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Trial Title: Tislelizumab Plus Lenvatinib in Stage III-IV RCC

NCT ID: NCT05485883

Condition: Advanced Kidney Cancer

Conditions: Official terms:
Kidney Neoplasms
Lenvatinib
Tislelizumab

Conditions: Keywords:
Tislelizumab Lenvatinib

Study type: Interventional

Study phase: Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Tislelizumab Lenvatinib
Description: Patients will receive treatment with Tislelizumab in combination with Lenvatinib every 3 weeks unitl tumor progression or serious side effects
Arm group label: Advanced Renal Cell

Summary: This is a phase II study to determine the efficacy and safety of Tislelizumab when given in combination with Lenvatinib as treatment for patients with the advanced kidney cancer . Patients will receive treatment with Tislelizumab in combination with Lenvatinib every 3 weeks unitl tumor progression or serious side effects

Detailed description: This is a phase II study to determine the efficacy and safety of Tislelizumab when given in combination with lenvatinib as treatment for patients with the advanced kidney cancer . Patients will receive treatment with Tislelizumab in combination with lenvatinib every 3 weeks unitl tumor progression or serious side effects.The primary outcome measure was PFS

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Willing and able to provide written informed consent - Age ≥ 18 years - Subjects with pathologically and radiologically confirmed renal cell carcinoma: Stage III/IV - There are no suspected brain metastases - There are lesions that can be measured by imaging - Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1 - Organ function level must meet the following requirements: Hematological indexes: neutrophil count >= 1.5x10^9/L, platelet count >= 100x10^9/L, hemoglobin >= 9.0 g/dl (can be maintained by blood transfusion); Liver function: total bilirubin <=1.5 ULN, alanine aminotransferase and aspartate aminotransferase <=1.5 ULN - Women were required to use an effective contraceptive method for three months after the end of the study, and men were required to consent to use an effective contraceptive method with their spouse during and for three months after the end of the study - The subjects volunteered to join the study, signed informed consent, and had good compliance with follow-up Exclusion Criteria: - Prior treatment with radiation, chemotherapy, long-term or high-dose hormone therapy, or immune checkpoint inhibitors - Previous or concurrent other malignancy - Previous PD-L1 or PD-L1 treatment, or allergy to PD-L1 - History of primary immunodeficiency - Active, known or suspected autoimmune diseases - Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation - Pregnant or lactating female patients; - Untreated acute or chronic active hepatitis B or hepatitis C infection. Under the condition of monitoring the virus copy number of patients receiving antiviral treatment, doctors can judge whether they are in line with the patients' individual conditions; - Have a clear history of active tuberculosis; - Participating in other clinical researchers; - Men with reproductive capacity or women who are likely to become pregnant do not take reliable contraceptive measures; - Uncontrolled concurrent diseases, including but not limited to: HIV infected (HIV antibody positive); Severe infection in active stage or poorly controlled; Evidence of serious or uncontrollable systemic diseases (such as severe mental, neurological, epilepsy or dementia, unstable or uncompensated respiratory, cardiovascular, liver or kidney diseases, uncontrolled hypertension [i.e. hypertension greater than or equal to CTCAE grade 2 after drug treatment]); Patients with active bleeding or new thrombotic disease

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Changyi Quan

Address:
City: Tianjin
Zip: 300211
Country: China

Status: Recruiting

Contact:
Last name: Changyi Quan, PhD

Phone: 13388067990
Email: 345920147@qq.com

Start date: July 1, 2022

Completion date: December 31, 2025

Lead sponsor:
Agency: Tianjin Medical University Second Hospital
Agency class: Other

Source: Tianjin Medical University Second Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05485883

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