Study on Neoadjuvant Chemotherapy for Advanced Gastric Cancer
Conditions
Advanced Gastric Carcinoma
Conditions: official terms
Stomach Neoplasms
Conditions: Keywords
advanced gastric cancer, neoadjuvant chemotherapy, safety, feasibility
Study Type
Interventional
Study Phase
Phase 2
Study Design
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: paclitaxel liposome
Type: Drug
Overall Status
Not yet recruiting
Summary
Gastric cancer is the second cause of cancer related death and China has the most gastric cancer patients in the world. Although systemic strategies, including adjuvant chemotherapy, postoperative chemoradiotherapy, perioperative chemotherapy, have evolved and showed benefits these years, the prognosis of advanced gastric cancer is still not satisfactory. Optimal regimens and optimal method administration is still being found. Neoadjuvant chemotherapy has many advantages, including downstaging the tumor, increasing R0 rate, early eradicating of micrometastasis. In previous trials, combination of paclitaxel and s-1 has showed safety and tolerance in recurrent or metastatic gastric cancer. Using liposome as a carrier, paclitaxel has a better histocompatibility and cellular affinity, resulting a improved stability and reduced toxicity. In this phase II trial, we are going to study the safety and feasibility of paclitaxel liposome plus s-1 as neoadjuvant chemotherapy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 75 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically confirmed gastric cancer

- Disease at clinical stage of resectable or potentially resectable(T3-4, N0-3, M0) by CT and endoscopic ultrasonography (EUS)

- Karnofsky performance status(KPS) ≥ 70

- No prior antitumor treatment is allowed, including chemotherapy, radiotherapy, immune therapy or target therapy

- Life expectancy more than 3 months

- Adequate organ function as defined below:White Blood Cell Count (WBC) ≥ 3.0*10^9/l, Absolute Neutrophil Count (ANC) ≥ 1.5*10^9/l, Hemoglobin ≥ 100 g/l, Platelets ≥ 100*10^9/l, Total Bilirubin (TBIL) ≤ 1.5mg/dl, Aspartate Aminotransferase(AST) and Alanine Aminotransferase(ALT) ≤ 2.5×ULN, Alkaline pPosphatase( ALP) ≤ 2.5×ULN, Renal Serum Creatinine < 1.5mg/dl

- Adequate lung and heart function

Exclusion Criteria:

- ≥ grade 2 neuropathy

- History of malignancy

- With uncontrolled central nervous system metastasis

- Concurrent disease or condition that would interfere with the subject's safety (including current active hepatic, biliary, renal, respiratory disease, acute infection, severe malnutrition, uncontrolled diabetes hypertension et al)

- Severely inadequate intake of water or diet
Location
Peking University Cancer Hospital
Haidian District, Beijing, China
Status: Not yet recruiting
Contact: Ziyu Li, M.D. - ligregory369@hotmail.com
Start Date
December 2013
Completion Date
December 2014
Sponsors
Peking University
Source
Peking University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page