Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination With Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007)

Trial Title: Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination With Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007)

NCT ID: NCT05226598

Condition: Metastatic Non-Small Cell Lung Cancer

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Paclitaxel
Albumin-Bound Paclitaxel
Carboplatin
Pembrolizumab
Pemetrexed

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: Triple (Participant, Investigator, Outcomes Assessor)

Intervention:

Intervention type: Biological
Intervention name: Pembrolizumab/Vibostolimab
Description: Co-formulation of pembrolizumab 200 mg/20 mL vial and vibostolimab 200 mg administered as IV infusion for up to 35 administrations
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: MK-7684A

Intervention type: Drug
Intervention name: Carboplatin
Description: Carboplatin 10 mg/ml administered as IV infusion Q3W for 4 administrations
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: PARAPLATIN®, Paraplatin NovaPlus ®

Intervention type: Drug
Intervention name: Cisplatin
Description: Cisplatin 1 mg/ml administered as IV infusion Q3W for 4 administrations
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: Platinol-AQ®

Intervention type: Drug
Intervention name: Paclitaxel
Description: Paclitaxel 6mg/ml administered as IV infusion Q3W for 4 administrations
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: TAXOL®, ONXOL®

Intervention type: Drug
Intervention name: Nab-paclitaxel
Description: Nab-paclitaxel 100 mg/vial administered as IV infusion Days 1, 8, and 15 of each 21-day cycle for 4 administrations
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: ABRAXANE®

Intervention type: Drug
Intervention name: Pemetrexed
Description: Pemetrexed 500 mg/vial administered as IV infusion Q3W until progression, intolerable adverse event (AE), or participant or physician decision
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed
Arm group label: Pembrolizumab/Vibostolimab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: Alimta®

Intervention type: Biological
Intervention name: Pembrolizumab
Description: Pembrolizumab 25 mg/mL administered as IV infusion Q3W for up to 35 administrations
Arm group label: Pembrolizumab + Carboplatin + Cisplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed

Other name: MK-3475, KEYTRUDA®

Summary: The primary hypothesis is that pembrolizumab/vibostolimab (MK-7684A) in combination with chemotherapy is superior to pembrolizumab in combination with chemotherapy with respect to overall survival (OS) in treatment-naïve metastatic participants with non-small cell lung cancer (NSCLC).

Criteria for eligibility:
Criteria:
The main inclusion and exclusion criteria include but are not limited to the following: Inclusion Criteria: - A histologically or cytologically confirmed diagnosis of Stage IV squamous or non-squamous NSCLC - Has not received prior systemic treatment for metastatic NSCLC - Has measurable disease based on RECIST 1.1, as determined by the local site assessment - Has a life expectancy of at least 3 months - Males: Use contraception unless confirmed to be azoospermic; Females: Women of childbearing potential use highly effective contraceptive method Exclusion Criteria: - Known additional malignancy that is progressing or has required active treatment within the past 3 years - Known active central nervous system (CNS) metastases and/or carcinomatous meningitis - Severe hypersensitivity to MK-7684, MK-7684A, pembrolizumab, chemotherapy components, and/or any of its excipients - Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days before the first dose of study medication - Active autoimmune disease that has required systemic treatment in past 2 years, except replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) - History of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease - Has an active infection requiring systemic therapy - Has a known history of human immunodeficiency virus (HIV), Hepatitis B or/and Hepatitis C virus - Received prior systemic anticancer therapy for metastatic disease - Received a live or live attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines are allowed - History of allogeneic tissue/solid organ transplant - Is unable to interrupt aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other than an aspirin dose ≤1.3 g/day, for a 5-day period (8-day period for long-acting agents, such as piroxicam) - Is unable or unwilling to take folic acid or vitamin B12 supplementation - Currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks before the first dose of study intervention

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: UCHealth Memorial Hospital-Heme Onc ( Site 0003)

Address:
City: Colorado Springs
Zip: 80909
Country: United States

Facility:
Name: University of Colorado Health - Harmony-Cancer Care and Hematology - Ft. Collins ( Site 0031)

Address:
City: Fort Collins
Zip: 80528
Country: United States

Facility:
Name: Mayo Clinic in Florida ( Site 0022)

Address:
City: Jacksonville
Zip: 32224
Country: United States

Facility:
Name: Mount Sinai Hospital ( Site 0011)

Address:
City: Chicago
Zip: 60608
Country: United States

Facility:
Name: University of Chicago Medical Center ( Site 0015)

Address:
City: Chicago
Zip: 60637
Country: United States

Facility:
Name: New England Cancer Specialists ( Site 0008)

Address:
City: Scarborough
Zip: 04074
Country: United States

Facility:
Name: Cancer and Hematology Centers of Western Michigan ( Site 0002)

Address:
City: Grand Rapids
Zip: 49503
Country: United States

Facility:
Name: Mayo Clinic in Rochester, Minnesota ( Site 0030)

Address:
City: Rochester
Zip: 55905
Country: United States

Facility:
Name: Stony Brook University-Cancer Center ( Site 0013)

Address:
City: Stony Brook
Zip: 11794
Country: United States

Facility:
Name: Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0012)

Address:
City: Lancaster
Zip: 17604
Country: United States

Facility:
Name: Charleston Oncology ( Site 0019)

Address:
City: Charleston
Zip: 29414
Country: United States

Facility:
Name: University of Virginia Cancer Center ( Site 0018)

Address:
City: Charlottesville
Zip: 22903
Country: United States

Facility:
Name: Centro de Oncología e Investigación de Buenos Aires ( Site 0203)

Address:
City: Berazategui
Zip: B1884BBF
Country: Argentina

Facility:
Name: Instituto de Investigaciones Clínicas Mar del Plata ( Site 0204)

Address:
City: Mar del Plata
Zip: B7600FZO
Country: Argentina

Facility:
Name: Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0209)

Address:
City: ABB
Zip: C1199ABB
Country: Argentina

Facility:
Name: Centro de Educación Médica e Investigaciones Clínicas (CEMIC)-Medical Oncology ( Site 0202)

Address:
City: Buenos Aires
Zip: C1431FWO
Country: Argentina

Facility:
Name: Sanatorio Parque ( Site 0205)

Address:
City: Rosario
Zip: 2000
Country: Argentina

Facility:
Name: Hospital Provincial del Centenario ( Site 0212)

Address:
City: Rosario
Zip: 2002
Country: Argentina

Facility:
Name: Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0206)

Address:
City: La Rioja
Zip: F5300COE
Country: Argentina

Facility:
Name: Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0705)

Address:
City: Linz
Zip: 4020
Country: Austria

Facility:
Name: Kepler Universitätsklinikum ( Site 0707)

Address:
City: Linz
Zip: 4021
Country: Austria

Facility:
Name: Medizinische Universität Graz ( Site 0704)

Address:
City: Graz
Zip: 8036
Country: Austria

Facility:
Name: Medizinische Universitaet Innsbruck ( Site 0703)

Address:
City: Innsbruck
Zip: 6020
Country: Austria

Facility:
Name: Klinik Penzing-2. Lungenabteilung ( Site 0702)

Address:
City: Vienna
Zip: 1140
Country: Austria

Facility:
Name: Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0701)

Address:
City: Wien
Zip: 1210
Country: Austria

Facility:
Name: Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0403)

Address:
City: Natal
Zip: 59075-740
Country: Brazil

Facility:
Name: Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0405)

Address:
City: Porto Alegre
Zip: 91350-200
Country: Brazil

Facility:
Name: Clínica de Oncologia Reichow ( Site 0407)

Address:
City: Blumenau
Zip: 89010-340
Country: Brazil

Facility:
Name: Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA ( Site 0406)

Address:
City: Rio de Janeiro
Zip: 20230-130
Country: Brazil

Facility:
Name: Hospital Paulistano ( Site 0401)

Address:
City: Sao Paulo
Zip: 01321-001
Country: Brazil

Facility:
Name: James Lind Centro de Investigación del Cáncer ( Site 0502)

Address:
City: Temuco
Zip: 4800827
Country: Chile

Facility:
Name: CIDO SpA-Oncology ( Site 0508)

Address:
City: Temuco
Zip: 4810148
Country: Chile

Facility:
Name: Biocenter ( Site 0514)

Address:
City: Concepción
Zip: 4070196
Country: Chile

Facility:
Name: FALP-UIDO ( Site 0505)

Address:
City: Santiago
Zip: 6900941
Country: Chile

Facility:
Name: Centro de Oncología de Precisión ( Site 0515)

Address:
City: Santiago
Zip: 7560908
Country: Chile

Facility:
Name: Bradfordhill ( Site 0510)

Address:
City: Santiago
Zip: 8420383
Country: Chile

Facility:
Name: ONCOCENTRO APYS-ACEREY ( Site 0503)

Address:
City: Viña del Mar
Zip: 2520598
Country: Chile

Facility:
Name: Centro de Investigación Oncológica del Norte ( Site 0504)

Address:
City: Antofagasta
Zip: 1240000
Country: Chile

Facility:
Name: Anhui Provincil Hospital South District-Respiratory Medicine Dept ( Site 2619)

Address:
City: Hefei
Zip: 230036
Country: China

Facility:
Name: Beijing Cancer hospital-Thoracic Cancer Department A ( Site 2602)

Address:
City: Beijing
Zip: 100142
Country: China

Facility:
Name: Fujian Provincial Cancer Hospital-oncology department ( Site 2621)

Address:
City: Fuzhou
Zip: 350014
Country: China

Facility:
Name: The First Affiliated hospital of Xiamen University ( Site 2626)

Address:
City: Xiamen City
Zip: 361003
Country: China

Facility:
Name: Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine (

Address:
City: Guangzhou
Zip: 510515
Country: China

Facility:
Name: Harbin Medical University Cancer Hospital-oncology of department ( Site 2604)

Address:
City: Harbin
Zip: 150000
Country: China

Facility:
Name: Henan Cancer Hospital ( Site 2608)

Address:
City: Zhengzhou
Zip: 450000
Country: China

Facility:
Name: Wuhan Union Hospital Cancer Center-Cancer Center ( Site 2618)

Address:
City: Wuhan
Zip: 430022
Country: China

Facility:
Name: Tongji Hospital Tongji Medical,Science & Technology ( Site 2617)

Address:
City: Wuhan
Zip: 430030
Country: China

Facility:
Name: Xiangya Hospital Central South University-Oncology department ( Site 2627)

Address:
City: Changsha
Zip: 410008
Country: China

Facility:
Name: The Second Xiangya Hospital of Central South University ( Site 2623)

Address:
City: Changsha
Zip: 410011
Country: China

Facility:
Name: Hunan Cancer Hospital ( Site 2622)

Address:
City: Changsha
Zip: 410013
Country: China

Facility:
Name: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Oncology (

Address:
City: Nanjing
Zip: 210000
Country: China

Facility:
Name: The First Affiliated Hospital of Nanchang University-Respiratory Medicine Department ( Site 2625)

Address:
City: Nanchang
Zip: 330006
Country: China

Facility:
Name: The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2624)

Address:
City: Nanchang
Zip: 330006
Country: China

Facility:
Name: Jilin Cancer Hospital-oncology department ( Site 2603)

Address:
City: Changchun
Zip: 132000
Country: China

Facility:
Name: The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 2607)

Address:
City: Xi'an
Zip: 710061
Country: China

Facility:
Name: Shandong Cancer Hospital-Oncology Department ( Site 2630)

Address:
City: Jinan
Zip: 250117
Country: China

Facility:
Name: Fudan University Shanghai Cancer Center ( Site 2616)

Address:
City: Shanghai
Zip: 200032
Country: China

Facility:
Name: Shanghai Pulmonary Hospital-Oncology Department ( Site 2601)

Address:
City: Shanghai
Zip: 200433
Country: China

Facility:
Name: West China Hospital of Sichuan University ( Site 2610)

Address:
City: Cheng Du
Zip: 610041
Country: China

Facility:
Name: Sichuan Cancer hospital ( Site 2628)

Address:
City: Chengdu
Zip: 610041
Country: China

Facility:
Name: The Second People's Hospital of Yibin ( Site 2629)

Address:
City: Yibin
Zip: 644000
Country: China

Facility:
Name: Tianjin Medical University Cancer Institute and Hospital-lung cancer ( Site 2606)

Address:
City: Tianjin
Zip: 300060
Country: China

Facility:
Name: The First Affiliated Hospital, Zhejiang University-Respiratory Department ( Site 2613)

Address:
City: Hangzhou
Zip: 310003
Country: China

Facility:
Name: Sir Run Run Shaw Hospital-Medical Oncology ( Site 2615)

Address:
City: Hangzhou
Zip: 310016
Country: China

Facility:
Name: Zhejiang Cancer Hospital-Oncology ( Site 2612)

Address:
City: Hangzhou
Zip: 310022
Country: China

Facility:
Name: The Second Affiliated hospital of Zhejiang University school of medicine-Respiratory Medicine ( Site

Address:
City: Hangzhou
Zip: 310052
Country: China

Facility:
Name: Fundación Colombiana de Cancerología Clínica Vida ( Site 0603)

Address:
City: Medellin
Zip: 050030
Country: Colombia

Facility:
Name: Sociedad De Oncologia Y Hematologia Del Cesar ( Site 0606)

Address:
City: Valledupar
Zip: 200001
Country: Colombia

Facility:
Name: Oncomedica S.A.-Oncomedica S.A ( Site 0609)

Address:
City: Montería
Zip: 230001
Country: Colombia

Facility:
Name: Administradora Country S.A. - Clinica del Country ( Site 0601)

Address:
City: Bogotá
Zip: 110221
Country: Colombia

Facility:
Name: Oncologos del Occidente ( Site 0608)

Address:
City: Pereira
Zip: 660001
Country: Colombia

Facility:
Name: CENTRE HOSPITALIER REGIONAL D'ORLEANS-Service de Pneumologie ( Site 0806)

Address:
City: Orléans
Zip: 45067
Country: France

Facility:
Name: Centre Hospitalier d'Annecy ( Site 0807)

Address:
City: Epagny Metz-Tessy
Zip: 74370
Country: France

Facility:
Name: Institut de Cancérologie de l'Ouest ( Site 0802)

Address:
City: ANGERS cedex 02
Zip: 49055
Country: France

Facility:
Name: Centre Hospitalier Regional Universitaire de Lille - Hôpital-Service de pneumologie et oncologie th

Address:
City: Lille
Zip: 59037
Country: France

Facility:
Name: CENTRE LEON BERARD ( Site 0803)

Address:
City: Lyon CEDEX 08
Zip: 69373
Country: France

Facility:
Name: HIA Sainte Anne ( Site 0804)

Address:
City: Toulon
Zip: 83800 Cedex 9
Country: France

Facility:
Name: Centre Hospitalier d'Avignon ( Site 0810)

Address:
City: Avignon
Zip: 84000
Country: France

Facility:
Name: UKGM Gießen/Marburg-Medical Clinic V ( Site 0912)

Address:
City: Gießen
Zip: 35392
Country: Germany

Facility:
Name: GEFOS Gesellschaft f. onkologische Studien ( Site 0909)

Address:
City: Dortmund
Zip: 44263
Country: Germany

Facility:
Name: Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 0902)

Address:
City: Lübeck
Zip: 23538
Country: Germany

Facility:
Name: SRH Wald-Klinikum Gera ( Site 0911)

Address:
City: Gera
Zip: 07548
Country: Germany

Facility:
Name: Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 0913

Address:
City: Berlin
Zip: 13353
Country: Germany

Facility:
Name: Rambam Health Care Campus-Oncology ( Site 1303)

Address:
City: Haifa
Zip: 3109601
Country: Israel

Facility:
Name: Shaare Zedek Medical Center-Oncology ( Site 1306)

Address:
City: Jerusalem
Zip: 9013102
Country: Israel

Facility:
Name: Meir Medical Center-oncology ( Site 1301)

Address:
City: Kfar Saba
Zip: 4428164
Country: Israel

Facility:
Name: Sheba Medical Center-ONCOLOGY ( Site 1302)

Address:
City: Ramat Gan
Zip: 5265601
Country: Israel

Facility:
Name: Sourasky Medical Center-Oncology ( Site 1305)

Address:
City: Tel Aviv
Zip: 6423906
Country: Israel

Facility:
Name: National Hospital Organization Shikoku Cancer Center ( Site 2414)

Address:
City: Matsuyama
Zip: 791-0280
Country: Japan

Facility:
Name: Ehime University Hospital ( Site 2411)

Address:
City: Toon
Zip: 791-0295
Country: Japan

Facility:
Name: Hyogo Cancer Center-Thoracic Oncology ( Site 2409)

Address:
City: Akashi
Zip: 673-8558
Country: Japan

Facility:
Name: Kanazawa University Hospital ( Site 2407)

Address:
City: Kanazawa
Zip: 920-8641
Country: Japan

Facility:
Name: Kanagawa cancer center-Department of Thoracic Oncology ( Site 2405)

Address:
City: Yokohama
Zip: 241-8515
Country: Japan

Facility:
Name: Miyagi Cancer Center ( Site 2401)

Address:
City: Natori
Zip: 981-1293
Country: Japan

Facility:
Name: Kansai Medical University Hospital ( Site 2415)

Address:
City: Hirakata
Zip: 573-1191
Country: Japan

Facility:
Name: Saitama Prefectural Cancer Center ( Site 2406)

Address:
City: Ina-machi
Zip: 362-0806
Country: Japan

Facility:
Name: Shizuoka Cancer Center ( Site 2408)

Address:
City: Nagaizumi
Zip: 411-8777
Country: Japan

Facility:
Name: Japanese Foundation for Cancer Research ( Site 2402)

Address:
City: Koto
Zip: 135-8550
Country: Japan

Facility:
Name: Showa University Hospital ( Site 2403)

Address:
City: Shinagawa
Zip: 1428666
Country: Japan

Facility:
Name: National Hospital Organization Kyushu Medical Center ( Site 2413)

Address:
City: Fukuoka
Zip: 810-8563
Country: Japan

Facility:
Name: National Hospital Organization Kyushu Cancer Center ( Site 2412)

Address:
City: Fukuoka
Zip: 811-1395
Country: Japan

Facility:
Name: Okayama University Hospital ( Site 2410)

Address:
City: Okayama
Zip: 700-8558
Country: Japan

Facility:
Name: Nippon Medical School Hospital ( Site 2404)

Address:
City: Tokyo
Zip: 113-8603
Country: Japan

Facility:
Name: Chonnam National University Hwasun Hospital-Pulmonology ( Site 2201)

Address:
City: Hwasun
Zip: 58128
Country: Korea, Republic of

Facility:
Name: Pusan National University Hospital ( Site 2205)

Address:
City: Busan
Zip: 49241
Country: Korea, Republic of

Facility:
Name: Asan Medical Center ( Site 2206)

Address:
City: Songpa-gu
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2202)

Address:
City: Deagu
Zip: 41404
Country: Korea, Republic of

Facility:
Name: Chungnam national university hospital-Department of Internal Medicine ( Site 2203)

Address:
City: Daejeon
Zip: 35015
Country: Korea, Republic of

Facility:
Name: Korea University Guro Hospital-Internal Medicine ( Site 2204)

Address:
City: Seoul
Country: Korea, Republic of

Facility:
Name: CENTRO DE INFUSION E INVESTIGACION ONCOLOGIA DE SALTILLO S.C. ( Site 0304)

Address:
City: Saltillo
Zip: 25279
Country: Mexico

Facility:
Name: Alivia Clínica de Alta Especialidad ( Site 0310)

Address:
City: Ciudad de Mexico
Zip: 06760
Country: Mexico

Facility:
Name: Arké SMO S.A. de C.V. ( Site 0301)

Address:
City: Mexico
Zip: 06700
Country: Mexico

Facility:
Name: Hospital Civil Fray Antonio Alcalde ( Site 0307)

Address:
City: Guadalajara
Zip: 44280
Country: Mexico

Facility:
Name: Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1903)

Address:
City: Bydgoszcz
Zip: 85-796
Country: Poland

Facility:
Name: Centrum Medyczne Ostrobramska NZOZ Magodent ( Site 1908)

Address:
City: Warsaw
Zip: 04-125
Country: Poland

Facility:
Name: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1904)

Address:
City: Przemysl
Zip: 37-700
Country: Poland

Facility:
Name: Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 1906)

Address:
City: Prabuty
Zip: 82-550
Country: Poland

Facility:
Name: Centrum Pulmonologii i Torakochirurgii w Bystrej ( Site 1907)

Address:
City: Bystra
Zip: 43-360
Country: Poland

Facility:
Name: Przychodnia Lekarska KOMED ( Site 1902)

Address:
City: Konin
Zip: 62-500
Country: Poland

Facility:
Name: Med-Polonia Sp. z o. o. ( Site 1909)

Address:
City: Poznan
Zip: 60-693
Country: Poland

Facility:
Name: CHUAC-Hospital Teresa Herrera-MEDICAL ONCOLOGY ( Site 1106)

Address:
City: A Coruña
Zip: 15006
Country: Spain

Facility:
Name: Hospital Insular de Gran Canaria-Oncology ( Site 1102)

Address:
City: Las Palmas de Gran Canaria
Zip: 35001
Country: Spain

Facility:
Name: Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1101)

Address:
City: Barcelona
Zip: 08035
Country: Spain

Facility:
Name: Hospital Clinico San Carlos-Oncology Department ( Site 1107)

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 1103)

Address:
City: Sevilla
Zip: 41009
Country: Spain

Facility:
Name: Hospital Clínico Universitario Lozano Blesa-Oncology ( Site 1105)

Address:
City: Zaragoza
Zip: 50009
Country: Spain

Facility:
Name: Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 2254)

Address:
City: Kaohsiung
Zip: 807
Country: Taiwan

Facility:
Name: China Medical University Hospital ( Site 2253)

Address:
City: Taichung
Zip: 40447
Country: Taiwan

Facility:
Name: NATIONAL CHENG-KUNG UNI. HOSP. ( Site 2252)

Address:
City: Tainan
Zip: 704
Country: Taiwan

Facility:
Name: National Taiwan University Hospital-Oncology ( Site 2255)

Address:
City: Taipei
Zip: 100
Country: Taiwan

Facility:
Name: Chang Gung Medical Foundation-Linkou Branch ( Site 2251)

Address:
City: Taoyuan
Zip: 333
Country: Taiwan

Facility:
Name: Faculty of Medicine - Khon Kaen University ( Site 2303)

Address:
City: Muang
Zip: 40002
Country: Thailand

Facility:
Name: Faculty of Medicine Siriraj Hospital ( Site 2304)

Address:
City: Bangkok
Zip: 10700
Country: Thailand

Facility:
Name: Chulabhorn Hospital ( Site 2305)

Address:
City: Lak Si
Zip: 10210
Country: Thailand

Facility:
Name: Songklanagarind hospital ( Site 2302)

Address:
City: Hatyai
Zip: 90110
Country: Thailand

Facility:
Name: Maharaj Nakorn Chiang Mai Hospital-Chiang Mai Clinical Trial Unit (CM-CTU) ( Site 2301)

Address:
City: Chiang Mai
Zip: 50200
Country: Thailand

Facility:
Name: Acibadem Altunizade Hospital-Oncology ( Site 1207)

Address:
City: Üsküdar / Stanbul
Zip: 34662
Country: Turkey

Facility:
Name: Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1208)

Address:
City: Adana
Zip: 01250
Country: Turkey

Facility:
Name: Hacettepe Universitesi-oncology hospital ( Site 1202)

Address:
City: Ankara
Zip: 06230
Country: Turkey

Facility:
Name: Liv Hospital Ankara-Oncology ( Site 1205)

Address:
City: Ankara
Zip: 06680
Country: Turkey

Facility:
Name: Ankara City Hospital ( Site 1204)

Address:
City: Ankara
Zip: 06800
Country: Turkey

Facility:
Name: Trakya University-Medical Oncology ( Site 1203)

Address:
City: Edirne
Zip: 22030
Country: Turkey

Facility:
Name: TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1209)

Address:
City: Istanbul
Zip: 34722
Country: Turkey

Facility:
Name: Umraniye Training and Research Hospital-medical oncology ( Site 1206)

Address:
City: Istanbul
Zip: 34766
Country: Turkey

Facility:
Name: Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 1502)

Address:
City: Leicester
Country: United Kingdom

Facility:
Name: Chelsea and Westminster Hospital NHS Foundation Trust-Research and Development ( Site 1501)

Address:
City: London
Zip: SW10 9NH
Country: United Kingdom

Facility:
Name: University College London Hospital-Cancer Clinical Trials Unit ( Site 1509)

Address:
City: London-Camden
Zip: NW1 2PG
Country: United Kingdom

Facility:
Name: St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1506)

Address:
City: London
Zip: EC1A 7BE
Country: United Kingdom

Start date: March 24, 2022

Completion date: September 27, 2027

Lead sponsor:
Agency: Merck Sharp & Dohme LLC
Agency class: Industry

Source: Merck Sharp & Dohme LLC

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05226598
https://www.merckclinicaltrials.com
https://trialstransparency.merckclinicaltrials.com/Study.aspx?id=7684A-007&kw=7684A-007