Evolution of Resistance to Systemic Therapies in Patients With Breast Cancer
Conditions
Metastatic Breast Cancer
Conditions: official terms
Breast Neoplasms
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Intervention
Name: n/a - observational
Type: Genetic
Overall Status
Not yet recruiting
Summary
The objective of this study is to apply Whole-body DW imaging alongside the routine management of patients requiring systemic therapy for metastatic breast cancer to compare the time to progression of individual liver metastases within and between patients following stable disease or partial response to palliative systemic therapy for breast cancer.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Age over 18 years.

- First metastatic breast cancer relapse after treatment for early stage disease

- A minimum of 10 evaluable lesions in the liver on routine x-ray CT imaging

- Patient prescribed cytotoxic, endocrine or biological therapies

- Patient physically and psychologically fit enough to consider sequential WB-- - DWI imaging alongside their standard disease monitoring

- Written informed consent

Exclusion Criteria:

- Diagnosis of other cancer within the last 5 years, other than resected non-melanoma skin cancer or cervical intraepithelial neoplasia

- Diagnosis of brain metastases.

- Contraindication to magnetic resonance MR imaging
Location
Start Date
December 2014
Completion Date
November 2016
Sponsors
Institute of Cancer Research, United Kingdom
Source
Institute of Cancer Research, United Kingdom
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page