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Trial Title:
Body Composition Analysis for Patient With Lung Cancer Using Computed Tomography Image Analysis
NCT ID:
NCT01887769
Condition:
Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Conditions: Keywords:
Lung cancer
Body composition analysis
Ct-Scan
Muscle mass
Cachexia
Study type:
Observational
Overall status:
Unknown status
Study design:
Time perspective:
Retrospective
Summary:
Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung
cancer is the leading cancer-related death worldwide and it represents a pressing health
issue. Patients with lung cancer are more likely to experience cachexia, a severe
debilitating disorder causing fatigue, weight loss, muscle wasting and associated with
reduced physical function, increased chemotherapy toxicity and reduced survival. This
syndrome occurring in about 80% of advanced cancer patients is the direct cause of death
in about 20% of cases. However, despite the importance of cachexia in lung cancer, it has
been mainly studied from several assessment methods which do not usually differentiate
muscle from other tissues.
Aim: To analyze body composition of patients with lung cancer at diagnosis using computed
tomography (CT-Scan) image analysis.
Methods: This is a retrospective study extending over a period of 3 years conducted at
the Institut universitaire de cardiologie et de pneumologie de Québec (2009-2012). We
listed patients newly diagnosed with lung cancer who had a thoraco-abdominal CT-scan
performed in our institution. Following the collection of clinical data from patient
records, we used SliceOmatic software to quantify muscle area, visceral fat area and
subcutaneous fat area from a single abdominal cross-sectional image at the level of the
third lumbar vertebra.
Criteria for eligibility:
Study pop:
Lung cancer patients, at diagnosis, following in oncology clinic
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Men or women
- Between 40-80 years of age
- Primary lung cancer diagnosed between 2009 and 2012
- CT-Scan done at the time of the diagnosis
Exclusion Criteria:
- Chemotherapy, radiotherapy or surgery at the time of the first Ct-Scan image
- History of other cancer (during the last five years)
Gender:
All
Minimum age:
40 Years
Maximum age:
80 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Institut universitaire de cardiologie et de pneumologie de Québec
Address:
City:
Québec
Zip:
G1V 4G5
Country:
Canada
Status:
Recruiting
Contact:
Last name:
Didier Saey, PhD
Phone:
418-656-8711
Phone ext:
2614
Email:
didier.saey@criucpq.ulaval.ca
Investigator:
Last name:
Didier Saey, PhD
Email:
Principal Investigator
Start date:
May 2012
Completion date:
October 2017
Lead sponsor:
Agency:
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Agency class:
Other
Source:
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT01887769
