A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

Trial Title: A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

NCT ID: NCT04619797

Condition: Non-small Cell Lung Cancer (NSCLC)

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Carboplatin
Pembrolizumab
Pemetrexed
Atezolizumab

Study type: Interventional

Study phase: Phase 2/Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Intervention:

Intervention type: Drug
Intervention name: Tiragolumab
Description: Tiragolumab at a fixed dose of 600 milligrams (mg), administered by intravenous (IV) infusion, every 3 weeks (Q3W) on Day 1 of each 21-day cycle.
Arm group label: Tiragolumab+Atezolizumab+Pemetrexed+Carboplatin or Cisplatin

Other name: MTIG7192A

Intervention type: Drug
Intervention name: Atezolizumab
Description: Atezolizumab at a fixed dose of 1200 mg, administered by IV infusion, Q3W on Day 1 of each 21-day cycle.
Arm group label: Tiragolumab+Atezolizumab+Pemetrexed+Carboplatin or Cisplatin

Other name: Tecentriq

Intervention type: Drug
Intervention name: Pemetrexed
Description: Pemetrexed 500 milligrams per square meter (mg/m^2), administered by IV infusion, Q3W on Day 1 of each 21-day cycle.
Arm group label: Placebo+Pembrolizumab+Pemetrexed+Carboplatin or Cisplatin
Arm group label: Tiragolumab+Atezolizumab+Pemetrexed+Carboplatin or Cisplatin

Intervention type: Drug
Intervention name: Carboplatin
Description: Carboplatin at dose of area under the concentration-time curve (AUC) of 5, administered by IV infusion, Q3W on Day 1 of each 21-day cycle for 4 cycles.
Arm group label: Placebo+Pembrolizumab+Pemetrexed+Carboplatin or Cisplatin
Arm group label: Tiragolumab+Atezolizumab+Pemetrexed+Carboplatin or Cisplatin

Intervention type: Drug
Intervention name: Cisplatin
Description: Cisplatin 75 mg/m^2, administered by IV infusion, Q3W on Day 1 of each 21-day cycle for 4 cycles.
Arm group label: Placebo+Pembrolizumab+Pemetrexed+Carboplatin or Cisplatin
Arm group label: Tiragolumab+Atezolizumab+Pemetrexed+Carboplatin or Cisplatin

Intervention type: Drug
Intervention name: Tiragolumab Matching Placebo
Description: Matching placebo, administered by IV infusion, Q3W on Day 1 of each 21-day cycle.
Arm group label: Placebo+Pembrolizumab+Pemetrexed+Carboplatin or Cisplatin

Intervention type: Drug
Intervention name: Pembrolizumab
Description: Pembrolizumab at a fixed dose of 200 mg, administered by IV infusion, Q3W, on Day 1 of each 21-day cycle.
Arm group label: Placebo+Pembrolizumab+Pemetrexed+Carboplatin or Cisplatin

Summary: The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase: - Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin - Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B).

Criteria for eligibility:
Criteria:
Key Inclusion Criteria: - Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 - Histologically or cytologically documented locally advanced unresectable or metastatic non-squamous NSCLC that is not eligible for curative surgery and/or definitive chemoradiotherapy - No prior systemic treatment for metastatic non-squamous NSCLC - Known tumor programmed death-ligand 1 (PD-L1) status - Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1) - Life expectancy >= 12 weeks - Adequate hematologic and end-organ function - Negative human immunodeficiency virus (HIV) test at screening - Serology test negative for active hepatitis B virus or active hepatitis C virus at screening. Key Exclusion Criteria: - Mutations in epidermal growth factor receptor (EGFR) gene or anaplastic lymphoma kinase (ALK) fusion oncogene - Pulmonary lymphoepithelioma-like carcinoma subtype of NSCLC - Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases - Active or history of autoimmune disease or immune deficiency - History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis - History of malignancy other than NSCLC within 5 years prior to randomization, with the exception of malignancies with a negligible risk of metastasis or death - Severe infection within 4 weeks prior to initiation of study treatment or any active infection that, in the opinion of the investigator, could impact patient safety - Treatment with investigational therapy within 28 days prior to initiation of study treatment - Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including anti-cytotoxic T lymphocyte-associated protein 4, anti-TIGIT, anti-PD-1, and anti-PD-L1 therapeutic antibodies - Treatment with systemic immunostimulatory agents within 4 weeks or 5 drug-elimination half-lives (whichever is longer) prior to initiation of study treatment - Treatment with systemic immunosuppressive medication within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during study treatment - Known allergy or hypersensitivity or other contraindication to any component of the chemotherapy regimen the participant may receive during the study - Women who are pregnant, or breastfeeding - Known targetable c-ROS oncogene 1 (ROS1) or BRAFV600E genomic aberration.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: UCLA

Address:
City: Los Angeles
Zip: 90095
Country: United States

Facility:
Name: Torrance Memorial Physician Network/Cancer Care

Address:
City: Torrance
Zip: 90505
Country: United States

Facility:
Name: PIH Health Whittier Hospital; NC

Address:
City: Whittier
Zip: 90602
Country: United States

Facility:
Name: SCRI Florida Cancer Specialists South

Address:
City: Fort Myers
Zip: 33916
Country: United States

Facility:
Name: Advent Health Orlando

Address:
City: Orlando
Zip: 32804
Country: United States

Facility:
Name: SCRI Florida Cancer Specialists North; Research Office North Region.

Address:
City: Saint Petersburg
Zip: 33705
Country: United States

Facility:
Name: Northwest Georgia Oncology Centers PC - Marietta

Address:
City: Marietta
Zip: 30060
Country: United States

Facility:
Name: Fort Wayne Medical Oncology and Hematology, Inc

Address:
City: Fort Wayne
Zip: 46804
Country: United States

Facility:
Name: Cancer Center of Kansas

Address:
City: Wichita
Zip: 67214
Country: United States

Facility:
Name: Baptist Health Lexington

Address:
City: Lexington
Zip: 40503
Country: United States

Facility:
Name: Memorial Sloan Kettering Cancer Center

Address:
City: New York
Zip: 10065
Country: United States

Facility:
Name: Tennessee Oncology Chattanooga

Address:
City: Chattanooga
Zip: 37404-3230
Country: United States

Facility:
Name: Sarah Cannon Research Institute / Tennessee Oncology

Address:
City: Nashville
Zip: 37203
Country: United States

Facility:
Name: Inova Schar Cancer Institute; Inova Schar Cancer Institute Infusion Pharmacy

Address:
City: Fairfax
Zip: 22031
Country: United States

Facility:
Name: Onze Lieve Vrouwziekenhuis Aalst

Address:
City: Aalst
Zip: 9300
Country: Belgium

Facility:
Name: Cliniques Universitaires St-Luc

Address:
City: Bruxelles
Zip: 1200
Country: Belgium

Facility:
Name: CHU UCL Mont-Godinne

Address:
City: Mont-godinne
Zip: 5530
Country: Belgium

Facility:
Name: Vitaz

Address:
City: Sint Niklaas
Zip: 9100
Country: Belgium

Facility:
Name: Crio - Centro Regional Integrado de Oncologia

Address:
City: Fortaleza
Zip: 60336-232
Country: Brazil

Facility:
Name: Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Address:
City: Ijui
Zip: 98700-000
Country: Brazil

Facility:
Name: Hospital das Clinicas - UFRGS

Address:
City: Porto Alegre
Zip: 90035-903
Country: Brazil

Facility:
Name: Hospital Nossa Senhora da Conceicao

Address:
City: Porto Alegre
Zip: 90040-373
Country: Brazil

Facility:
Name: Hospital de Cancer de Barretos

Address:
City: Barretos
Zip: 14784-400
Country: Brazil

Facility:
Name: Cross Cancer Institute

Address:
City: Edmonton
Zip: T6G 1Z2
Country: Canada

Facility:
Name: Royal Victoria Regional Health Centre

Address:
City: Barrie
Zip: L4M 6M2
Country: Canada

Facility:
Name: Lakeridge Health Oshawa

Address:
City: Oshawa
Zip: L1G 2B9
Country: Canada

Facility:
Name: Sault Area Hospital; Algoma District Cancer Program

Address:
City: Sault Ste. Marie
Zip: P6B 0A8
Country: Canada

Facility:
Name: Universite de Montreal - Hopital Maisonneuve-Rosemont

Address:
City: Montreal
Zip: H1T 2M4
Country: Canada

Facility:
Name: Beijing Cancer Hospital

Address:
City: Beijing
Zip: 100142
Country: China

Facility:
Name: Jilin Cancer Hospital

Address:
City: Changchun
Zip: 132013
Country: China

Facility:
Name: Xiangya Hospital Central South University

Address:
City: Changsha City
Zip: 410008
Country: China

Facility:
Name: Changzhou First People's Hospital; Oncology

Address:
City: Changzhou
Zip: 213003
Country: China

Facility:
Name: Affiliated Hospital of Chengde Medical University

Address:
City: Chengde City
Zip: 067020
Country: China

Facility:
Name: Sichuan Cancer Hospital

Address:
City: Chengdu City
Zip: 610041
Country: China

Facility:
Name: West China Hospital - Sichuan University

Address:
City: Chengdu City
Zip: 610047
Country: China

Facility:
Name: Dongguan People's Hospital

Address:
City: Dongguan
Zip: 511700
Country: China

Facility:
Name: Anhui Provincial Hospital; Respiratory Department

Address:
City: Hefei
Zip: 230088
Country: China

Facility:
Name: Jinan Central Hospital

Address:
City: Jinan City
Zip: 250013
Country: China

Facility:
Name: Linyishi Cancer Hospital

Address:
City: Linyi City
Zip: 276034
Country: China

Facility:
Name: Pingxiang People Hospital

Address:
City: Pingxiang City
Zip: 337000
Country: China

Facility:
Name: Qingdao Central Hospital; Department of Respiratory and Critical Care Medicine

Address:
City: Qingdao City
Zip: 266042
Country: China

Facility:
Name: Weifang People's Hospital

Address:
City: Weifang City
Zip: 261041
Country: China

Facility:
Name: Hubei Cancer Hospital

Address:
City: Wuhan
Zip: 430079
Country: China

Facility:
Name: The First Affiliated Hospital of Xian Jiao Tong University

Address:
City: Xi'an City
Zip: 710061
Country: China

Facility:
Name: The First Affiliated Hospital of Xinxiang Medical University

Address:
City: Xinxiang City
Zip: 453000
Country: China

Facility:
Name: The First Affiliated Hospital of Zhengzhou University

Address:
City: Zhengzhou
Zip: 450052
Country: China

Facility:
Name: Rigshospitalet; Onkologisk Klinik

Address:
City: København Ø
Zip: 2100
Country: Denmark

Facility:
Name: Odense Universitetshospital, Onkologisk Afdeling R

Address:
City: Odense C
Zip: 5000
Country: Denmark

Facility:
Name: Sjællands Universitetshospital, Roskilde; Klinisk Onkologisk Afdeling og Palliativ Enhed

Address:
City: Roskilde
Zip: 4000
Country: Denmark

Facility:
Name: Institut Bergonie; Pneumology

Address:
City: Bordeaux
Zip: 33076
Country: France

Facility:
Name: Hopital Nord; Pneumologie

Address:
City: Marseille cedex 20
Zip: 13915
Country: France

Facility:
Name: Hopital de Pontchaillou; Service de Pneumologie

Address:
City: Rennes
Zip: 35033
Country: France

Facility:
Name: CHU Strasbourg - Nouvel Hopital Civil

Address:
City: Strasbourg
Zip: 67091
Country: France

Facility:
Name: CHU de Toulouse - Hôpital Larrey; Service de pneumologie et oncologie pneumologique

Address:
City: Toulouse cedex 9
Zip: 31100
Country: France

Facility:
Name: Helios Klinikum Emil von Behring GmbH

Address:
City: Berlin
Zip: 14165
Country: Germany

Facility:
Name: Klinikum Chemnitz gGmbH

Address:
City: Chemnitz
Zip: 09116
Country: Germany

Facility:
Name: St. Vincentius Kliniken Karlsruhe

Address:
City: Karlsruhe
Zip: 76137
Country: Germany

Facility:
Name: Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie

Address:
City: Mainz
Zip: 55131
Country: Germany

Facility:
Name: Klinikum der Philipps-Universität Marburg

Address:
City: Marburg
Zip: 35032
Country: Germany

Facility:
Name: Hong Kong United Oncology Centre

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Queen Mary Hospital; Dept. of Clinical Oncology

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Queen Mary Hospital; Medicine & Respiratory

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Tuen Mun Hospital; Clinical Onc

Address:
City: Hong Kong
Country: Hong Kong

Facility:
Name: Prince of Wales Hospital; Department of Clinical Onocology

Address:
City: Shatin
Country: Hong Kong

Facility:
Name: Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica

Address:
City: Bologna
Zip: 40138
Country: Italy

Facility:
Name: Centro Di Riferimento Oncologico; Struttura Operativa Complessa Di Oncologia Medica B

Address:
City: Aviano
Zip: 33081
Country: Italy

Facility:
Name: A.O. Villa Scassi; Oncologia Medica

Address:
City: Genova
Zip: 16149
Country: Italy

Facility:
Name: Asst Papa Giovanni XXIII; Oncologia Medica

Address:
City: Bergamo
Zip: 24127
Country: Italy

Facility:
Name: ASST Spedali Civili di Brescia

Address:
City: Brescia
Zip: 25123
Country: Italy

Facility:
Name: Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1

Address:
City: Firenze
Zip: 50139
Country: Italy

Facility:
Name: Kyushu University Hospital

Address:
City: Fukuoka
Zip: 812-8582
Country: Japan

Facility:
Name: Kurume University Hospital

Address:
City: Fukuoka
Zip: 830-0011
Country: Japan

Facility:
Name: Hiroshima University Hospital

Address:
City: Hiroshima
Zip: 734-8551
Country: Japan

Facility:
Name: Takarazuka City Hospital

Address:
City: Hyogo
Zip: 665-0827
Country: Japan

Facility:
Name: University Hospital Kyoto Prefectural University of Medicine

Address:
City: Kyoto
Zip: 602-8566
Country: Japan

Facility:
Name: Sendai Kousei Hospital

Address:
City: Miyagi
Zip: 981-0914
Country: Japan

Facility:
Name: Osaka International Cancer Institute

Address:
City: Osaka
Zip: 541-8567
Country: Japan

Facility:
Name: Kansai Medical University Hospital

Address:
City: Osaka
Zip: 573-1191
Country: Japan

Facility:
Name: Kindai University Hospital

Address:
City: Osaka
Zip: 589-8511
Country: Japan

Facility:
Name: NHO Kinki Chuo Chest Medical Center

Address:
City: Osaka
Zip: 591-8555
Country: Japan

Facility:
Name: Saitama Cancer Center

Address:
City: Saitama
Zip: 362-0806
Country: Japan

Facility:
Name: The Cancer Institute Hospital of JFCR

Address:
City: Tokyo
Zip: 135-8550
Country: Japan

Facility:
Name: Tokyo Medical University Hachioji Medical Center

Address:
City: Tokyo
Zip: 193-0998
Country: Japan

Facility:
Name: Wakayama Medical University Hospital

Address:
City: Wakayama
Zip: 641-8510
Country: Japan

Facility:
Name: Kosin University Gospel Hospital

Address:
City: Busan
Zip: 49267
Country: Korea, Republic of

Facility:
Name: Kyungpook National University Chilgok Hospital

Address:
City: Daegu
Zip: 41404
Country: Korea, Republic of

Facility:
Name: Chungnam National University Hospital

Address:
City: Daejeon
Zip: 35015
Country: Korea, Republic of

Facility:
Name: St. Vincent's Hospital

Address:
City: Gyeonggi-do
Zip: 16247
Country: Korea, Republic of

Facility:
Name: Samsung Changwon Hospital

Address:
City: Gyeongsangnam-do
Zip: 51353
Country: Korea, Republic of

Facility:
Name: Seoul National University Hospital

Address:
City: Seoul
Zip: 03080
Country: Korea, Republic of

Facility:
Name: Kangbuk Samsung Hospital

Address:
City: Seoul
Zip: 03181
Country: Korea, Republic of

Facility:
Name: Severance Hospital, Yonsei University Health System

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Seoul St Mary's Hospital

Address:
City: Seoul
Zip: 06591
Country: Korea, Republic of

Facility:
Name: Health Pharma Professional Research

Address:
City: Cdmx
Zip: 03100
Country: Mexico

Facility:
Name: Cuidados oncologicos

Address:
City: Querétaro
Zip: 76000
Country: Mexico

Facility:
Name: Oncologico Potosino

Address:
City: San Luis Potosí
Zip: 78209
Country: Mexico

Facility:
Name: ARKE Estudios Clínicos S.A. de C.V.

Address:
City: Ciudad de México
Zip: 06700
Country: Mexico

Facility:
Name: Auckland City Hospital, Cancer and Blood Research

Address:
City: Auckland
Zip: 1023
Country: New Zealand

Facility:
Name: Waikato Hospital - Cancer and Blood Research Trials Unit; Regional Cancer Centre

Address:
City: Hamilton
Zip: 3204
Country: New Zealand

Facility:
Name: Palmerston North Hospital

Address:
City: Palmerston North
Zip: 4410
Country: New Zealand

Facility:
Name: Tauranga Hospital, Clinical Trials Unit; BOP Clinical School

Address:
City: Tauranga
Zip: 3112
Country: New Zealand

Facility:
Name: Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna

Address:
City: ?ód?
Zip: 90-338
Country: Poland

Facility:
Name: Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie; Oddzial onkologii z pododdzialem chemioterapii

Address:
City: Olsztyn
Zip: 10-357
Country: Poland

Facility:
Name: ICO L'Hospitalet; Servicio de oncologia medica

Address:
City: L'Hospitalet de Llobregat
Zip: 08908
Country: Spain

Facility:
Name: Hospital Son Llatzer; Servicio de Oncologia

Address:
City: Palma de Mallorca
Zip: 07198
Country: Spain

Facility:
Name: Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia

Address:
City: A Coruña
Zip: 15006
Country: Spain

Facility:
Name: Complejo Hospitalario Universitario Insular?Materno Infantil; Servicio de Oncologia

Address:
City: Las Palmas de Gran Canaria
Zip: 35016
Country: Spain

Facility:
Name: Hospital del Mar; Servicio de Oncologia

Address:
City: Barcelona
Zip: 08003
Country: Spain

Facility:
Name: Hospital Clinic Barcelona; Servicio de oncologia

Address:
City: Barcelona
Zip: 08036
Country: Spain

Facility:
Name: Hospital Lucus Augusti; Servicio de Oncologia

Address:
City: Lugo
Zip: 27003
Country: Spain

Facility:
Name: Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

Address:
City: Madrid
Zip: 28009
Country: Spain

Facility:
Name: Hospital Universitario La Paz; Servicio de Oncologia

Address:
City: Madrid
Zip: 28046
Country: Spain

Facility:
Name: Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia

Address:
City: Sevilla
Zip: 41014
Country: Spain

Facility:
Name: Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia

Address:
City: Valencia
Zip: 46010
Country: Spain

Facility:
Name: Kantonsspital Aarau

Address:
City: Aarau
Zip: 5001
Country: Switzerland

Facility:
Name: Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie

Address:
City: Chur
Zip: 7000
Country: Switzerland

Facility:
Name: UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie

Address:
City: Zürich
Zip: 8091
Country: Switzerland

Facility:
Name: Changhua Christian Hospital

Address:
City: Chang Hua
Zip: 500
Country: Taiwan

Facility:
Name: China Medical University Hospital

Address:
City: Taichung
Zip: 40447
Country: Taiwan

Facility:
Name: Taipei Veterans General Hospital

Address:
City: Taipei City
Zip: 11217
Country: Taiwan

Facility:
Name: Vajira Hospital

Address:
City: Bangkok
Zip: 10300
Country: Thailand

Facility:
Name: Chulalongkorn Hospital; Medical Oncology

Address:
City: Bangkok
Zip: 10330
Country: Thailand

Facility:
Name: Pramongkutklao Hospital; Medicine - Medical Oncology Unit

Address:
City: Bangkok
Zip: 10400
Country: Thailand

Facility:
Name: Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology

Address:
City: Bangkok
Zip: 10700
Country: Thailand

Facility:
Name: Maharaj Nakorn Chiang Mai Hospital; Department of Medicine

Address:
City: ChiangMai
Zip: 50200
Country: Thailand

Facility:
Name: Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory

Address:
City: Songkhla
Zip: 90110
Country: Thailand

Facility:
Name: Adana Baskent University Medical Faculty; Oncology

Address:
City: Adana
Zip: 01220
Country: Turkey

Facility:
Name: Ankara Bilkent City Hospital

Address:
City: Ankara
Zip: 06490
Country: Turkey

Facility:
Name: Liv Hospital Ankara; Medical Oncology

Address:
City: Ankara
Zip: 06680
Country: Turkey

Facility:
Name: Dicle University Faculty of Medicine

Address:
City: Diyarbakir
Zip: 21280
Country: Turkey

Facility:
Name: Trakya University Medical Faculty

Address:
City: Edirne
Zip: 22030
Country: Turkey

Facility:
Name: Istanbul University Cerrahpasa Medical Faculty

Address:
City: Istanbul
Zip: 34000
Country: Turkey

Facility:
Name: Medeniyet University Goztepe Training and Research Hospital.

Address:
City: Kadiköy
Zip: 34722
Country: Turkey

Facility:
Name: Royal Cornwall Hospital; Dept of Clinical Oncology

Address:
City: Cornwall
Zip: TR1 3LQ
Country: United Kingdom

Facility:
Name: Castle Hill Hospital; The Queen's Centre for Oncology & Haematology

Address:
City: Hull
Zip: HU16 5JQ
Country: United Kingdom

Facility:
Name: Barts & London School of Med; Medical Oncology

Address:
City: London
Zip: EC1A 7BE
Country: United Kingdom

Facility:
Name: Guy'S Hospital; Oncology Unit

Address:
City: London
Zip: SE1 9RT
Country: United Kingdom

Facility:
Name: Nottingham City Hospital

Address:
City: Nottingham
Zip: NG5 1PB
Country: United Kingdom

Facility:
Name: New Cross Hospital

Address:
City: Wolverhampton
Zip: WV10 0QP
Country: United Kingdom

Start date: December 14, 2020

Completion date: May 14, 2027

Lead sponsor:
Agency: Hoffmann-La Roche
Agency class: Industry

Source: Hoffmann-La Roche

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT04619797