Ovarian Malignancy Incidence in Moderate Risk Women With Low CA 125
Ovarian Cancer
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Retrospective
Name: Risk of malignancy index
Type: Other
Overall Status
The investigators are assessing the incidence of ovarian cancer in premenopausal women who were at moderate risk of malignancy with low CA125.
Detailed Description
About 10% of premenopausal women may have a surgery for ovarian masses. In premenopausal women the incidence of ovarian malignancy is 1:1000 in case of symptomatic ovarian cyst.1 CA125 is unreliable in differentiating benign from malignant ovarian mass in premenopausal women due to many false positive results and reduced specificity.1 pelvic vaginal ultrasonography is the most effective tool in evaluating ovarian masses due to increased sensitivity over abdominal US.1 An estimation of risk of malignancy index is essential in evaluating an ovarian mass.26 /2 Risk of malignancy index combines presurgical features serum including CA125, menopausal status and ultrasound findings. RMI=Ux Mx CA125 in which each feature takes a score and after calculation score less than 25 is mild, from 25-250 moderate and more than 250 has a severe risk of malignancy needing oncologist.44/3
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 50 Years
Minimum Age: 45 Years
Gender: Female
Criteria: Inclusion Criteria:

- Women with complex ovarian cyst

- Abdominal pain

- Menometrorrhagia

Exclusion Criteria:

- Significant weight loss

- Cachexia

- History of ovarian or other malignancy

- Family history of ovarian Cancer
Beni-Suef University
Beni-Suef, Egypt
Status: Recruiting
Contact: Nesreen A Shehata, MD - 00201227866337 - nesoomar@yahoo.com
Start Date
January 2014
Completion Date
April 2015
Beni-Suef University
Beni-Suef University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page