Correlation Research of Thioredoxin Reductase in Lung Cancer
Non-small Cell Lung Cancer - Benign Neoplasm of Lung
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
thioredoxin reductase, non-small cell lung cancer
Study Type
Study Phase
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
In pre-clinical study the investigators found that the thioredoxin reductase activity of serum harbours huge difference between cancer patients and non-cancer patients, the enzyme activity elevated remarkably among cancer patients, so the investigators hypothesis that this is due to tumor cells loading of the patients, the enzyme activity may harbours huge difference between carcinoma tissues and para-carcinoma tissues in early staged non-small cell lung cancers, and after surgery, the enzyme activity may fall down to a normal level because of removing of tumor.
Detailed Description
This is a cooperative research project in Thoracic Surgery Department and Medical Oncology Department of Affiliated Cancer Hospital of xiangya School of Medicine Central South University, and the State Key Laboratory for Natural Medicine and Biomimetic Drugs Perking University. The primary objective is to measure the thioredoxin reductase activity using blood and lung cancer tissue and measure thioredoxin reductase messenger ribonucleic acid (mRNA) and protein expression using lung cancer and pericarcinomatous tissue in early staged(Ⅰ~ⅢA) non-small lung cancers, to study the correlations of thioredoxin reductase between blood and tissue. The secondary objectives are to measure the thioredoxin reductase activity between non small lung cancers and lung benign lesion patients to identify the difference between tumor and lung benign mass.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 80 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Pathologically proven staged(Ⅰ~ⅢA) non-small cell lung cancer or CT scan shows resectable lung mass

- Receive surgery in Thoracic Oncology department Hunan Tumor Hospital without contraindication of surgery

- Malignant tumor treatment naive(except for surgery for cervical cancer and cutaneous squamous cell carcinoma 5 years before)

- Signed informed consent about providing blood and tissue for study

Exclusion Criteria:

- Patients have received antitumor treatment

- Patients with contraindication of surgery or patients who need adjuvant chemotherapy with contraindication of chemotherapy

- Pregnant or breast feeding women
Hunan Provincal Tumor Hospital
Changsha, Hunan, China
Status: Recruiting
Contact: Ming Zhou - +86 731 89762320 -
Start Date
May 2013
Completion Date
October 2015
Hunan Province Tumor Hospital
Hunan Province Tumor Hospital
Record processing date processed this data on July 28, 2015 page