The Effect of Different Doses of Remifentanil on Kidney Function During Robot Assisted Prostatectomy - A Retrospective Study
Conditions
Prostate Cancer
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Retrospective
Overall Status
Recruiting
Summary
Robot assisted prostatectomy reduces the patients' postoperative pain and leads to rapid rehabilitation. But pneumoperitoneum affects the kidney. The increase of stress hormone reduces the glomerular filtration and the vaso-contraction of renal vessels leads the renal ischemia. Remifentanil is analgesics coupled with μ opioid receptor. In high dose of remifentanil, it is associated with κ and δ receptors, which leads to renal protection effect in animal study. Also, remifentanil infusion during anesthesia showed a diuretic effect. The purpose of this study is to investigate the remifentanil effect on renal function during robot assisted prostatectomy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 85 Years
Minimum Age: 20 Years
Gender: Male
Criteria: Inclusion Criteria:

- ages > 19 years and < 85 years

- the patients undergoing a general anesthesia for robot assisted prostatectomy

Exclusion Criteria:

- incomplete record

- history of opioid or steroid using

- solitary kidney

- history of kidney transplantation
Location
Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of
Status: Recruiting
Contact: Ji Eun Kim, MD - 82-2-2019-6808 - beye98@yuhs.ac
Start Date
January 2014
Completion Date
December 2014
Sponsors
Yonsei University
Source
Yonsei University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page