Metabolic Tumor Volumes in Radiation Treatment of Primary Brain Tumors
Conditions
Brain Tumor - Glioblastoma Multiforme
Conditions: official terms
Brain Neoplasms - Glioblastoma
Conditions: Keywords
Brain Tumor, Glioblastoma multiforme, GBM, Metabolic Tumor Volume, MTV, Clinical Tumor Volume, CTV
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
- Metabolic Tumor Volume (MTV), identified by Magnetic Resonance Spectroscopic Imaging (MRSI) is different from the Clinical Target Volume (CTV) used for radiation dose delivery in the treatment of brain tumors.

- If MTV > CTV, the investigators hypothesize that the difference in volumes (cc) is related to worse clinical outcome. Furthermore, in case of local recurrence, the lesion is located in the MTV area that is outside of the CTV.

- Alternatively, if CTV > MTV, then the difference in volumes is related to higher treatment toxicity.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Patients must have histologically confirmed primary brain tumor.

- Patients may be enrolled prior to surgery, after surgical resection or with unresectable tumors.

- Patients must be 18 years or older.

- Patients who do not have metal in the body (e.g. pacemakers, implants) that would preclude them from undergoing MRI/MRS exam

- Patients who do not suffer from claustrophobia (fear of enclosed spaces)

- Karnofsky performance status ≥ 60.

- Patients whose size would allow them to fit into the bore of the MRI instrument.

- Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

- Patients younger than 18 years.

- Inability to undergo MRI/MRS exam because of metal in the head or body, such as implants, pacemaker, or biostimulation device. Claustrophobia (fear of enclosed spaces).

- Karnofsky performance status < 60.

- Patients too large (> 300 lbs.) to fit into the bore of the MRI instrument.

- Inability to understand the informed consent document.
Location
University of Miami
Miami, Florida, United States
Status: Recruiting
Contact: Radka Stoyanova, PhD - 305-243-5856 - RStoyanova@med.miami.edu
Start Date
January 2011
Sponsors
University of Miami
Source
University of Miami
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page