Intraoperative MRI and 5-ALA Guidance to Improve the Extent of Resection in Brain Tumor Surgery
Primary Malignant Neoplasm of Nervous System - Glioma - Glioblastoma - Metastasis
Conditions: official terms
Brain Neoplasms - Neoplasms - Nervous System Neoplasms
Conditions: Keywords
primary brain tumor, malignant glioma, intraoperative MRI, 5-ALA
Study Type
Study Phase
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Name: Interventional arm Type: Procedure
Name: Control arm Type: Procedure
Overall Status
Not yet recruiting
The investigators hypothesize that the rate of radiologically complete resections of contrast-enhancing brain tumors following surgeries aided by use of 5-ALA induced fluorescence guidance and use of an intraoperative ultra-low field MRI is higher compared to surgeries aided by 5-ALA induced fluorescene alone.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- adult patient (> 18 years) able to give informed consent

- primary supratentorial intra-axial brain tumor exhibiting contrast enhancement suspected to be malignant glioma

- tumor must be deemed completely resectable by neurosurgeon

- diagnostic MRI

Exclusion Criteria:

- patient unable or unwilling to give informed consent

- infratentorial tumor location

- tumor location in or near eloquent areas

- multifocal tumor

- existance of contraindications to undergo MRI examination

- previous surgical treatment for an intraaxial brain tumor
Klinik für Neurochirurgie Johann Wolfgang Goethe University
Frankfurt am Main, Hessen, Germany
Status: Recruiting
Contact: Christian Senft, MD PhD - 069-6301 -
Start Date
March 2013
Completion Date
February 2016
Johann Wolfgang Goethe University Hospitals
Johann Wolfgang Goethe University Hospitals
Record processing date processed this data on July 28, 2015 page