A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

Trial Title: A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

NCT ID: NCT04194944

Condition: Non-Small Cell Lung Cancer

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Carboplatin
Pembrolizumab
Pemetrexed

Conditions: Keywords:
targeted therapy

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Selpercatinib
Description: Administered orally
Arm group label: Selpercatinib - Treatment A (TRT A)

Other name: LY3527723

Other name: LOXO-292

Intervention type: Drug
Intervention name: Carboplatin
Description: Administered IV
Arm group label: Pemetrexed and Platinum with or without Pembrolizumab - (TRT B)

Intervention type: Drug
Intervention name: Cisplatin
Description: Administered IV
Arm group label: Pemetrexed and Platinum with or without Pembrolizumab - (TRT B)

Intervention type: Drug
Intervention name: Pemetrexed
Description: Administered IV
Arm group label: Pemetrexed and Platinum with or without Pembrolizumab - (TRT B)

Intervention type: Drug
Intervention name: Pembrolizumab
Description: Administered IV
Arm group label: Pemetrexed and Platinum with or without Pembrolizumab - (TRT B)

Summary: The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have the option to potentially crossover to selpercatinib.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Histologically or cytologically confirmed, Stage IIIB-IIIC or Stage IV non-squamous NSCLC that is not suitable for radical surgery or radiation therapy. - A RET gene fusion in tumor and/or blood from a qualified laboratory. - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. - Adequate hematologic, hepatic and renal function. - Willingness of men and women of reproductive potential to observe conventional and highly effective birth control for the duration of treatment and for 6 months after. - Ability to swallow capsules. Exclusion Criteria: - Additional validated oncogenic drivers in NSCLC if known. - Prior systemic therapy for metastatic disease. Treatment (chemotherapy, immunotherapy, or biological therapy) in the adjuvant/neoadjuvant setting is permitted if it was completed at least 6 months prior to randomization. - Major surgery within 3 weeks prior to planned start of selpercatinib. - Radiotherapy for palliation within 1 week of the first dose of study treatment or any radiotherapy within 6 months prior to the first dose of study treatment if more than 30 Gy to the lung. - Symptomatic central nervous system (CNS) metastases, carcinomatous meningitis, or untreated spinal cord compression. - Clinically significant active cardiovascular disease or history of myocardial infarction within 6 months prior to planned start of selpercatinib or prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF) > 470 milliseconds. - Active uncontrolled systemic bacterial, viral, or fungal infection or serious ongoing intercurrent illness, such as hypertension or diabetes, despite optimal treatment. - Clinically significant active malabsorption syndrome or other condition likely to affect gastrointestinal absorption of the study drug. - Pregnancy or lactation. - Other malignancy unless nonmelanoma skin cancer, carcinoma in situ of the cervix or other in situ cancers or a malignancy diagnosed ≥2 years previously and not currently active. - Uncontrolled, disease related pericardial effusion or pleural effusion. - Requiring chronic treatment with steroids. Exclusion Criteria for Participants Receiving Pembrolizumab: - History of interstitial lung disease or interstitial pneumonitis. - Active autoimmune disease or any illness or treatment that could compromise the immune system.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Centro de Oncología e Investigación de Buenos Aires

Address:
City: Berazategui
Zip: B1884BBF
Country: Argentina

Facility:
Name: Fundacion CENIT para la Investigacion en Neurociencias

Address:
City: Caba
Zip: 1125
Country: Argentina

Facility:
Name: Clinica Viedma

Address:
City: Viedma
Zip: R8500ACE
Country: Argentina

Facility:
Name: Alexander Fleming

Address:
City: Ciudad de Buenos Aires
Zip: C1426ANZ
Country: Argentina

Facility:
Name: Clínica El Castaño

Address:
City: San Juan
Zip: 5400
Country: Argentina

Facility:
Name: Chris O'Brien Lifehouse

Address:
City: Camperdown
Zip: 2050
Country: Australia

Facility:
Name: Calvary Mater Newcastle

Address:
City: Waratah
Zip: 2298
Country: Australia

Facility:
Name: Westmead Hospital

Address:
City: Westmead
Zip: 2145
Country: Australia

Facility:
Name: Monash Health

Address:
City: Clayton
Zip: 3168
Country: Australia

Facility:
Name: Peter MacCallum Cancer Centre

Address:
City: Melbourne
Zip: 3000
Country: Australia

Facility:
Name: St Vincent's Hospital

Address:
City: Melbourne
Zip: 3065
Country: Australia

Facility:
Name: Peninsula Oncology Centre

Address:
City: Frankston
Zip: 3199
Country: Australia

Facility:
Name: UZ Brussel

Address:
City: Brussels
Zip: 1090
Country: Belgium

Facility:
Name: AZ Nikolaas

Address:
City: Sint Niklaas
Zip: B-9100
Country: Belgium

Facility:
Name: UZ Leuven

Address:
City: Leuven
Zip: 3000
Country: Belgium

Facility:
Name: AZ Delta

Address:
City: Roeselare
Zip: 8800
Country: Belgium

Facility:
Name: UZ Gent Hospital

Address:
City: Gent
Zip: 9000
Country: Belgium

Facility:
Name: AZ Sint-Maarten, Campus Leopoldstraat 2

Address:
City: Mechelen
Zip: 2800
Country: Belgium

Facility:
Name: CHU UCL Namur/Site Sainte Elisabeth

Address:
City: Namur
Zip: 5000
Country: Belgium

Facility:
Name: Núcleo de Oncologia da Bahia

Address:
City: Salvador
Zip: 40170-070
Country: Brazil

Facility:
Name: Hospital de Cancer de Londrina

Address:
City: Londrina
Zip: 86015-520
Country: Brazil

Facility:
Name: Hospital São Lucas da PUCRS

Address:
City: Porto Alegre
Zip: 90610-000
Country: Brazil

Facility:
Name: Grupo COI - Clínicas Oncológicas Integradas

Address:
City: Rio de Janeiro
Zip: 22775-001
Country: Brazil

Facility:
Name: Fundação Pio XII - Hospital de Câncer de Barretos

Address:
City: Barretos
Zip: 14784-400
Country: Brazil

Facility:
Name: Instituto D'Or de Pesquisa e Ensino (IDOR)

Address:
City: Sao Paulo
Zip: 04543-000
Country: Brazil

Facility:
Name: Instituto Nacional de Câncer - INCA

Address:
City: Rio de Janeiro
Zip: 20231-050
Country: Brazil

Facility:
Name: Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA

Address:
City: Rio de Janeiro
Zip: 22250-905
Country: Brazil

Facility:
Name: Hospital Sírio Libanês

Address:
City: Sao Paolo
Zip: 01308-060
Country: Brazil

Facility:
Name: Icesp - Instituto Do Câncer Do Estado de São Paulo

Address:
City: Sao Paulo
Zip: 01246000
Country: Brazil

Facility:
Name: Hospital Sírio Libanês

Address:
City: São Paulo
Zip: 01308-060
Country: Brazil

Facility:
Name: Cross Cancer Institute

Address:
City: Edmonton
Zip: T6G 1Z2
Country: Canada

Facility:
Name: Princess Margaret Cancer Centre

Address:
City: Toronto
Zip: M5G 2M9
Country: Canada

Facility:
Name: Beijing Cancer hospital

Address:
City: Beijing
Zip: 100142
Country: China

Facility:
Name: First affiliated Hospital of Sun Yat-Sen University

Address:
City: Guangzhou
Zip: 510080
Country: China

Facility:
Name: The First Affiated Hospital Of Guangzhou Medical Collage

Address:
City: Guangzhou
Zip: 510120
Country: China

Facility:
Name: Harbin Medical University Cancer Hospital

Address:
City: Harbin
Zip: 150081
Country: China

Facility:
Name: Wuhan Union Hospital

Address:
City: Wuhan
Zip: 430022
Country: China

Facility:
Name: Hunan Provincial People's Hospital

Address:
City: Changsha
Zip: 410005
Country: China

Facility:
Name: Hunan Cancer Hospital

Address:
City: Changsha
Zip: 410013
Country: China

Facility:
Name: Changzhou No.2 People's Hospital

Address:
City: Changzhou
Country: China

Facility:
Name: Jilin Cancer Hospital

Address:
City: Changchun
Country: China

Facility:
Name: Shanghai Pulmonary Hospital

Address:
City: Shanghai
Zip: 200433
Country: China

Facility:
Name: West China Hospital of Sichuan University

Address:
City: Cheng Du
Zip: 610041
Country: China

Facility:
Name: Xinjiang Medical University Cancer Hospital - Urumqi

Address:
City: Urumqi
Zip: 830000
Country: China

Facility:
Name: Zhejiang Cancer Hospital

Address:
City: Hangzhou
Country: China

Facility:
Name: First Affiliated Hosp of College of Med, Zhejiang University

Address:
City: Hangzhou
Zip: 310003
Country: China

Facility:
Name: Shanghai Chest Hospital

Address:
City: Shanghai
Zip: 200030
Country: China

Facility:
Name: Fakultni nemocnice Olomouc

Address:
City: Olomouc
Zip: 779 00
Country: Czechia

Facility:
Name: Nemocnice AGEL Ostrava - Vitkovice a.s.

Address:
City: Ostrava - Vitkovice
Zip: 70384
Country: Czechia

Facility:
Name: Fakultni nemocnice Bulovka

Address:
City: Praha 8
Zip: 180 81
Country: Czechia

Facility:
Name: Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Address:
City: Marseille
Zip: 13385
Country: France

Facility:
Name: Institut Régional du Cancer Montpellier

Address:
City: Montpellier Cedex 5
Zip: 34298
Country: France

Facility:
Name: Chu Grenoble Alpes

Address:
City: La Tronche
Zip: 38700
Country: France

Facility:
Name: Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne

Address:
City: Clermont-Ferrand
Zip: 63011
Country: France

Facility:
Name: Centre Leon Berard

Address:
City: Lyon
Zip: 69373
Country: France

Facility:
Name: Hopitaux Universitaires Paris Centre-Hopital Cochin

Address:
City: Paris
Zip: 75014
Country: France

Facility:
Name: Thoraxklinik-Heidelberg gGmbH

Address:
City: Heidelberg
Zip: 69126
Country: Germany

Facility:
Name: Asklepios Fachkliniken München-Gauting

Address:
City: Gauting
Zip: 82131
Country: Germany

Facility:
Name: Klinikverbund Kempten-Oberallgäu

Address:
City: Immenstadt
Zip: 87509
Country: Germany

Facility:
Name: Franziskus-Hospital Harderberg

Address:
City: Georgsmarienhütte
Zip: 49124
Country: Germany

Facility:
Name: Universitätsmedizin Göttingen

Address:
City: Göttingen
Zip: 37075
Country: Germany

Facility:
Name: University Hospital of Cologne

Address:
City: Köln
Zip: 50937
Country: Germany

Facility:
Name: LungenClinic Grosshansdorf

Address:
City: Grosshansdorf
Zip: 22927
Country: Germany

Facility:
Name: Charite Universitätsmedizin Berlin Campus Benjamin Franklin

Address:
City: Berlin
Zip: 12203
Country: Germany

Facility:
Name: Sotiria Thoracic Diseases Hospital of Athens

Address:
City: Athens
Zip: 115 27
Country: Greece

Facility:
Name: University General Hospital of Heraklion

Address:
City: Heraklion
Zip: 711 10
Country: Greece

Facility:
Name: European Interbalkan Medical Center

Address:
City: Thessaloniki
Zip: 570 01
Country: Greece

Facility:
Name: G. Papanikolaou General Hospital

Address:
City: Thessaloniki
Zip: 570 10
Country: Greece

Facility:
Name: Hong Kong United Oncology Centre

Address:
City: Jordan
Zip: 999077
Country: Hong Kong

Facility:
Name: Prince of Wales Hospital

Address:
City: Shatin
Zip: 852
Country: Hong Kong

Facility:
Name: Soroka Medical Center

Address:
City: Beer-Sheva
Zip: 8400000
Country: Israel

Facility:
Name: Shaare Zedek Medical Center

Address:
City: Jerusalem
Zip: 9103102
Country: Israel

Facility:
Name: Hadassah Medical Center

Address:
City: Jerusalem
Zip: 9112001
Country: Israel

Facility:
Name: Sheba Medical Center

Address:
City: Ramat Gan
Zip: 5262100
Country: Israel

Facility:
Name: Rambam Health Care Campus

Address:
City: Haifa
Zip: 3109601
Country: Israel

Facility:
Name: Istituto Nazionale Tumori IRCCS Fondazione Pascale

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: Ospedale Santa Maria delle Croci

Address:
City: Ravenna
Zip: 48121
Country: Italy

Facility:
Name: Cro-Irccs

Address:
City: Aviano
Zip: 33081
Country: Italy

Facility:
Name: Azienda Ospedaliera San Camillo Forlanini

Address:
City: Roma
Zip: 00152
Country: Italy

Facility:
Name: Fondazione Policlinico Universitario Agostino Gemelli

Address:
City: Roma
Zip: 00168
Country: Italy

Facility:
Name: Ospedale San Gerardo-ASST Monza

Address:
City: Monza
Zip: 20900
Country: Italy

Facility:
Name: ASST Grande Ospedale Metropolitano Niguarda

Address:
City: Milan
Zip: 20162
Country: Italy

Facility:
Name: Humanitas

Address:
City: Rozzano
Zip: 20089
Country: Italy

Facility:
Name: Azienda Sanitaria Ospedaliera S Luigi Gonzaga

Address:
City: Orbassano
Zip: 10043
Country: Italy

Facility:
Name: Azienda Ospedaliera San Giuseppe Moscati

Address:
City: Avellino
Zip: 83100
Country: Italy

Facility:
Name: IRCCS - AOU di Bologna

Address:
City: Bologna
Zip: 40138
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria Pisana

Address:
City: Pisa
Zip: 56126
Country: Italy

Facility:
Name: Istituto Nazionale Tumori Regina Elena

Address:
City: Roma
Zip: 00144
Country: Italy

Facility:
Name: National Cancer Center Hospital East

Address:
City: Kashiwa
Zip: 277-8577
Country: Japan

Facility:
Name: National Hospital Organization Hokkaido Cancer Center

Address:
City: Sapporo
Zip: 003-0804
Country: Japan

Facility:
Name: Kanazawa University Hospital

Address:
City: Kanazawa
Zip: 920-8641
Country: Japan

Facility:
Name: Kanagawa cancer center

Address:
City: Yokohama
Zip: 241-8515
Country: Japan

Facility:
Name: Kindai University Hospital- Osakasayama Campus

Address:
City: Osaka Sayama-shi
Zip: 589 8511
Country: Japan

Facility:
Name: Tominaga Hospital

Address:
City: Nagaizumi
Zip: 411-8777
Country: Japan

Facility:
Name: National Cancer Center Hospital

Address:
City: Chuo-ku
Zip: 104-0045
Country: Japan

Facility:
Name: Japanese Foundation for Cancer Research

Address:
City: Koto
Zip: 135-8550
Country: Japan

Facility:
Name: Tottori University Hospital

Address:
City: Yonago
Zip: 683-8504
Country: Japan

Facility:
Name: Okayama University Hospital

Address:
City: Okayama
Zip: 700-8558
Country: Japan

Facility:
Name: Osaka International Cancer Institute

Address:
City: Osaka
Zip: 541-8567
Country: Japan

Facility:
Name: National Cancer Center

Address:
City: Goyang-si
Zip: 10408
Country: Korea, Republic of

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam-si
Zip: 13620
Country: Korea, Republic of

Facility:
Name: Gachon University Gil Medical Center

Address:
City: Incheon
Zip: 21565
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Gyeongsang National University Hospital

Address:
City: Jin-ju-si
Zip: 52727
Country: Korea, Republic of

Facility:
Name: Seoul National University Hospital

Address:
City: Seoul
Zip: 03080
Country: Korea, Republic of

Facility:
Name: Boramae Medical Center

Address:
City: Dongjak-gu
Zip: 07061
Country: Korea, Republic of

Facility:
Name: Konyang University Hospital

Address:
City: Daejon
Zip: 35365
Country: Korea, Republic of

Facility:
Name: Samsung Medical Center

Address:
City: Seoul
Zip: 06351
Country: Korea, Republic of

Facility:
Name: Health Pharma Professional Research S.A. de C.V:

Address:
City: Mexico City
Zip: 03100
Country: Mexico

Facility:
Name: Actualidad Basada en la Investigación del Cáncer

Address:
City: Guadalajara
Zip: 44680
Country: Mexico

Facility:
Name: Oncologico Potosino, S.C.

Address:
City: San Luis Potosí
Zip: 78209
Country: Mexico

Facility:
Name: Ziekenhuis St. Jansdal

Address:
City: Harderwijk
Zip: 3844 DG
Country: Netherlands

Facility:
Name: Jeroen Bosch ziekenhuis

Address:
City: Den Bosch
Zip: 5223 GZ
Country: Netherlands

Facility:
Name: Erasmus Medisch Centrum

Address:
City: Rotterdam
Zip: 3015 CE
Country: Netherlands

Facility:
Name: Amsterdam UMC, locatie VUmc

Address:
City: Amsterdam
Zip: 1081 HV
Country: Netherlands

Facility:
Name: Uniwersyteckie Centrum Kliniczne

Address:
City: Gdansk
Zip: 80-952
Country: Poland

Facility:
Name: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Institutul Oncologic

Address:
City: Bucharest
Zip: 22328
Country: Romania

Facility:
Name: Gral Medical Diagnostic Center

Address:
City: Bucuresti
Zip: 031422
Country: Romania

Facility:
Name: Constanta County Emergency Clinical Hospital Sf.Ap.Andrei

Address:
City: Constanta
Zip: 900591
Country: Romania

Facility:
Name: Cabinet Medical Oncomed

Address:
City: Timișoara
Zip: 300239
Country: Romania

Facility:
Name: Spitalul Universitar de Urgență București

Address:
City: Bucuresti
Zip: 050098
Country: Romania

Facility:
Name: Institutul Oncologic

Address:
City: Cluj-Napoca
Zip: 400015
Country: Romania

Facility:
Name: Spitalul Județean Sfântul Ioan cel Nou Suceava

Address:
City: Suceava
Zip: 720237
Country: Romania

Facility:
Name: GBUZ Republican Clinical Oncological Dispensary

Address:
City: Ufa
Zip: 450054
Country: Russian Federation

Facility:
Name: Kaluga Regional Clinical Oncology Center

Address:
City: Kaluga
Zip: 248007
Country: Russian Federation

Facility:
Name: Murmansk Regional Clinical Hospital P.A. Bayandina

Address:
City: Murmansk
Zip: 183047
Country: Russian Federation

Facility:
Name: Samara Regional Clinical Oncology Center

Address:
City: Samara
Zip: 443031
Country: Russian Federation

Facility:
Name: Scientific research institution of oncology named after N.N. Petrov

Address:
City: Saint Petersburg
Zip: 197758
Country: Russian Federation

Facility:
Name: Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (oncological) named afte -T

Address:
City: St. Petersburg
Zip: 197758
Country: Russian Federation

Facility:
Name: Arkhangelsk Clinical Oncological Dispensary

Address:
City: Arkhangelsk
Zip: 163045
Country: Russian Federation

Facility:
Name: Republican Clinical Oncology Dispensary

Address:
City: Kazan
Zip: 420029
Country: Russian Federation

Facility:
Name: First Moscow State Medical University I.M. Sechenov

Address:
City: Moscow
Zip: 119991
Country: Russian Federation

Facility:
Name: Hadassah Medical

Address:
City: Moscow
Zip: 121205
Country: Russian Federation

Facility:
Name: Tan Tock Seng Hospital

Address:
City: Singapore
Zip: 308433
Country: Singapore

Facility:
Name: Hospital Fundacion Son Llatzer

Address:
City: Palma de Mallorca
Zip: 07198
Country: Spain

Facility:
Name: Institut Català d'Oncologia (ICO) - Badalona

Address:
City: Badalona
Zip: 08916
Country: Spain

Facility:
Name: CHUS - Hospital Clinico Universitario

Address:
City: Santiago de Compostela
Zip: 15706
Country: Spain

Facility:
Name: Hospital Insular de Gran Canaria

Address:
City: Las palmas de gran canaria
Zip: 35016
Country: Spain

Facility:
Name: Hospital Universitario Puerta de Hierro Majadahonda

Address:
City: Majadahonda
Zip: 28222
Country: Spain

Facility:
Name: Clinica Universitaria De Navarra

Address:
City: Pamplona
Zip: 31008
Country: Spain

Facility:
Name: Hospital General Universitario de Alicante

Address:
City: Alicante
Zip: 03010
Country: Spain

Facility:
Name: Parc de Salut Mar - Hospital del Mar

Address:
City: Barcelona
Zip: 08003
Country: Spain

Facility:
Name: Hospital Universitari Dexeus

Address:
City: Barcelona
Zip: 08028
Country: Spain

Facility:
Name: Instituto Catalan de Oncologia - Hospital Duran i Reynals

Address:
City: Barcelona
Zip: 08908
Country: Spain

Facility:
Name: Hospital de la Santa Creu i Sant Pau

Address:
City: Barcelona
Zip: 8041
Country: Spain

Facility:
Name: Complejo Hospitalario de Jaén

Address:
City: Jaén
Zip: 23007
Country: Spain

Facility:
Name: Clinica Universidad de Navarra

Address:
City: Madrid
Zip: 28027
Country: Spain

Facility:
Name: Hospital Universitario Ramón y Cajal

Address:
City: Madrid
Zip: 28034
Country: Spain

Facility:
Name: Hospital Clinico San Carlos

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario 12 de Octubre

Address:
City: Madrid
Zip: 28041
Country: Spain

Facility:
Name: Hospital Universitario La Paz

Address:
City: Madrid
Zip: 28046
Country: Spain

Facility:
Name: Hospital Regional Universitario

Address:
City: Malaga
Zip: 29011
Country: Spain

Facility:
Name: Complejo Hospitalario de Navarra

Address:
City: Pamplona
Zip: 31009
Country: Spain

Facility:
Name: Hospital Universitario Virgen Macarena

Address:
City: Sevilla
Zip: 41009
Country: Spain

Facility:
Name: Hospital Universitario Virgen Del Rocio

Address:
City: Sevilla
Zip: 41013
Country: Spain

Facility:
Name: Hospital Clínico Universitario de Valencia

Address:
City: Valencia
Zip: 46010
Country: Spain

Facility:
Name: Hospital Universitari i Politecnic La Fe

Address:
City: Valencia
Zip: 46026
Country: Spain

Facility:
Name: Changhua Christian Hospital

Address:
City: Changhua County
Zip: 50006
Country: Taiwan

Facility:
Name: Buddhist Dalin Tzu Chi General Hospital

Address:
City: Dalin Town
Zip: 622
Country: Taiwan

Facility:
Name: Chang Gung Memorial Hospital - Linkou

Address:
City: Guei Shan Township
Zip: 333
Country: Taiwan

Facility:
Name: E-Da hospital

Address:
City: Kaohsiung
Zip: 82445
Country: Taiwan

Facility:
Name: Chang Gung Memorial Hospital at Kaohsiung

Address:
City: Kaohsiung
Zip: 83301
Country: Taiwan

Facility:
Name: Tri-Service General Hospital

Address:
City: Neihu Taipei
Zip: 114
Country: Taiwan

Facility:
Name: Taipei Medical University Shuang Ho Hospital

Address:
City: New Taipei
Zip: 235
Country: Taiwan

Facility:
Name: Chung Shan Medical University Hospital

Address:
City: Taichung
Zip: 402
Country: Taiwan

Facility:
Name: China Medical University Hospital

Address:
City: Taichung
Zip: 40447
Country: Taiwan

Facility:
Name: Taichung Veterans General Hospital

Address:
City: Taichung
Zip: 407
Country: Taiwan

Facility:
Name: Chi Mei Hospital - Liouying Branch

Address:
City: Tainan City
Zip: 73657
Country: Taiwan

Facility:
Name: National Cheng-Kung Uni. Hosp.

Address:
City: Tainan
Zip: 704
Country: Taiwan

Facility:
Name: National Taiwan University Hospital

Address:
City: Taipei City
Zip: 10048
Country: Taiwan

Facility:
Name: Taipei Veterans General Hospital

Address:
City: Taipei
Zip: 11217
Country: Taiwan

Facility:
Name: Ege Universitesi Hastanesi

Address:
City: Bornova
Zip: 35100
Country: Turkey

Facility:
Name: Baskent University Dr. Turgut Noyan Research and Training Center

Address:
City: Adana
Zip: 1250
Country: Turkey

Facility:
Name: Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi

Address:
City: Ankara
Zip: 6200
Country: Turkey

Facility:
Name: Hacettepe University Faculty of Medicine

Address:
City: Ankara
Zip: 6230
Country: Turkey

Facility:
Name: Memorial Antalya Hastanesi

Address:
City: Antalya
Zip: 7090
Country: Turkey

Facility:
Name: Dicle Üniversitesi

Address:
City: Diyarbakir
Zip: 21100
Country: Turkey

Facility:
Name: Trakya University

Address:
City: Edirne
Zip: 22030
Country: Turkey

Facility:
Name: Istanbul Medeniyet University

Address:
City: Istanbul
Zip: 34722
Country: Turkey

Facility:
Name: zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi

Address:
City: Izmir
Zip: 35360
Country: Turkey

Facility:
Name: Izmir Medical Park Hospital

Address:
City: Izmir
Zip: 9035575
Country: Turkey

Facility:
Name: Inonu Universitesi Turgut Ozal Tıp Merkezi

Address:
City: Malatya
Zip: 44280
Country: Turkey

Facility:
Name: Acıbadem Maslak Hastanesi

Address:
City: Sarıyer
Zip: 34457
Country: Turkey

Facility:
Name: Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council, "Dnipro State Medical University"

Address:
City: Dnipro
Zip: 49102
Country: Ukraine

Facility:
Name: CNPE "Regional Center of Oncology"

Address:
City: Kharkiv
Zip: 61070
Country: Ukraine

Facility:
Name: Odessa Regional Oncology Center

Address:
City: Odesa
Zip: 65055
Country: Ukraine

Facility:
Name: Sumy regional clinical oncological dispensary

Address:
City: Sumy
Zip: 40022
Country: Ukraine

Facility:
Name: Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council"

Address:
City: Vinnytsia
Zip: 21029
Country: Ukraine

Facility:
Name: Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council

Address:
City: Lutsk
Zip: 43018
Country: Ukraine

Facility:
Name: "Oncolife" LLC

Address:
City: Zaporizhya
Zip: 69059
Country: Ukraine

Facility:
Name: Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center"

Address:
City: Chernivtsi
Zip: 58013
Country: Ukraine

Facility:
Name: Medical Center "Mriya Med-Service", LLC

Address:
City: Kryvyi Rig
Zip: 50000
Country: Ukraine

Facility:
Name: Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City Counci -T

Address:
City: Kyiv
Zip: 03115
Country: Ukraine

Facility:
Name: Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council

Address:
City: Odesa
Zip: 65025
Country: Ukraine

Facility:
Name: City Hospital, Nottingham University Hospitals

Address:
City: Nottingham
Zip: NG5 1PB
Country: United Kingdom

Start date: February 17, 2020

Completion date: June 18, 2026

Lead sponsor:
Agency: Loxo Oncology, Inc.
Agency class: Industry

Collaborator:
Agency: Eli Lilly and Company
Agency class: Industry

Source: Eli Lilly and Company

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT04194944
https://trials.lilly.com/en-US/trial/230195