Mechanisms of Immunosurveillance for Lung Cancer
Conditions
Lung Cancer
Conditions: official terms
Lung Neoplasms
Conditions: Keywords
Immunoregulation, Natural Killer Cells
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Intervention
Name: blood draw
Type: Other
Overall Status
Recruiting
Summary
The purpose of this research study is to investigate the differences in "natural killer (NK) blood cells, a type of white blood cell that fights infection in the body, among different types of patients that have lung surgery. The four different groups of patients are:

- smokers with lung cancer

- smokers without lung cancer

- non-smokers with lung cancer

- non-smokers without lung cancer.
Detailed Description
Research has shown that different strains of mice possess varying susceptibility to lung cancer. C3H and C57BL6 mice are highly resistant to lung cancer, whereas A/J and 129 mice are very susceptible to lung cancer. Data from our lab shows that the mice have different numbers of natural killer (NK) cells as well as different characteristics of those cells. C3H and C57BL6 mice have higher numbers of NK cells as well as higher expression of CD11b, whereas A/J and 129 mice have lower numbers and lower expression.

These findings justify parallel investigation of NK cells in human populations resistant and susceptible to lung cancer. Through blood samples, circulating NK cells can be counted and phenotypically analyzed. Smoking can be used as a factor to establish lung cancer risk. Additionally, non-smokers suffering from lung cancer provide an opportunity to investigate whether lung cancer patients have lower abundance of NK cells and lesser expression of CD11b, independent of the effects of smoking.

Objective:

The main goal of this study is to investigate the quantitative and phenotypic differences in circulating NK cells among human populations. Participants will be classified as heavy smokers (HS), non-smokers (NS), those suffering from lung cancer (LC), and those free from lung cancer (NC).

Hypothesis #1: NS/LC participants will have fewer NK cells and lower expression of CD11b compared to HS/NC and NS/NC participants.

Hypothesis #2: NS/LC participants will have more numerous NK cells and higher expression of CD11b compared to HS/LC participants.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Age equal or greater to 18 years

- Ability to read and write in English

- Able to participate in the informed consent process

Exclusion Criteria:

- Known active hepatitis B, hepatitis C, or HIV/AIDs (found in medical record)

- Chemotherapy or radiation therapy within 3 months of enrollment

- Type 1 Diabetes Mellitus

- Rheumatoid arthritis, Lupus, Multiple Sclerosis, or any other autoimmune disease as deemed necessary for exclusion by the Principal Investigator

- Previous organ transplant

- Blood transfusion within 3 months prior to enrollment

- Any previous cancer, excluding a previous lung cancer

- Steroid use within 4 weeks of enrollment
Location
Washington University School of Medicine
St. Louis, Missouri, United States
Status: Recruiting
Contact: Christine R Frederiksen, MS - 314-362-2412 - frederiksenc@wudosis.wustl.edu
Start Date
September 2012
Completion Date
September 2016
Sponsors
Washington University School of Medicine
Source
Washington University School of Medicine
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page