A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)

Trial Title: A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)

NCT ID: NCT04513925

Condition: Non-small Cell Lung Cancer (NSCLC)

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Atezolizumab
Durvalumab

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Atezolizumab
Description: Atezolizumab 1680 mg every 4 weeks (Q4W) will be administered IV on Day 1 of each 28-day cycle.
Arm group label: Atezolizumab + Tiragolumab

Other name: Tecentriq; RO5541267

Intervention type: Drug
Intervention name: Tiragolumab
Description: Tiragolumab 840 mg Q4W will be administered IV on Day 1 of each 28-day cycle.
Arm group label: Atezolizumab + Tiragolumab

Other name: MTIG7192A; RO7092284

Intervention type: Drug
Intervention name: Durvalumab
Description: Durvalumab will be administered based on weight at 10 mg/kg IV every 2 weeks (Q2W) on Days 1 and 15 of each 28-day cycle, or will be administered at a fixed dose of 1500 mg IV every 4 weeks (Q4W) (for participants whose weight >/= 30 kg) on Day 1 of each 28-day cycle.
Arm group label: Durvalumab

Summary: The purpose of this study is to evaluate the efficacy and safety of atezolizumab in combination with tiragolumab compared with durvalumab in participants with locally advanced, unresectable Stage III non-small cell lung cancer (NSCLC) who have received at least two cycles of concurrent platinum-based chemoradiotherapy (CRT) and have not had radiographic disease progression.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 - Histologically or cytologically documented NSCLC with locally advanced, unresectable Stage III NSCLC of either squamous or non-squamous histology - Whole-body Positron Emission Tomography-Computed Tomography (PET-CT) scan, performed prior and within 42 days of the first dose of concurrent chemoradiotherapy (cCRT) - At least two prior cycles of platinum-based chemotherapy administered concurrently with radiotherapy (RT), which must be completed within 1 to 42 days prior to randomization in the study (one cycle of cCRT is defined as 21 or 28 days) - The radiotherapy (RT) component in the cCRT must have been at a total dose of radiation of 60 (±10 percent [%]) gray (Gy) (54 Gy to 66 Gy) administered by intensity modulated RT (preferred) or 3D-conforming technique - No progression during or following concurrent platinum-based CRT - A known PD-L1 result - Life expectancy >/= 12 weeks - Adequate hematologic and end-organ function - Female participants must be willing to avoid pregnancy for 90 days after the final dose of tiragolumab and 5 months after the final dose of atezolizumab, or for 3 months after the final dose of durvalumab - Male participants must remain abstinent or use a condom during the treatment period and for 90 days after the final dose of tiragolumab - Male participants must not donate sperm during the treatment period and for 90 days after the final dose of tiragolumab Exclusion Criteria: - Any history of prior NSCLC and/or any history of prior treatment for NSCLC (participants must be newly diagnosed with unresectable Stage III disease) - NSCLC known to have a mutation in the epidermal growth factor receptor (EGFR) gene or an anaplastic lymphoma kinase (ALK) fusion oncogene - Any evidence of Stage IV disease - Treatment with sequential CRT for locally advanced NSCLC - Participants with locally advanced NSCLC who have progressed during or after the definitive cCRT prior to randomization - Any Grade >2 unresolved toxicity from previous CRT - Grade >= 2 pneumonitis from prior CRT - Active or history of autoimmune disease or immune deficiency - History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis or evidence of active pneumonitis - History of malignancy other than NSCLC within 5 years prior to screening with the exception of malignancies with a negligible risk of metastasis or death - Prior allogeneic stem cell or solid organ transplantation - Active Epstein-Barr virus (EBV) infection or known or suspected chronic active EBV infection at screening - Treatment with investigational therapy within 28 days prior to initiation of study treatment - Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including anti-cytotoxic T lymphocyte-associated protein 4, anti-T-cell immunoreceptor with Ig and ITIM domains (anti-TIGIT), anti-PD-1 and anti-PD-L1 - Any prior Grade >/= 3 immune-mediated adverse event or any unresolved Grade > 1 immune-mediated adverse event while receiving any previous immunotherapy agent other than immune checkpoint blockade agents - Treatment with systemic immunosuppressive medication - Women who are pregnant, or breastfeeding

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Banner MD Anderson Cancer Center

Address:
City: Gilbert
Zip: 85234
Country: United States

Facility:
Name: Arizona Clinical Research Center, Inc

Address:
City: Tucson
Zip: 85715
Country: United States

Facility:
Name: Genesis Cancer and Blood Institute

Address:
City: Hot Springs
Zip: 71913
Country: United States

Facility:
Name: Stanford University

Address:
City: Palo Alto
Zip: 94305
Country: United States

Facility:
Name: Florida Cancer Specialists; Department of Oncology

Address:
City: Fort Myers
Zip: 33901-8101
Country: United States

Facility:
Name: Woodlands Medical Specialists, P.A.

Address:
City: Pensacola
Zip: 32503
Country: United States

Facility:
Name: Cancer Care Centers of Brevard

Address:
City: Rockledge
Zip: 32955
Country: United States

Facility:
Name: Florida Cancer Specialist, North Region

Address:
City: Saint Petersburg
Zip: 33705
Country: United States

Facility:
Name: Northwest Georgia Oncology Centers PC - Marietta

Address:
City: Marietta
Zip: 30060
Country: United States

Facility:
Name: Illinois Cancer Care

Address:
City: Peoria
Zip: 61615
Country: United States

Facility:
Name: New England Cancer Specialists

Address:
City: Brunswick
Zip: 04011
Country: United States

Facility:
Name: Southcoast Health System

Address:
City: Fairhaven
Zip: 02719
Country: United States

Facility:
Name: Minnesota Oncology Hematology

Address:
City: Saint Paul
Zip: 55102
Country: United States

Facility:
Name: HCA Midwest Health

Address:
City: Kansas City
Zip: 64132
Country: United States

Facility:
Name: Cox Health Systems

Address:
City: Springfield
Zip: 65807
Country: United States

Facility:
Name: Optum Health Care

Address:
City: Las Vegas
Zip: 89102
Country: United States

Facility:
Name: Comprehensive Cancer Centers of Nevada

Address:
City: Las Vegas
Zip: 89128
Country: United States

Facility:
Name: Titan Health Partners LLC, d/b/a Astera Cancer Care

Address:
City: East Brunswick
Zip: 08816
Country: United States

Facility:
Name: San Juan Oncology Associates

Address:
City: Farmington
Zip: 87401
Country: United States

Facility:
Name: New York Oncology Hematology,P.C.-Albany

Address:
City: Albany
Zip: 12208
Country: United States

Facility:
Name: Montefiore Medical Center

Address:
City: Bronx
Zip: 10467
Country: United States

Facility:
Name: Mount Sinai Medical Center

Address:
City: New York
Zip: 10029
Country: United States

Facility:
Name: Prisma Health ? Upstate

Address:
City: Greenville
Zip: 29615
Country: United States

Facility:
Name: Tennessee Oncology Chattanooga

Address:
City: Chattanooga
Zip: 37404-3230
Country: United States

Facility:
Name: Sarah Cannon Research Institute / Tennessee Oncology

Address:
City: Nashville
Zip: 37203
Country: United States

Facility:
Name: Virginia Cancer Specialists

Address:
City: Fairfax
Zip: 22031
Country: United States

Facility:
Name: Virginia Oncology Associates

Address:
City: Norfolk
Zip: 23502
Country: United States

Facility:
Name: Cemic; Oncologia Clinica

Address:
City: Buenos Aires
Zip: C1431FWN
Country: Argentina

Facility:
Name: Hospital Britanico de Buenos Aires

Address:
City: Ciudad Autonoma Buenos Aires
Zip: C1284AEB
Country: Argentina

Facility:
Name: Clinica Universitaria Reina Fabiola

Address:
City: Cordoba
Zip: X5004FHP
Country: Argentina

Facility:
Name: Sanatorio Parque S.A.

Address:
City: Rosario
Zip: S2000QGB
Country: Argentina

Facility:
Name: Blacktown Hospital

Address:
City: Blacktown
Zip: 2148
Country: Australia

Facility:
Name: Macarthur Cancer Therapy Centre

Address:
City: Campbelltown
Zip: 2560
Country: Australia

Facility:
Name: St George Hospital; Cancer Care Centre

Address:
City: Kogarah
Zip: 2217
Country: Australia

Facility:
Name: Princess Alexandra Hospital

Address:
City: Woolloongabba
Zip: 4102
Country: Australia

Facility:
Name: Flinders Medical Centre

Address:
City: Bedford Park
Zip: 5042
Country: Australia

Facility:
Name: Fiona Stanley Hospital; FSH Cancer Centre Clinical Trials Unit

Address:
City: Bull Creek
Zip: 6149
Country: Australia

Facility:
Name: Monash Health Translational Precinct; Clinical Trials Centre, Level 3

Address:
City: Victoria
Zip: 3168
Country: Australia

Facility:
Name: Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie

Address:
City: Innsbruck
Zip: 6020
Country: Austria

Facility:
Name: Kepler Universitätskliniken GmbH - Med Campus III; Abt. für Lungenkrankheiten

Address:
City: Linz
Zip: 4020
Country: Austria

Facility:
Name: Klinik Penzing; Abteilung für Atemwegs- und Lungenkrankheiten

Address:
City: Wien
Zip: 1140
Country: Austria

Facility:
Name: GHdC Site Notre Dame

Address:
City: Charleroi
Zip: 6000
Country: Belgium

Facility:
Name: AZ Maria Middelares

Address:
City: Gent
Zip: 9000
Country: Belgium

Facility:
Name: Jessa Zkh (Campus Virga Jesse)

Address:
City: Hasselt
Zip: 3500
Country: Belgium

Facility:
Name: Hospital Sao Rafael - HSR

Address:
City: Salvador
Zip: 41253-190
Country: Brazil

Facility:
Name: Crio - Centro Regional Integrado de Oncologia

Address:
City: Fortaleza
Zip: 60336-232
Country: Brazil

Facility:
Name: Centro Integrado de Oncologia de Curitiba

Address:
City: Curitiba
Zip: 80810-050
Country: Brazil

Facility:
Name: Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Address:
City: Ijui
Zip: 98700-000
Country: Brazil

Facility:
Name: Hospital Sao Lucas - PUCRS

Address:
City: Porto Alegre
Zip: 90610-000
Country: Brazil

Facility:
Name: Hospital de Cancer de Barretos

Address:
City: Barretos
Zip: 14784-400
Country: Brazil

Facility:
Name: Hospital de Base de Sao Jose do Rio Preto

Address:
City: Sao Jose do Rio Preto
Zip: 15090-000
Country: Brazil

Facility:
Name: Instituto do Cancer do Estado de Sao Paulo - ICESP

Address:
City: Sao Paulo
Zip: 01246-000
Country: Brazil

Facility:
Name: BC Cancer ? Abbotsford

Address:
City: Abbotsford
Zip: V2S 0C2
Country: Canada

Facility:
Name: BC Cancer - Victoria

Address:
City: Victoria
Zip: V8R 6V5
Country: Canada

Facility:
Name: Royal Victoria Regional Health Centre; c/o Oncology Clinical Trials

Address:
City: Barrie
Zip: L4M 6M2
Country: Canada

Facility:
Name: William Osler Health System Brampton Civic Hospital

Address:
City: Brampton
Zip: L6R 3J7
Country: Canada

Facility:
Name: Ottawa Hospital Research Institute

Address:
City: Ottawa
Zip: K1Y 4E9
Country: Canada

Facility:
Name: Beijing Cancer Center; Renal Cancer And Melanoma Department.

Address:
City: Beijing City
Zip: 100142
Country: China

Facility:
Name: Beijing Chest Hospital; Oncology Department

Address:
City: Beijing
Zip: 101149
Country: China

Facility:
Name: Jilin Cancer Hospital

Address:
City: Changchun
Zip: 132013
Country: China

Facility:
Name: Xiangya Hospital Central South University

Address:
City: Changsha City
Zip: 410008
Country: China

Facility:
Name: Changzhou Cancer hospital

Address:
City: Changzhou
Zip: 213000
Country: China

Facility:
Name: Sichuan Provincial Cancer Hospital

Address:
City: Chengdu
Zip: 610041
Country: China

Facility:
Name: Chongqing Cancer Hospital

Address:
City: Chongqing
Zip: 400030
Country: China

Facility:
Name: Fujian Medical University Union Hospital

Address:
City: Fuzhou City
Zip: 350001
Country: China

Facility:
Name: Fujian Provincial Cancer Hospital

Address:
City: Fuzhou City
Zip: 350014
Country: China

Facility:
Name: Cancer Center, Sun Yat-sen University of Medical Sciences; Department of Medical Oncology

Address:
City: Guangzhou City
Zip: 510060
Country: China

Facility:
Name: Hangzhou Cancer Hospital

Address:
City: Hangzhou City
Zip: 310002
Country: China

Facility:
Name: Sir Run Run Shaw Hospital Zhejiang University

Address:
City: Hangzhou City
Zip: 310016
Country: China

Facility:
Name: Shandong Cancer Hospital

Address:
City: Jinan
Zip: 250117
Country: China

Facility:
Name: Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University)

Address:
City: Nanjing City
Zip: 210029
Country: China

Facility:
Name: Zhongda Hospital Affiliated to Southeast University

Address:
City: Nanjing
Zip: 210009
Country: China

Facility:
Name: The affiliated hospital of Qingdao university

Address:
City: Qingdao City
Zip: 266042
Country: China

Facility:
Name: Shanghai Chest Hospital

Address:
City: Shanghai
Zip: 200000
Country: China

Facility:
Name: Shanghai Pulmonary Hospital

Address:
City: Shanghai
Zip: 200433
Country: China

Facility:
Name: Cancer Hospital of Shantou University Medical College

Address:
City: Shantou
Zip: 515041
Country: China

Facility:
Name: Shanxi Provincial Cancer Hospital

Address:
City: Taiyuan
Zip: 030013
Country: China

Facility:
Name: Tianjin Cancer Hospital

Address:
City: Tianjin
Zip: 300060
Country: China

Facility:
Name: The 2nd School of Medicine, WMU

Address:
City: Wenzhou City
Zip: 325000
Country: China

Facility:
Name: Union Hospital Tongji Medical College Huazhong University of Science and Technology

Address:
City: Wuhan City
Zip: 430023
Country: China

Facility:
Name: Hubei Cancer Hospital

Address:
City: Wuhan
Zip: 430079
Country: China

Facility:
Name: The First Affiliated Hospital of Xiamen University

Address:
City: Xiamen
Zip: 361003
Country: China

Facility:
Name: The Affiliated Hospital of Xuzhou Medical College

Address:
City: Xuzhou
Zip: 221000
Country: China

Facility:
Name: Henan Cancer Hospital

Address:
City: Zhengzhou
Zip: 450008
Country: China

Facility:
Name: CHU Angers

Address:
City: Angers
Zip: 49933
Country: France

Facility:
Name: CENTRE FRANCOIS BACLESSE; Oncologie- Pneumologie

Address:
City: Caen
Zip: 14000
Country: France

Facility:
Name: Hopital Nord AP-HM

Address:
City: Marseille
Zip: 13015
Country: France

Facility:
Name: Clinique Clémentville

Address:
City: Montpellier
Zip: 34070
Country: France

Facility:
Name: Hopital Robert Schuman; Pneumologie

Address:
City: Vantoux
Zip: 57070
Country: France

Facility:
Name: Institut Gustave Roussy; Pathologie Thoracique

Address:
City: Villejuif cedex
Zip: 94805
Country: France

Facility:
Name: Klinikum Braunschweig; Medizinische Klinik III; Klinik für Hämatologie und Onkologie

Address:
City: Braunschweig
Zip: 38114
Country: Germany

Facility:
Name: Universitaetsmedizin Goettingen; Abteilung Haematologie und Onkologie

Address:
City: Göttingen
Zip: 37075
Country: Germany

Facility:
Name: Thoraxklinik Heidelberg gGmbH

Address:
City: Heidelberg
Zip: 69126
Country: Germany

Facility:
Name: Klinikum Koeln-Merheim; Lungenklinik

Address:
City: Köln
Zip: 51109
Country: Germany

Facility:
Name: Klinikum Bogenhausen; Klinik für Pneumologie und Pneumologische Onkologie

Address:
City: München
Zip: 81925
Country: Germany

Facility:
Name: Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie

Address:
City: Regensburg
Zip: 93053
Country: Germany

Facility:
Name: General Hospital "G.Papanikolaou"; Pulmonogy Clinic

Address:
City: Asvestochori
Zip: 570 10
Country: Greece

Facility:
Name: Sotiria Hospital

Address:
City: Athens
Zip: 104 31
Country: Greece

Facility:
Name: Univ General Hosp Heraklion; Medical Oncology

Address:
City: Heraklion
Zip: 711 10
Country: Greece

Facility:
Name: Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.

Address:
City: Kifisia
Zip: 145 64
Country: Greece

Facility:
Name: Pamela Youde Nethersole Eastern Hospital; Clinical Oncology

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Princess Margaret Hospital, Oncology; Department of Oncology

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Queen Elizabeth Hospital; Clinical Oncology

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Tuen Mun Hospital; Clinical Onc

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Queen Mary Hospital

Address:
City: Pokfulam
Country: Hong Kong

Facility:
Name: Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet

Address:
City: Pécs
Zip: 7623
Country: Hungary

Facility:
Name: Szent Borbala Korhaz

Address:
City: Tatabánya
Zip: 2800
Country: Hungary

Facility:
Name: Tudogyogyintezet Torokbalint

Address:
City: Torokbalint
Zip: 2045
Country: Hungary

Facility:
Name: Soroka Medical Center; Oncology Dept

Address:
City: Beer Sheva
Zip: 8410100
Country: Israel

Facility:
Name: Rambam Medical Center; Oncology

Address:
City: Haifa
Zip: 3109601
Country: Israel

Facility:
Name: Shaare Zedek Medical Center; Oncology Dept

Address:
City: Jerusalem
Zip: 9103102
Country: Israel

Facility:
Name: Rabin Medical Center; Oncology Dept

Address:
City: Petah Tikva
Zip: 4910000
Country: Israel

Facility:
Name: Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica

Address:
City: Meldola
Zip: 47014
Country: Italy

Facility:
Name: Azienda Ospedaliero Universitaria di Parma

Address:
City: Parma
Zip: 43126
Country: Italy

Facility:
Name: Policlinico Universitario Campus Biomedico; U.O.C. di Radioterapia Oncologica

Address:
City: Roma
Zip: 00128
Country: Italy

Facility:
Name: IRCCS Istituto Regina Elena (IFO); Oncologia Medica B

Address:
City: Roma
Zip: 00144
Country: Italy

Facility:
Name: IRCCS AOU San Martino - IST

Address:
City: Genova
Zip: 16132
Country: Italy

Facility:
Name: A.O. Spedali Civili Di Brescia-P.O. Spedali Civili; U.O. Radioterapia

Address:
City: Brescia
Zip: 25123
Country: Italy

Facility:
Name: Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)

Address:
City: Milano
Country: Italy

Facility:
Name: Fondazione IRCCS Policlinico San Matteo

Address:
City: Pavia
Zip: 27100
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello; Dipartimento Cardio Toraco Vascolare

Address:
City: Pisa
Zip: 56124
Country: Italy

Facility:
Name: Azienda ULSS 8 Berica; Oncologia Medica - Ospedlae di Vicenza

Address:
City: Vicenza
Zip: 36100
Country: Italy

Facility:
Name: Aichi Cancer Center

Address:
City: Aichi
Zip: 464-8681
Country: Japan

Facility:
Name: National Cancer Center East

Address:
City: Chiba
Zip: 277-8577
Country: Japan

Facility:
Name: National Hospital Organization Himeji Medical Center

Address:
City: Hyogo
Zip: 670-8520
Country: Japan

Facility:
Name: Kitasato University Hospital

Address:
City: Kanagawa
Zip: 252-0375
Country: Japan

Facility:
Name: Kyoto University Hospital

Address:
City: Kyoto
Zip: 606-8507
Country: Japan

Facility:
Name: Sendai Kousei Hospital

Address:
City: Miyagi
Zip: 981-0914
Country: Japan

Facility:
Name: Niigata Cancer Center Hospital

Address:
City: Niigata
Zip: 951-8566
Country: Japan

Facility:
Name: Kindai University Hospital

Address:
City: Osaka
Zip: 589-8511
Country: Japan

Facility:
Name: Saitama Cancer Center

Address:
City: Saitama
Zip: 362-0806
Country: Japan

Facility:
Name: Shizuoka Cancer Center

Address:
City: Shizuoka
Zip: 411-8777
Country: Japan

Facility:
Name: National Cancer Center Hospital

Address:
City: Tokyo
Zip: 104-0045
Country: Japan

Facility:
Name: The Cancer Institute Hospital of JFCR

Address:
City: Tokyo
Zip: 135-8550
Country: Japan

Facility:
Name: Wakayama Medical University Hospital

Address:
City: Wakayama
Zip: 641-8510
Country: Japan

Facility:
Name: Chungbuk National University Hospital

Address:
City: Cheongju-si
Zip: 28644
Country: Korea, Republic of

Facility:
Name: Kyungpook National University Chilgok Hospital

Address:
City: Daegu
Zip: 41404
Country: Korea, Republic of

Facility:
Name: National Cancer Center

Address:
City: Goyang-si
Zip: 10408
Country: Korea, Republic of

Facility:
Name: St. Vincent's Hospital

Address:
City: Gyeonggi-do
Zip: 16247
Country: Korea, Republic of

Facility:
Name: Ajou University Medical Center

Address:
City: Gyeonggi-do
Zip: 16499
Country: Korea, Republic of

Facility:
Name: Pusan National University Yangsan Hospital

Address:
City: Gyeongsangnam-do
Zip: 50612
Country: Korea, Republic of

Facility:
Name: Gachon University Gil Medical Center

Address:
City: Incheon
Zip: 21565
Country: Korea, Republic of

Facility:
Name: Chonnam National University Hwasun Hospital

Address:
City: Jeollanam-do
Zip: 58128
Country: Korea, Republic of

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam-si
Zip: 463-707
Country: Korea, Republic of

Facility:
Name: Seoul National University Hospital

Address:
City: Seoul
Zip: 03080
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Samsung Medical Center

Address:
City: Seoul
Zip: 06351
Country: Korea, Republic of

Facility:
Name: Seoul St Mary's Hospital

Address:
City: Seoul
Zip: 06591
Country: Korea, Republic of

Facility:
Name: Korea University Guro Hospital

Address:
City: Seoul
Zip: 08308
Country: Korea, Republic of

Facility:
Name: Ulsan University Hosiptal

Address:
City: Ulsan
Zip: 44033
Country: Korea, Republic of

Facility:
Name: Meander Medisch Centrum

Address:
City: Amersfoort
Zip: 3813 TZ
Country: Netherlands

Facility:
Name: Amphia Ziekenhuis

Address:
City: Breda
Zip: 4818 CK
Country: Netherlands

Facility:
Name: Medisch Centrum Haaglanden, locatie Antoniushove

Address:
City: Leidschendam
Zip: 2262 BA
Country: Netherlands

Facility:
Name: Zuyderland Medisch Centrum - Sittard Geleen

Address:
City: Sittard-Geleen
Zip: 6162 BG
Country: Netherlands

Facility:
Name: Auckland City Hospital, Cancer and Blood Research

Address:
City: Auckland
Zip: 1023
Country: New Zealand

Facility:
Name: Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii

Address:
City: Gdansk
Zip: 80-214
Country: Poland

Facility:
Name: Szpital Kliniczny MSWiA z Warmi?sko-Mazurskim Centrum Onkologii; ZAK?.I O.KLINICZNY RADIOTERAPII

Address:
City: Olsztyn
Zip: 10-228
Country: Poland

Facility:
Name: Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii

Address:
City: Otwock
Zip: 05-400
Country: Poland

Facility:
Name: Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad; Klinika Nowot.Pluca i Klatki Piers

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii; Oddz. Onkologii Klin. i Chemioterapii

Address:
City: Wroc?aw
Zip: 53-413
Country: Poland

Facility:
Name: IPO de Coimbra; Servico de Oncologia Medica

Address:
City: Coimbra
Zip: 3000-075
Country: Portugal

Facility:
Name: Hospital da Luz; Departamento de Oncologia Medica

Address:
City: Lisboa
Zip: 1500-650
Country: Portugal

Facility:
Name: Hospital CUF Porto; Servico Pneumologia

Address:
City: Porto
Zip: 4100-180
Country: Portugal

Facility:
Name: IPO do Porto; Servico de Oncologia Medica

Address:
City: Porto
Zip: 4200-072
Country: Portugal

Facility:
Name: Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia

Address:
City: Badalona
Zip: 08916
Country: Spain

Facility:
Name: Hospital Provincial de Castellon; Servicio de Oncologia

Address:
City: Castellon de La Plana
Zip: 12002
Country: Spain

Facility:
Name: Hospital Son Llatzer; Servicio de Oncologia

Address:
City: Palma de Mallorca
Zip: 07198
Country: Spain

Facility:
Name: Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia

Address:
City: A Coruña
Zip: 15006
Country: Spain

Facility:
Name: Hospital Universitari Vall d'Hebron; Oncology

Address:
City: Barcelona
Zip: 08035
Country: Spain

Facility:
Name: Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

Address:
City: Madrid
Zip: 28009
Country: Spain

Facility:
Name: Hospital Universitario 12 de Octubre; Servicio de Oncologia

Address:
City: Madrid
Zip: 28041
Country: Spain

Facility:
Name: Hospital Universitario La Paz; Servicio de Oncologia

Address:
City: Madrid
Zip: 28046
Country: Spain

Facility:
Name: Hospital Regional Universitario Carlos Haya; Servicio de Oncologia

Address:
City: Malaga
Zip: 29011
Country: Spain

Facility:
Name: Hospital Universitario Virgen del Rocio; Servicio de Oncologia

Address:
City: Sevilla
Zip: 41013
Country: Spain

Facility:
Name: Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia

Address:
City: Sevilla
Zip: 41014
Country: Spain

Facility:
Name: China Medical University Hospital; Pulmonary and Critical Care Medicine

Address:
City: Taichung
Zip: 40447
Country: Taiwan

Facility:
Name: Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology

Address:
City: Taipei
Zip: 112
Country: Taiwan

Facility:
Name: Vajira Hospital

Address:
City: Bangkok
Zip: 10300
Country: Thailand

Facility:
Name: Rajavithi Hospital; Division of Medical Oncology

Address:
City: Bangkok
Zip: 10400
Country: Thailand

Facility:
Name: Ramathibodi Hospital; Medicine/Oncology; Clinical Research Center

Address:
City: Bangkok
Zip: 10400
Country: Thailand

Facility:
Name: Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory

Address:
City: Songkhla
Zip: 90110
Country: Thailand

Facility:
Name: Adana Baskent University Medical Faculty; Oncology

Address:
City: Adana
Zip: 01220
Country: Turkey

Facility:
Name: Ankara University Medical Faculty; Medikal Onkoloji

Address:
City: Ankara
Zip: 06100
Country: Turkey

Facility:
Name: Hacettepe Universitesi Tip Fakultesi Hastanesi

Address:
City: Ankara
Zip: 06100
Country: Turkey

Facility:
Name: Gazi University Medical Faculty, Oncology Hospital

Address:
City: Ankara
Zip: 06500
Country: Turkey

Facility:
Name: Ege University Medical Faculty; Medical Oncology Department

Address:
City: Bornova, ?zm?r
Zip: 35100
Country: Turkey

Facility:
Name: Dicle University Faculty of Medicine

Address:
City: Diyarbakir
Zip: 21280
Country: Turkey

Facility:
Name: Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

Address:
City: Edirne
Zip: 22030
Country: Turkey

Facility:
Name: Istanbul University Cerrahpasa Faculty of Medicine

Address:
City: Istanbul
Zip: 34098
Country: Turkey

Facility:
Name: Medipol University Medical Faculty; Oncology Department

Address:
City: Istanbul
Zip: 34214
Country: Turkey

Facility:
Name: Inonu University Faculty of Medicine Turgut Ozal Medical Center; Onkoloji, Elazig Yolu,

Address:
City: Malatya
Zip: 44280
Country: Turkey

Facility:
Name: Birmingham Heartlands Hospital

Address:
City: Birmingham
Zip: B9 5SS
Country: United Kingdom

Facility:
Name: Addenbrooke's NHS Trust

Address:
City: Cambridge
Zip: CB2 0QQ
Country: United Kingdom

Facility:
Name: Beatson West of Scotland Cancer Centre

Address:
City: Glasgow
Zip: G12 0YN
Country: United Kingdom

Facility:
Name: Calderdale & Huddersfield Nhs Trust; Oncology

Address:
City: Huddersfield
Zip: HD3 3EA
Country: United Kingdom

Facility:
Name: Leicester Royal Infirmary; Oncology Department

Address:
City: Leicester
Zip: LE1 5WW
Country: United Kingdom

Facility:
Name: Maidstone & Tonbridge Wells Hospital; Kent Oncology Center

Address:
City: Maidstone
Zip: ME16 9QQ
Country: United Kingdom

Facility:
Name: Christie Foundation Trust

Address:
City: Manchester
Zip: M20 4BX
Country: United Kingdom

Facility:
Name: Weston Park Hospital

Address:
City: Sheffield
Zip: S10 2SJ
Country: United Kingdom

Start date: August 24, 2020

Completion date: December 30, 2027

Lead sponsor:
Agency: Hoffmann-La Roche
Agency class: Industry

Source: Hoffmann-La Roche

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT04513925