Analysis of Plasma Tumor DNA in Lung Cancer Patients
Conditions
Non Small Cell Lung Cancer Patients
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
lung cancer, plasma DNA, free DNA, EGFR, ALK
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
Recruiting
Summary
The presence of genetic alterations in the tyrosine kinase domain of the oncogene (eg. EGFR and ALK) is associated with the clinical response to tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancers. Therefore, the detection of altered genetic alterations is useful for predicting the treatment response for TKIs in non-small cell lung cancer patients. However, good quality tumor tissues are available only in <50% of patients with inoperable lung cancer for mutation analysis. In this study, the investigators will detect and quantify the genetic alterations in plasma. the investigators will investigate if the serial measurement of cancer-derived genetic alterations in plasma can provide a means for monitoring disease progression, as well as treatment response. In addition the investigators will analysis the resistant mechanism of TKIs and chemotherapy with plasma tumor DNA.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- Have a histologically or cytologically confirmed diagnosis of non-small cell lung cancer

- Have molecular evidence of genetic alterations in tumor sample (eg. EGFR mutations, ALK fusions)

- Patients must have given written informed consent

Exclusion Criteria:

- Patients who refuse the blood samplings
Location
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of
Status: Recruiting
Contact: Hyun , Chang - 82-31-787-7039 - mobitz@hanmail.net
Start Date
July 2013
Sponsors
Seoul National University Hospital
Source
Seoul National University Hospital
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page