Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer
Conditions
Hypothyroidism
Conditions: official terms
Hypothyroidism - Thyroid Neoplasms
Conditions: Keywords
thyroid cancer, hypothyroidism, metabolic parameters, Hypothyroidism after levothyroxine withdrawal
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
Recruiting
Summary
1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy.

2. Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters.

3. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.
Detailed Description
1. Study design measurement of various parameters during hypothyroid state (before 1 month, the day and after 1 month of RAI therapy)

2. Measurements

1. Measurement of metabolic and cardiovascular parameters

- glucose profiles : HbA1c, fasting glucose level

- lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride

- adipocytokines : retinol binding protein(RBP)

- 4, leptin, resistin, adiponectin

- markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)

- bone turnover markers : CTX, bone ALP

2. Scoring of symptoms and signs of hypothyroidism (Zulewski score)

- symptoms

- physical signs
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 80 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- radioiodine therapy after total thyroidectomy in differentiated thyroid cancer

- age over 18

Exclusion Criteria:

- kidney failure, liver failure, heart failure

- infection

- inflammation

- autoimmune disease

- other chronic disease
Location
Konkuk University Medical Center
Seoul, Korea, Republic of
Status: Recruiting
Contact: Jee Hyun An - 82-10-9089-4655 - jeehyunan@gmail.com
Start Date
July 2012
Completion Date
May 2013
Sponsors
Konkuk University Medical Center
Source
Konkuk University Medical Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page