Study of Weekly Radiotherapy for Bladder Cancer

Trial Title: Study of Weekly Radiotherapy for Bladder Cancer

NCT ID: NCT01810757

Condition: Bladder Cancer

Conditions: Official terms:
Urinary Bladder Neoplasms

Study type: Interventional

Study phase: N/A

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Radiation
Intervention name: Standard planning radiotherapy
Description: 36 Gray dose given in 6 fractions of 6 Grays over 6 weeks, using one plan per patient.
Arm group label: Standard planning

Intervention type: Radiation
Intervention name: Adaptive planning radiotherapy
Description: 36 Gray dose given in 6 fractions of 6 Grays over 6 weeks, selecting the best fit from three plans per patient.
Arm group label: Adaptive planning

Summary: Background Localised muscle invasive bladder cancer (MIBC) is life-threatening and can cause significant symptoms. Around 50% of patients with MIBC who are referred for radiotherapy are unfit for standard radical treatment (surgery or daily radiotherapy with chemotherapy), but would have a normal life expectancy if their cancer were adequately controlled. Retrospective studies suggest that radiotherapy which is given weekly using fewer fractions and higher doses (hypofractionated), may be an alternative where daily radiotherapy is not an option. Radiotherapy treatment is planned based on information from a CT scan which shows the position and shape of the bladder. This plan needs to take into account the fact that the bladder's shape and position can change, depending on how full it is and because of where it is in relation to the bowel. A safety margin is therefore added around the bladder on the planned treatment, to reduce the risk of missing any of the bladder with the radiotherapy. It is now possible to take scans of the bladder's position before each treatment and adjust the position of the treatment plan accordingly to ensure the bladder is fully covered by it. In this study we are also looking at whether it is possible to design a series of treatment plans with different size safety margins and then choose one that fits best for each particular day. This is called 'adaptive radiotherapy'. This technique may enable accurate treatment delivery using smaller safety margins and this might help to reduce side effects. Aims In patients with MIBC not suitable for cystectomy or daily radiotherapy we aim to assess: 1. whether treatment using adaptive planning can be successfully delivered at multiple sites across the UK and results in acceptable levels of toxicity 2. the local tumour control rate achieved by hypofractionated weekly radiotherapy 3. the requirement to treat with adaptive planning. How results will be used Results will provide robust evidence for use of hypofractionated radiotherapy and assess whether this is a plausible and worthwhile treatment in this patient population. The randomised element of the trial will support the implementation of image-guided adaptive radiotherapy for bladder cancer in the UK. HYBRID will provide evidence on the benefits or otherwise of this methodology and inform the development of further trials in this and other patient groups.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Written informed consent - Age ≥18 years - Histologically confirmed invasive bladder carcinoma (T2-T4a N0 M0; any histological sub-type) - Unsuitable for radical cystectomy or daily fractionated radiotherapy for any reason (including performance status, co-morbidity, patient refusal) - Expected survival >6 months - WHO performance status 0-3 - Willing to undergo post treatment cystoscopy Exclusion Criteria: - Nodal or metastatic disease - Concurrent malignancy - Previous pelvic radiotherapy - Urinary catheter in-situ - Any other contra-indication to radiotherapy (e.g. inflammatory bowel disease) - Unable to attend for post treatment follow up

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Addenbrooke's Hospital

Address:
City: Cambridge
Country: United Kingdom

Facility:
Name: Velindre Cancer Centre

Address:
City: Cardiff
Country: United Kingdom

Facility:
Name: Ipswich Hospital

Address:
City: Ipswich
Country: United Kingdom

Facility:
Name: St James's University Hospital

Address:
City: Leeds
Country: United Kingdom

Facility:
Name: Guy's & St Thomas's Hospital

Address:
City: London
Country: United Kingdom

Facility:
Name: Royal Marsden NHSFT

Address:
City: London
Country: United Kingdom

Facility:
Name: University College London

Address:
City: London
Country: United Kingdom

Facility:
Name: Norfolk & Norwich University Hospitals NHS Foundation Trust

Address:
City: Norwich
Country: United Kingdom

Facility:
Name: Royal Preston Hospital

Address:
City: Preston
Country: United Kingdom

Facility:
Name: Queens Hospital

Address:
City: Romford
Country: United Kingdom

Facility:
Name: Clatterbridge Cancer Centre

Address:
City: Wirral
Country: United Kingdom

Start date: April 2014

Completion date: January 2025

Lead sponsor:
Agency: Institute of Cancer Research, United Kingdom
Agency class: Other

Collaborator:
Agency: Cancer Research UK
Agency class: Other

Source: Institute of Cancer Research, United Kingdom

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT01810757