm3; Hemoglobin ≥ 9 g/dL; Bilirubin ≤ 1.5 × institutional upper limit of normal (ULN); Serum Creatinine ≤ 1.5 × ULN; Alkaline phosphatase ≤ 2 × ULN; AST and ALT ≤ 2 × ULN; Normal finding of ECG - QTc ≤ 470 msec (based on the mean value of the triplicate ECGs); Left ventricular ejection fraction (LVEF) ≥ 60%.
- Able to give written informed consent form
- Able to follow prescription instructions reasonably well
Exclusion Criteria:
- Male
- Severe psychiatric disorder
- Prior history of other malignancy within 5 years of study entry, aside from basal cell carcinoma or the skin or carcinoma-in-situ of the uterine cervix
- Locally advanced breast cancer (T3N1 or Any T4 or Any N2, N3), or distant metastasis
- Multifocal or multicentric breast cancer except that the largest lesion is greater than 2cm
- Major surgery within 3 weeks of first study treatment
- Current use or anticipated need for:
Food or drugs that are known strong CYP3A4 inhibitors; drugs that are known strong CYP3A4 inducers
- Severe cardiovascular diseases in the previous 6 months
- Active inflammatory bowel disease or chronic diarrhea
- Renal Impairment
- Poor adrenal function
- Hepatitis B and/or hepatitis C carriers (unless with normal hepatic function)
- Known human immunodeficiency virus infection
- Known hypersensitivity to anti-aromatase drugs or any cell cycle inhibitor
- Other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that would impart, in the judgment of the investigator, excess risk associated with study participation or study drug administration, or which, in the judgment of the investigator, would make the patient inappropriate for entry into this study
- Postmenopausal women
- Primary tumor greater than 2 cm in diameter
- Histologically proven invasive breast cancer
- Positive estrogen receptor
- Negative HER-2 receptor
- ECOG performance status ≤ 1 or Karnofsky performance status ≥ 70%
- Laboratory values must be follows:
Absolute neutrophil count ≥ 1,500/mm3; Platelets ≥ 100,000/mm3; Hemoglobin ≥ 9 g/dL; Bilirubin ≤ 1.5 × institutional upper limit of normal (ULN); Serum Creatinine ≤ 1.5 × ULN; Alkaline phosphatase ≤ 2 × ULN; AST and ALT ≤ 2 × ULN; Normal finding of ECG - QTc ≤ 470 msec (based on the mean value of the triplicate ECGs); Left ventricular ejection fraction (LVEF) ≥ 60%.
- Able to give written informed consent form
- Able to follow prescription instructions reasonably well
Exclusion Criteria:
- Male
- Severe psychiatric disorder
- Prior history of other malignancy within 5 years of study entry, aside from basal cell carcinoma or the skin or carcinoma-in-situ of the uterine cervix
- Locally advanced breast cancer (T3N1 or Any T4 or Any N2, N3), or distant metastasis
- Multifocal or multicentric breast cancer except that the largest lesion is greater than 2cm
- Major surgery within 3 weeks of first study treatment
- Current use or anticipated need for:
Food or drugs that are known strong CYP3A4 inhibitors; drugs that are known strong CYP3A4 inducers
- Severe cardiovascular diseases in the previous 6 months
- Active inflammatory bowel disease or chronic diarrhea
- Renal Impairment
- Poor adrenal function
- Hepatitis B and/or hepatitis C carriers (unless with normal hepatic function)
- Known human immunodeficiency virus infection
- Known hypersensitivity to anti-aromatase drugs or any cell cycle inhibitor
- Other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that would impart, in the judgment of the investigator, excess risk associated with study participation or study drug administration, or which, in the judgment of the investigator, would make the patient inappropriate for entry into this study
Location
Unimed Medical Institute
Hong Kong, China
Status: Recruiting
Contact: Louis Chow, MD - (852)28610286
Start Date
February 2012
Sponsors
Organisation for Oncology and Translational Research
Source
Organisation for Oncology and Translational Research
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
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