Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Trial Title: Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

NCT ID: NCT04685135

Condition: Metastatic Non Small Cell Lung Cancer
Advanced Non Small Cell Lung Cancer

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Docetaxel
Adagrasib

Conditions: Keywords:
KRAS G12C
Non-small cell lung cancer
NSCLC
Metastatic Cancer
Docetaxel
Phase 3 Clinical Trial
Adagrasib
KRAS
KRAZATI

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: MRTX849
Description: 21 day cycles
Arm group label: MRTX849

Other name: adagrasib

Other name: KRAZATI

Intervention type: Drug
Intervention name: Docetaxel
Description: 21 day cycles
Arm group label: Docetaxel

Other name: Taxotere

Summary: This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation. - Candidacy to receive treatment with docetaxel. Crossover Inclusion Criteria: - Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR - ECOG performance status 0-2 Exclusion Criteria: - Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib). - Active brain metastases. Crossover Exclusion Criteria: - Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: TOI Clinical Research (ICIR)

Address:
City: Cerritos
Zip: 90703
Country: United States

Facility:
Name: City of Hope - Duarte (Main Campus)

Address:
City: Duarte
Zip: 91010
Country: United States

Facility:
Name: Providence Medical Group - Santa Rosa

Address:
City: Santa Rosa
Zip: 95403
Country: United States

Facility:
Name: SCL Health - Saint Joseph Hospital Cancer Center

Address:
City: Lafayette
Zip: 80026
Country: United States

Facility:
Name: Rocky Mountain Cancer Centers - Lone Tree

Address:
City: Lone Tree
Zip: 80124
Country: United States

Facility:
Name: Holy Cross Health Fort Lauderdale - Holy Cross Hospital

Address:
City: Fort Lauderdale
Zip: 33308
Country: United States

Facility:
Name: 21st Century Oncology of Jacksonville - North Lee Street

Address:
City: Jacksonville
Zip: 32204
Country: United States

Facility:
Name: Cancer Specialists of North Florida - Southpoint

Address:
City: Jacksonville
Zip: 32256
Country: United States

Facility:
Name: Orlando Health University of Florida Health Cancer Center - Head and Neck Center

Address:
City: Orlando
Zip: 32806
Country: United States

Facility:
Name: USOR - Woodlands Medical Specialists

Address:
City: Pensacola
Zip: 32503
Country: United States

Facility:
Name: University Cancer & Blood Center (UCBC) - Athens

Address:
City: Athens
Zip: 30607
Country: United States

Facility:
Name: Northwest Georgia Oncology Centers Wellstar - Marietta

Address:
City: Marietta
Zip: 30060
Country: United States

Facility:
Name: University of Illinois Hospital & Health Sciences System

Address:
City: Chicago
Zip: 60612
Country: United States

Facility:
Name: University of Chicago

Address:
City: Chicago
Zip: 60637
Country: United States

Facility:
Name: Illinois Cancer Specialists - Niles

Address:
City: Niles
Zip: 60714
Country: United States

Facility:
Name: Goshen Center for Cancer Care

Address:
City: Goshen
Zip: 46526
Country: United States

Facility:
Name: Franciscan Health Cancer Center Indianapolis

Address:
City: Indianapolis
Zip: 46237
Country: United States

Facility:
Name: Franciscan Health Munster

Address:
City: Munster
Zip: 46321
Country: United States

Facility:
Name: University of Kansas Medical Center

Address:
City: Westwood
Zip: 66205
Country: United States

Facility:
Name: Cancer Center of Kansas - Wichita - Heritage Plaza

Address:
City: Wichita
Zip: 67214
Country: United States

Facility:
Name: Baptist Health Lexington

Address:
City: Lexington
Zip: 40503
Country: United States

Facility:
Name: Tulane University

Address:
City: New Orleans
Zip: 70112
Country: United States

Facility:
Name: New England Cancer Specialists - Scarborough

Address:
City: Scarborough
Zip: 04074
Country: United States

Facility:
Name: Frederick Health

Address:
City: Frederick
Zip: 21702
Country: United States

Facility:
Name: Ascension Providence Cancer Center - Southfield

Address:
City: Southfield
Zip: 48075
Country: United States

Facility:
Name: Central Care Cancer Center - Bolivar

Address:
City: Bolivar
Zip: 65613
Country: United States

Facility:
Name: St. Vincent Healthcare Cancer Centers of Montana

Address:
City: Billings
Zip: 59101
Country: United States

Facility:
Name: Sisters of Charity of Leavenworth Health St. Marys

Address:
City: Billings
Zip: 59102
Country: United States

Facility:
Name: Astera Cancer Care - East Brunswick

Address:
City: East Brunswick
Zip: 08816
Country: United States

Facility:
Name: Holy Name Medical Center

Address:
City: Teaneck
Zip: 07666
Country: United States

Facility:
Name: SUNY Upstate Medical University

Address:
City: Syracuse
Zip: 13210-2306
Country: United States

Facility:
Name: University Hospitals Cleveland Medical Center

Address:
City: Cleveland
Zip: 44106
Country: United States

Facility:
Name: Kettering Health Cancer Center - Main Campus

Address:
City: Kettering
Zip: 45429
Country: United States

Facility:
Name: Oregon Oncology Specialists

Address:
City: Salem
Zip: 97301
Country: United States

Facility:
Name: Lifespan Cancer Institute - Rhode Island Hospital

Address:
City: Providence
Zip: 02903
Country: United States

Facility:
Name: Prisma Health Cancer Institute - Faris Road

Address:
City: Greenville
Zip: 29605
Country: United States

Facility:
Name: Avera Cancer Institute

Address:
City: Sioux Falls
Zip: 57105
Country: United States

Facility:
Name: Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North

Address:
City: Arlington
Zip: 76012
Country: United States

Facility:
Name: Texas Oncology - South Austin

Address:
City: Austin
Zip: 78745
Country: United States

Facility:
Name: Local Institution - 012-999

Address:
City: Irving
Zip: 75063
Country: United States

Facility:
Name: Texas Oncology - Sherman

Address:
City: Sherman
Zip: 75090
Country: United States

Facility:
Name: Utah Cancer Specialists - UCS Cancer Center

Address:
City: Salt Lake City
Zip: 84106
Country: United States

Facility:
Name: UVA Health - University Hospital

Address:
City: Charlottesville
Zip: 22908-0674
Country: United States

Facility:
Name: NEXT Virginia

Address:
City: Fairfax
Zip: 22031
Country: United States

Facility:
Name: Flinders Medical Centre

Address:
City: Bedford Park
Zip: 5042
Country: Australia

Facility:
Name: Monash Health

Address:
City: Clayton
Zip: 3168
Country: Australia

Facility:
Name: Townsville University Hospital

Address:
City: Douglas
Zip: 4814
Country: Australia

Facility:
Name: GenesisCare - North Shore

Address:
City: St. Leonards
Zip: 2065
Country: Australia

Facility:
Name: The Tweed Hospital

Address:
City: Tweed Heads
Zip: 2485
Country: Australia

Facility:
Name: Cancer Care Wollongong

Address:
City: Wollongong
Zip: 2500
Country: Australia

Facility:
Name: Princess Alexandra Hospital

Address:
City: Woolloongabba
Zip: 4102
Country: Australia

Facility:
Name: Klinikum Klagenfurt Am Worthersee

Address:
City: Klagenfurt Am Woerthersee
Zip: 9020
Country: Austria

Facility:
Name: Uniklinikum Salzburg

Address:
City: Salzburg
Zip: 5020
Country: Austria

Facility:
Name: Wiener Gesundheitsverbund - Klinik Ottakring

Address:
City: Wien
Zip: 1160
Country: Austria

Facility:
Name: Universitair Ziekenhuis Brussel

Address:
City: Brussel
Zip: 1090
Country: Belgium

Facility:
Name: Grand Hopital de Charleroi - Notre Dame

Address:
City: Charleroi
Zip: 6000
Country: Belgium

Facility:
Name: Universitair Ziekenhuis Antwerpen

Address:
City: Edegem
Zip: 2650
Country: Belgium

Facility:
Name: Algemeen Ziekenhuis Maria Middelares

Address:
City: Gent
Zip: 9000
Country: Belgium

Facility:
Name: Jessa Ziekenhuis - Campus Virga Jesse

Address:
City: Hasselt
Zip: 3500
Country: Belgium

Facility:
Name: Algemeen Ziekenhuis Delta - Campus Rumbeke

Address:
City: Roeselare
Zip: 8800
Country: Belgium

Facility:
Name: Algemeen Ziekenhuis Glorieux Ronse

Address:
City: Ronse
Zip: 9600
Country: Belgium

Facility:
Name: Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne

Address:
City: Yvoir
Zip: B-5530
Country: Belgium

Facility:
Name: Multiscan - Ambulance klinicke onkologie se stacionarem - Horovice

Address:
City: Horovice
Zip: 268 31
Country: Czechia

Facility:
Name: Fakultni Nemocnice Olomouc

Address:
City: Olomouc
Zip: 779 00
Country: Czechia

Facility:
Name: Fakultni nemocnice Bulovka

Address:
City: Praha 8 - Liben
Zip: 180 81
Country: Czechia

Facility:
Name: Hopital Morvan

Address:
City: Brest
Zip: 29200
Country: France

Facility:
Name: Hopital Louis Pradel

Address:
City: Bron
Zip: 69500
Country: France

Facility:
Name: Centre Hospitalier Universitaire de Caen Normandie

Address:
City: Caen Cedex 09
Zip: 14033
Country: France

Facility:
Name: Centre Francois Baclesse

Address:
City: Caen Cedex 5
Zip: 14076
Country: France

Facility:
Name: Centre Hospitalier Intercommunal de Creteil

Address:
City: Creteil
Zip: 94000
Country: France

Facility:
Name: Centre Georges Francois Leclerc

Address:
City: Dijon cedex
Zip: 21079
Country: France

Facility:
Name: LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone

Address:
City: Gleize
Zip: 69400
Country: France

Facility:
Name: Hopital Michallon

Address:
City: La Tronche
Zip: 38700
Country: France

Facility:
Name: Centre Hospitalier Regional Universitaire de Lille

Address:
City: Lille Cedex
Zip: 59037
Country: France

Facility:
Name: Centre Hospitalier Universitaire Dupuytren 1

Address:
City: Limoges cedex
Zip: 87042
Country: France

Facility:
Name: Institut Paoli-Calmettes

Address:
City: Marseille
Zip: 13009
Country: France

Facility:
Name: Hopital Nord de Marseille

Address:
City: Marseille
Zip: 13015
Country: France

Facility:
Name: Hopital Arnaud de Villeneuve

Address:
City: Montpellier
Zip: 34090
Country: France

Facility:
Name: Hopital Emile Muller

Address:
City: Mulhouse
Zip: 68100
Country: France

Facility:
Name: Centre Antoine Lacassagne

Address:
City: Nice Cedex 2
Zip: 06189
Country: France

Facility:
Name: Centre Hospitalier de Cornouaille - Hopital Laennec

Address:
City: Quimper
Zip: 29107
Country: France

Facility:
Name: Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau

Address:
City: Saint Herblain
Zip: 44805
Country: France

Facility:
Name: Hopital Civil

Address:
City: Strasbourg cedex
Zip: 67091
Country: France

Facility:
Name: Institut de Cancerologie Strasbourg Europe

Address:
City: Strasbourg
Zip: 67200
Country: France

Facility:
Name: Hopital Bretonneau

Address:
City: Tours Cedex 9
Zip: 37044
Country: France

Facility:
Name: Gustave Roussy

Address:
City: Villejuif
Zip: 94805
Country: France

Facility:
Name: Zentralklinik Bad Berka

Address:
City: Bad Berka
Zip: 99437
Country: Germany

Facility:
Name: Universitatsklinikum Bonn

Address:
City: Bonn
Zip: 53127
Country: Germany

Facility:
Name: Kliniken Essen-Mitte - Evangelische Huyssens-Stiftung

Address:
City: Essen
Zip: 45136
Country: Germany

Facility:
Name: Asklepios Fachkliniken Munchen-Gauting

Address:
City: Gauting
Zip: 82131
Country: Germany

Facility:
Name: Universitatsklinikum Gieen und Marburg - Gieen

Address:
City: Giessen
Zip: 35392
Country: Germany

Facility:
Name: LungenClinic Grosshansdorf

Address:
City: Grohansdorf
Zip: 22927
Country: Germany

Facility:
Name: Krankenhaus Martha-Maria Halle-Dolau

Address:
City: Halle
Zip: 06120
Country: Germany

Facility:
Name: Universitatsklinikum Jena

Address:
City: Jena
Zip: 07747
Country: Germany

Facility:
Name: Klinikum Kassel

Address:
City: Kassel
Zip: 34125
Country: Germany

Facility:
Name: Klinikum Koln-Merheim

Address:
City: Koln
Zip: 51109
Country: Germany

Facility:
Name: SLK-Kliniken - Fachklinik Lowenstein

Address:
City: Lowenstein
Zip: 74245
Country: Germany

Facility:
Name: Universitatsklinikum Schleswig-Holstein - Campus Lubeck

Address:
City: Lubeck
Zip: 23538
Country: Germany

Facility:
Name: Munchen Klinik Bogenhausen

Address:
City: Munchen
Zip: 81925
Country: Germany

Facility:
Name: Sana Klinikum Offenbach

Address:
City: Offenbach
Zip: 63069
Country: Germany

Facility:
Name: Pius-Hospital Oldenburg

Address:
City: Oldenburg
Zip: 26121
Country: Germany

Facility:
Name: Henry Dunant Hospital Center

Address:
City: Athens
Zip: 11526
Country: Greece

Facility:
Name: General Hospital for Thoracic Diseases Sotiria

Address:
City: Athens
Zip: 11527
Country: Greece

Facility:
Name: University General Hospital of Heraklion (PAGNI)

Address:
City: Heraklion
Zip: 71110
Country: Greece

Facility:
Name: University General Hospital of Larissa

Address:
City: Larissa
Zip: 41110
Country: Greece

Facility:
Name: "General Oncology Hospital of Kifisias "Agioi Anargyroi""

Address:
City: Nea Kifisia
Zip: 145 64
Country: Greece

Facility:
Name: Metropolitan Hospital

Address:
City: Peiraias
Zip: 185 47
Country: Greece

Facility:
Name: BioClinic Thessaloniki

Address:
City: Thessaloniki
Zip: 54622
Country: Greece

Facility:
Name: Interbalkan Medical Center of Thessaloniki

Address:
City: Thessaloniki
Zip: 57001
Country: Greece

Facility:
Name: General Hospital of Thessaloniki George Papanikolaou

Address:
City: Thessaloniki
Zip: 57010
Country: Greece

Facility:
Name: Anassa General Clinic

Address:
City: Volos
Zip: 38333
Country: Greece

Facility:
Name: Humanity & Health Clinical Trial Centre

Address:
City: Central
Zip: 0
Country: Hong Kong

Facility:
Name: Prince of Wales Hospital - Hong Kong

Address:
City: Hong Kong
Zip: 0
Country: Hong Kong

Facility:
Name: Hong Kong United Oncology Centre

Address:
City: Kowloon
Zip: 0
Country: Hong Kong

Facility:
Name: Semmelweis Egyetem - Pulmonologiai Klinika

Address:
City: Budapest
Zip: 1083
Country: Hungary

Facility:
Name: Orszagos Koranyi Pulmonologiai Intezet

Address:
City: Budapest
Zip: 1121
Country: Hungary

Facility:
Name: Orszagos Onkologiai Intezet

Address:
City: Budapest
Zip: 1122
Country: Hungary

Facility:
Name: Matrai Gyogyintezet

Address:
City: Gyongyos
Zip: 3200
Country: Hungary

Facility:
Name: Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaz

Address:
City: Gyula
Zip: 5700
Country: Hungary

Facility:
Name: Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz

Address:
City: Szekesfehervar
Zip: 8000
Country: Hungary

Facility:
Name: Reformatus Pulmonologiai Centrum

Address:
City: Torokbalint
Zip: 2045
Country: Hungary

Facility:
Name: The Meath Foundation

Address:
City: Tallaght
Zip: D24 NR04
Country: Ireland

Facility:
Name: St. Vincents University Hospital

Address:
City: Dublin
Zip: 4
Country: Ireland

Facility:
Name: Beaumont Hospital - Dublin

Address:
City: Dublin
Zip: 9
Country: Ireland

Facility:
Name: St. Jamess Hospital

Address:
City: Dublin
Zip: D08 NHY1
Country: Ireland

Facility:
Name: University Hospital Galway

Address:
City: Galway
Zip: H91 YR71
Country: Ireland

Facility:
Name: University Hospital Limerick

Address:
City: Limerick
Zip: V94 F858
Country: Ireland

Facility:
Name: Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo - Alessandria

Address:
City: Alessandria
Zip: 15121
Country: Italy

Facility:
Name: Azienda Ospedaliera San Giuseppe Moscati - Avellino

Address:
City: Avellino
Zip: 83100
Country: Italy

Facility:
Name: Centro di Riferimento Oncologico

Address:
City: Aviano
Zip: 33081
Country: Italy

Facility:
Name: Istituto Tumori Bari Giovanni Paolo II - IRCCS

Address:
City: Bari
Zip: 70124
Country: Italy

Facility:
Name: Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia

Address:
City: Brescia
Zip: 25123
Country: Italy

Facility:
Name: Istituto di Candiolo - Fondazione del Piemonte per lOncologia

Address:
City: Candiolo
Zip: 10060
Country: Italy

Facility:
Name: Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi

Address:
City: Catania
Zip: 95122
Country: Italy

Facility:
Name: Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele

Address:
City: Catania
Zip: 95123
Country: Italy

Facility:
Name: Azienda Ospedaliero - Universitaria Careggi

Address:
City: Firenze
Zip: 50134
Country: Italy

Facility:
Name: ASL 3 Genovese - Ospedale Villa Scassi - Sampierdarena

Address:
City: Genova
Zip: 16100
Country: Italy

Facility:
Name: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino

Address:
City: Genova
Zip: 16132
Country: Italy

Facility:
Name: Ospedale Vito Fazzi Lecce

Address:
City: Lecce
Zip: 73100
Country: Italy

Facility:
Name: "Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"

Address:
City: Meldola
Zip: 47014
Country: Italy

Facility:
Name: Fondazione IRCCS - Istituto Nazionale dei Tumori

Address:
City: Milano
Zip: 20133
Country: Italy

Facility:
Name: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele

Address:
City: Milan
Zip: 20132
Country: Italy

Facility:
Name: Istituto Europeo di Oncologia

Address:
City: Milan
Zip: 20141
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: Istituto Nazionale Tumori IRCCS Fondazione G. Pascale

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: Azienda Ospedaliero-Universitaria Maggiore della Carita di Novara

Address:
City: Novara
Zip: 28100
Country: Italy

Facility:
Name: Azienda Ospedaliero-Universitaria di Parma

Address:
City: Parma
Zip: 43126
Country: Italy

Facility:
Name: Azienda Ospedaliera di Perugia - Santa Maria della Misericordia

Address:
City: Perugia
Zip: 06132
Country: Italy

Facility:
Name: Azienda Ospedaliera Ospedali Riuniti Marche Nord

Address:
City: Pesaro
Zip: 61122
Country: Italy

Facility:
Name: Ospedale Santa Maria delle Croci di Ravenna

Address:
City: Ravenna
Zip: 48121
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria Integrata Verona

Address:
City: Verona
Zip: 37126
Country: Italy

Facility:
Name: Pusan National University Hospital

Address:
City: Busan-si
Zip: 49241
Country: Korea, Republic of

Facility:
Name: Inje University Haeundae Paik Hospital

Address:
City: Busan
Zip: 48108
Country: Korea, Republic of

Facility:
Name: Kosin University Gospel Hospital

Address:
City: Busan
Zip: 602702
Country: Korea, Republic of

Facility:
Name: Chungbuk National University Hospital

Address:
City: Cheongju-si
Zip: 28644
Country: Korea, Republic of

Facility:
Name: Kyungpook National University Chilgok Hospital

Address:
City: Daegu
Zip: 41404
Country: Korea, Republic of

Facility:
Name: Keimyung University Dongsan Hospital

Address:
City: Daegu
Zip: 42601
Country: Korea, Republic of

Facility:
Name: Gachon University Gil Medical Center

Address:
City: Incheon
Zip: 21565
Country: Korea, Republic of

Facility:
Name: Inha University Hospital

Address:
City: Jung-Gu
Zip: 400-712
Country: Korea, Republic of

Facility:
Name: Cha Bundang Medical Center

Address:
City: Seongnam-si
Zip: 13496
Country: Korea, Republic of

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam-si
Zip: 13620
Country: Korea, Republic of

Facility:
Name: Korea University Anam Hospital

Address:
City: Seoul
Zip: 02841
Country: Korea, Republic of

Facility:
Name: Severance Hospital - Yonsei Cancer Center

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Facility:
Name: Konkuk University Medical Center

Address:
City: Seoul
Zip: 05080
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: The Catholic University of Korea - Seoul St. Marys Hospital

Address:
City: Seoul
Zip: 06591
Country: Korea, Republic of

Facility:
Name: Catholic University of Korea Saint Vincents Hospital

Address:
City: Suwon-Si
Zip: 16247
Country: Korea, Republic of

Facility:
Name: Ajou University Hospital

Address:
City: Suwon-si
Zip: 16499
Country: Korea, Republic of

Facility:
Name: Amsterdam Universitair Medische Centra (UMC) - Locatie Vrije Universiteit Medisch Centrum

Address:
City: Amsterdam
Zip: 1081 HV
Country: Netherlands

Facility:
Name: Hagaziekenhuis Van Den Haag - Leyweg

Address:
City: Den Haag
Zip: 2545 AA
Country: Netherlands

Facility:
Name: Maastricht Universitair Medisch Centrum

Address:
City: Maastricht
Zip: 6229 HX
Country: Netherlands

Facility:
Name: Radboud Universitair Medisch Centrum

Address:
City: Nijmegen
Zip: 6525 GA
Country: Netherlands

Facility:
Name: St. Antonius Ziekenhuis - Ziekenhuis Utrecht

Address:
City: Utrecht
Zip: 3543 AZ
Country: Netherlands

Facility:
Name: Universitair Medisch Centrum Utrecht

Address:
City: Utrecht
Zip: 3584 CX
Country: Netherlands

Facility:
Name: Instytut MSF

Address:
City: Lodz
Zip: 90-302
Country: Poland

Facility:
Name: MS Pnuemed - Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna

Address:
City: Lublin
Zip: 20-064
Country: Poland

Facility:
Name: Specjalistyczna Praktyka Lekarska Slawomir Mandziuk

Address:
City: Lublin
Zip: 20-093
Country: Poland

Facility:
Name: Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy

Address:
City: Otwock
Zip: 05-400
Country: Poland

Facility:
Name: Mruk-Med I Sp. z o.o.

Address:
City: Rzeszow
Zip: 35-922
Country: Poland

Facility:
Name: Pratia Poznan

Address:
City: Skorzewo
Zip: 60-185
Country: Poland

Facility:
Name: Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu

Address:
City: Torun
Zip: 87-100
Country: Poland

Facility:
Name: Wojskowy Instytut Medyczny

Address:
City: Warsaw
Zip: 04-349
Country: Poland

Facility:
Name: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta)

Address:
City: Almada
Zip: 2805-267
Country: Portugal

Facility:
Name: Unidade Local de Saude de Braga, E. P. E (Hospital de Braga)

Address:
City: Braga
Zip: 4710-243
Country: Portugal

Facility:
Name: Instituto Portugues de Oncologia de Coimbra Francisco Gentil

Address:
City: Coimbra
Zip: 3000-075
Country: Portugal

Facility:
Name: Unidade Local de Saude de Coimbra

Address:
City: Coimbra
Zip: 3000-075
Country: Portugal

Facility:
Name: Unidade Local de Saude do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimaraes)

Address:
City: Guimaraes
Zip: 4835-044
Country: Portugal

Facility:
Name: Instituto Portugues De Oncologia De Lisboa Francisco Gentil

Address:
City: Lisbon
Zip: 1099-023
Country: Portugal

Facility:
Name: The Champalimaud Centre for the Unknown

Address:
City: Lisbon
Zip: 1400-038
Country: Portugal

Facility:
Name: Hospital CUF Descobertas

Address:
City: Lisbon
Zip: 1998-018
Country: Portugal

Facility:
Name: Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo)

Address:
City: Loures
Zip: 2674-514
Country: Portugal

Facility:
Name: Hospital CUF Porto

Address:
City: Porto
Zip: 14341
Country: Portugal

Facility:
Name: Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio

Address:
City: Porto
Zip: 4099-001
Country: Portugal

Facility:
Name: Instituto Portugues de Oncologia do Porto Francisco Gentil

Address:
City: Porto
Zip: 4200-072
Country: Portugal

Facility:
Name: Unidade Local de Saude de Entre Douro e Vouga, E. P. E

Address:
City: Santa Maria Da Feira
Zip: 4520-211
Country: Portugal

Facility:
Name: Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal)

Address:
City: Setubal
Zip: 2910-443
Country: Portugal

Facility:
Name: Unidade Local de Saude de Gaia/Espinho, E. P. E

Address:
City: Vila Nova de Gaia
Zip: 4434-502
Country: Portugal

Facility:
Name: Puerto Rico Medical Research Center

Address:
City: San Juan
Zip: 00919
Country: Puerto Rico

Facility:
Name: Fundacion de Investigacion de Diego Clinical Research

Address:
City: San Juan
Zip: 00927
Country: Puerto Rico

Facility:
Name: PanOncology Trials - Rio Piedras Medical Center

Address:
City: San Juan
Zip: 00935
Country: Puerto Rico

Facility:
Name: Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare

Address:
City: Baia Mare
Zip: 430031
Country: Romania

Facility:
Name: SC Policlinica de Diagnostic Rapid SA

Address:
City: Brașov
Zip: 500152
Country: Romania

Facility:
Name: Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu

Address:
City: Bucharest
Zip: 022328
Country: Romania

Facility:
Name: Centrul Oncologic Sanador

Address:
City: București
Zip: 010991
Country: Romania

Facility:
Name: Institutul Oncologic Prof. Dr. Ion Chiricuta

Address:
City: Cluj-Napoca
Zip: 400015
Country: Romania

Facility:
Name: Medisprof

Address:
City: Cluj-Napoca
Zip: 400641
Country: Romania

Facility:
Name: Oncolab Craiova

Address:
City: Craiova
Zip: 200385
Country: Romania

Facility:
Name: Centrul de Oncologie Sf Nectarie

Address:
City: Craiova
Zip: 200746
Country: Romania

Facility:
Name: Centrul de Oncologie Euroclinic

Address:
City: Iasi
Zip: 700106
Country: Romania

Facility:
Name: Ovidius Clinical Hospital

Address:
City: Ovidiu
Zip: 905900
Country: Romania

Facility:
Name: SC OncoMed SRL

Address:
City: Timisoara
Zip: 300239
Country: Romania

Facility:
Name: Oncocenter - Oncologie Clinica

Address:
City: Timișoara
Zip: 300166
Country: Romania

Facility:
Name: Evimed Oncology Clinic

Address:
City: Chelyabinsk
Zip: 454048
Country: Russian Federation

Facility:
Name: "Budgetary Healthcare Institution of the Udmurt Republic "Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr

Address:
City: Izhevsk
Zip: 426067
Country: Russian Federation

Facility:
Name: "Regional Budgetary Healthcare Institution "G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center" of the Healthcare C

Address:
City: Kislino Village
Zip: 305524
Country: Russian Federation

Facility:
Name: VitaMed - Moscow

Address:
City: Moscow
Zip: 121309
Country: Russian Federation

Facility:
Name: University Headache Clinic

Address:
City: Moscow
Zip: 121467
Country: Russian Federation

Facility:
Name: State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center

Address:
City: Nizhniy Novgorod
Zip: 603006
Country: Russian Federation

Facility:
Name: "Limited Liability Company Medical Sanitary Unit "Clinicist-Clinic Pretor""

Address:
City: Novosibirsk
Zip: 630099
Country: Russian Federation

Facility:
Name: "Budgetary Healthcare Institution of Omsk region "Clinical Oncologic Dispensary""

Address:
City: Omsk
Zip: 644013
Country: Russian Federation

Facility:
Name: EuroCityClinic LLC

Address:
City: Saint Petersburg
Zip: 197022
Country: Russian Federation

Facility:
Name: Saint Petersburg Clinical Scientific & Practical Center for Specialized Types of Medical Care (Oncology)

Address:
City: Saint Petersburg
Zip: 197758
Country: Russian Federation

Facility:
Name: "Federal State Budgetary Institution "Influenza Research Institute named after N.N. A.A. Smorodintsev" of the Ministry of Health

Address:
City: Saint-Petersburg
Zip: 197376
Country: Russian Federation

Facility:
Name: National Cancer Centre Singapore

Address:
City: Singapore
Zip: 168583
Country: Singapore

Facility:
Name: Raffles Hospital

Address:
City: Singapore
Zip: 188770
Country: Singapore

Facility:
Name: Icon Cancer Centre Farrer Park

Address:
City: Singapore
Zip: 217562
Country: Singapore

Facility:
Name: Oncocare Cancer Centre

Address:
City: Singapore
Zip: 258499
Country: Singapore

Facility:
Name: Parkway Cancer Centre - Gleneagles Hospital

Address:
City: Singapore
Zip: 258500
Country: Singapore

Facility:
Name: Complejo Hospitalario Universitario A Coruna

Address:
City: A Coruna
Zip: 15006
Country: Spain

Facility:
Name: Hospital General Universitario Dr. Balmis

Address:
City: Alicante
Zip: 3010
Country: Spain

Facility:
Name: Hospital Germans Trias i Pujol

Address:
City: Badalona
Zip: 08916
Country: Spain

Facility:
Name: Hospital Universitario Cruces

Address:
City: Barakaldo
Zip: 48903
Country: Spain

Facility:
Name: Hospital del Mar - Parc de Salut Mar

Address:
City: Barcelona
Zip: 08003
Country: Spain

Facility:
Name: Hospital Universitari Dexeus

Address:
City: Barcelona
Zip: 08028
Country: Spain

Facility:
Name: Hospital Universitari Vall dHebron

Address:
City: Barcelona
Zip: 08035
Country: Spain

Facility:
Name: Hospital Clinic de Barcelona

Address:
City: Barcelona
Zip: 08036
Country: Spain

Facility:
Name: Hospital Universitario Reina Sofia

Address:
City: Cordoba
Zip: 14004
Country: Spain

Facility:
Name: Institut Catala dOncologia Girona (ICO Girona)

Address:
City: Girona
Zip: 17007
Country: Spain

Facility:
Name: Hospital Universitario Virgen de las Nieves

Address:
City: Granada
Zip: 18014
Country: Spain

Facility:
Name: Complejo Hospitalario Universitario Insular Materno Infantil

Address:
City: Las Palmas de Gran Canaria
Zip: 35016
Country: Spain

Facility:
Name: Hospital de Leon

Address:
City: Leon
Zip: 24008
Country: Spain

Facility:
Name: Hospital Universitario Lucus Augusti

Address:
City: Lugo
Zip: 27003
Country: Spain

Facility:
Name: Hospital Beata Maria Ana

Address:
City: Madrid
Zip: 28007
Country: Spain

Facility:
Name: Clinica Universidad de Navarra - Madrid

Address:
City: Madrid
Zip: 28027
Country: Spain

Facility:
Name: Hospital Universitario Ramon y Cajal

Address:
City: Madrid
Zip: 28034
Country: Spain

Facility:
Name: Hospital Clinico San Carlos

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario Fundacion Jimenez Diaz

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario 12 de Octubre

Address:
City: Madrid
Zip: 28041
Country: Spain

Facility:
Name: Hospital Universitario Puerta de Hierro - Majadahonda

Address:
City: Majadahonda
Zip: 28222
Country: Spain

Facility:
Name: Hospital Regional Universitario de Malaga - Hospital Civil

Address:
City: Malaga
Zip: 29009
Country: Spain

Facility:
Name: Hospital Universitario Son Espases

Address:
City: Palma de Mallorca
Zip: 07120
Country: Spain

Facility:
Name: Hospital Universitario Marques de Valdecilla

Address:
City: Santander
Zip: 39008
Country: Spain

Facility:
Name: Consorci Hospital General Universitari de Valencia

Address:
City: Valencia
Zip: 46014
Country: Spain

Facility:
Name: Hospital Universitari i Politecnic La Fe

Address:
City: Valencia
Zip: 46026
Country: Spain

Facility:
Name: Hospital Clinico Universitario Lozano Blesa

Address:
City: Zaragoza
Zip: 50009
Country: Spain

Facility:
Name: Universitatsspital Basel

Address:
City: Basel
Zip: 4031
Country: Switzerland

Facility:
Name: Kantonsspital Winterthur

Address:
City: Winterthur
Zip: 8401
Country: Switzerland

Facility:
Name: University Hospital Birmingham NHS Foundation Trust

Address:
City: Birmingham
Zip: B15 2WB
Country: United Kingdom

Facility:
Name: NHS Lothian

Address:
City: Edinburgh
Zip: EH4 2XU
Country: United Kingdom

Facility:
Name: NHS Greater Glasgow and Clyde

Address:
City: Glasgow
Zip: G12 0XH
Country: United Kingdom

Facility:
Name: University Hospitals of Leicester NHS Trust

Address:
City: Leicester
Zip: LE1 5WW
Country: United Kingdom

Facility:
Name: The Christie NHS Foundation Trust

Address:
City: Manchester
Zip: M20 4BX
Country: United Kingdom

Start date: April 1, 2021

Completion date: December 31, 2024

Lead sponsor:
Agency: Mirati Therapeutics Inc.
Agency class: Industry

Source: Mirati Therapeutics Inc.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT04685135
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
https://www.BMSStudyConnect.com