MRI FDG PET Imaging Cervix
Cervical Cancer Squamous Cell
Conditions: official terms
Neoplasms, Squamous Cell - Uterine Cervical Neoplasms
Conditions: Keywords
Cervical Cancer, PET Scan for cervix, MRI for cervix
Study Type
Study Phase
Study Design
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Type: Biological
Overall Status
The standard treatment for cervix cancer at Princess Margaret Hospital is external radiation with chemotherapy followed by internal radiation, called brachytherapy. Currently, brachytherapy treatment is planned on a type of Magnetic Resonance Imaging (MRI) called T2-weighted (T2W) MRI.

The main purpose of this study is to determine whether the following imaging tests can visualize the tumor better for planning the brachytherapy treatment:

1. special types of MRI called diffusion weighted MRI (DWI) and dynamic-contrast enhanced MRI (DCE-MRI); and

2. an x-ray test called positron emission test (PET) performed with a sugar dye called FDG. MRI-guided brachytherapy is resource-intensive and not widely available.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

1. Age ≥ 18 years

2. Histologic diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix

3. FIGO Stage IB - IVA

4. Intention to treat using radiotherapy with or without concurrent cisplatin chemotherapy according to the current treatment policies of the PMH Gynecology Group

5. Intention to treat with MR-guided brachytherapy as part of standard radiotherapy according to the current treatment policies of the PMH Gynecology Group

6. No cytotoxic anti-cancer therapy for cervix cancer prior to study entry

7. A negative urine or serum pregnancy test within the two week interval immediately prior to the first PET-CT imaging, in women of child-bearing age

8. Ability to provide written informed consent to participate in the study

Exclusion Criteria:

1. Prior complete or partial hysterectomy

2. Carcinoma of the cervical stump

3. Inability to lie supine for more than 30 minutes

4. Insulin-dependent diabetes mellitus

5. Impaired kidney function with glomerular filtration rate < 30

6. Previous anaphylactic reaction to gadolinium or other contraindications to MR.
University Health Network, The Princess Margaret
Toronto, Ontario, Canada
Status: Recruiting
Contact: Kathy Han, MD - 416 946 4501 -
Start Date
October 2012
Completion Date
October 2016
University Health Network, Toronto
University Health Network, Toronto
Record processing date processed this data on July 28, 2015 page