Trial Title:
The PLATON Network
NCT ID:
NCT05489250
Condition:
Hepatocellular Cancer
Cholangiocarcinoma
Gallbladder Cancer
Pancreatic Cancer
Oesophageal Cancer
Stomach Cancer
Conditions: Official terms:
Pancreatic Neoplasms
Cholangiocarcinoma
Gallbladder Neoplasms
Stomach Neoplasms
Liver Neoplasms
Carcinoma, Hepatocellular
Conditions: Keywords:
Gastric cancer
Individualized cancer therapy
Targetable mutations
NGS
Hepatocellular Cancer
Cholangiocarcinoma
Gallbladder Cancer
Pancreatic Cancer
Oesophageal Cancer
Stomach Cancer
Platform-Design
Biobanking
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Summary:
The PLATON Network study is designed to elevate personalized therapy based on genomic
tumor profiles in gastrointestinal cancer patients. Hereby, PLATON's study-design focuses
on the patient's tumor molecular profiling. Within the network a web application will be
developed to link clinical investigators and information on study sites, cancer patients
and genetic alteration data, as well as available clinical trials at PLATON's study
sites.
Detailed description:
The PLATON Network is established as permanent open, multicenter, prospective, cohort
study of patients with gastrointestinal cancer. The study design includes a
study-specific biobank and a shared platform infrastructure for associated sub-studies
and analysis projects.
Within PLATON results of genetic tests of different research projects like the PLATON
pilot-study (NCT04484636) as well as Next-generation deep sequencing (NGS) according to
local protocols will be documented - compiling genomic tumor-profiles including tumor
mutational burden (TMB) and microsatellite instability (MSI).
The PLATON Network infrastructure is designed to increase the likelihood of treating the
patients with an individualized therapy in available clinical studies. Therefore,
molecular profiling must go hand in hand with inter-linking physicians and increasing
inter-centre transparency. The feasibility of this approach will be tested in the PLATON
Network, keeping in mind the vision of cancer patients receiving the best available,
scientifically founded, biomarker-based care, tailored to his or her individual needs.
Criteria for eligibility:
Study pop:
The PLATON Network and its associated pilot study (clinicaltrials.gov:. NCT04484636)
enrolls national-wide participants of both sexes and ages over 18 years. All participants
are patients diagnosed with hepatocellular cancer (HCC) or intra-/extrahepatic
cholangiocellular carcinoma (CCA) or gallbladder carcinoma (GBCA) or pancreatic cancer
(PanCa) or esophagogastric cancer (EC/GC). At the time of enrolment life expectancy is at
least 6 months and no local curative therapy is available.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Histologically confirmed diagnosis of hepatocellular carcinoma or intra-
cholangiocarcinoma, extrahepatic cholangiocarcinoma or gallbladder carcinoma or
pancreatic ductal adenocarcinoma or esophagogastric adenocarcinoma in the advanced
setting (adjuvant or neoadjuvant therapy is allowed if completed 6 months prior to
enrolment) and no local curative therapy available
- Standard first line therapy is planned, or patient is currently receiving first-line
therapy
- Available tumor-genomic profile ( ≥50-gene panel assay; approved and assessed by
central review), unless central tumor genomic profiling is done within a sub-study
- ECOG 0-2
- Life expectancy ≥ 6 months
Exclusion Criteria:
- Not able to understand all implications of study participation
- No written informed consent
- Age < 18 years
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
KHNW Frankfurt
Address:
City:
Frankfurt
Zip:
60488
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Thorsten Götze, Prof.
Contact backup:
Last name:
Ulli Bankstahl
Investigator:
Last name:
Thorsten Götze, Prof.
Email:
Principal Investigator
Investigator:
Last name:
Timursah Habibzade, Dr.
Email:
Sub-Investigator
Facility:
Name:
Friedrich-Ebert-Krankenhaus Neumünster
Address:
City:
Neumünster
Zip:
24534
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Siegfried Haas, Dr.
Contact backup:
Last name:
Stefan Mahlmann, Dr.
Investigator:
Last name:
Kristin Bajorat
Email:
Sub-Investigator
Investigator:
Last name:
Paul Zimmermann, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Karsten Hamann, Dr.
Email:
Sub-Investigator
Facility:
Name:
HELIOS Klinikum Bad Saarow
Address:
City:
Bad Saarow
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Daniel Pink, Dr. med.
Contact backup:
Last name:
Simone Micheel
Facility:
Name:
Evangelisches Waldkrankenhaus Spandau
Address:
City:
Berlin
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Silke Polata, Dr
Contact backup:
Last name:
Ute Moritz
Investigator:
Last name:
Silke Polata, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Kristin Lindemann, Dr.
Email:
Sub-Investigator
Facility:
Name:
MVZ Oskar-Helene-Heim Berlin
Address:
City:
Berlin
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Markus Schuler, Dr. med.
Contact backup:
Last name:
Leffers Elvira
Investigator:
Last name:
Markus Schuler, Dr. med.
Email:
Principal Investigator
Investigator:
Last name:
Philipp Kiewe, Dr. med.
Email:
Sub-Investigator
Facility:
Name:
Augusta-Kranken-Anstalt Bochum
Address:
City:
Bochum
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Dirk Behringer, Prof. Dr.
Contact backup:
Last name:
Dorothee Henzler
Investigator:
Last name:
Dirk Behringer, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Annette Nolte, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Iris Dieck-Stiller
Email:
Sub-Investigator
Investigator:
Last name:
Anna E Zdebik
Email:
Sub-Investigator
Investigator:
Last name:
Tanja Woiwod
Email:
Sub-Investigator
Investigator:
Last name:
Stefan Lukic
Email:
Sub-Investigator
Facility:
Name:
Bochum Uni
Address:
City:
Bochum
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Michael Pohl, Dr.
Contact backup:
Last name:
Julia Buß
Investigator:
Last name:
Michael Pohl, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Deepak Vangala, Dr.
Email:
Sub-Investigator
Facility:
Name:
Klinikum Chemnitz
Address:
City:
Chemnitz
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Jack Chater, Dr.
Contact backup:
Last name:
Katja Schaarschmidt
Investigator:
Last name:
Jack Chater, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Hagen Rudolph, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Ilja Kubisch, Dr.
Email:
Sub-Investigator
Facility:
Name:
GEFOS - Gesellschaft für onkologische Studien Dortmund
Address:
City:
Dortmund
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Clemens Schulte, Dr.
Contact backup:
Last name:
Monika Ludwig, Dr.
Investigator:
Last name:
Clemens Schulte, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Jörg Lipke, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Christiane Dr. Christiane Bernhardt, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Daniela Collette
Email:
Sub-Investigator
Investigator:
Last name:
Sandra Ketzler-Henkel
Email:
Sub-Investigator
Facility:
Name:
Onkozentrum Dresden
Address:
City:
Dresden
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Steffen Dörfel
Contact backup:
Last name:
Franziska Schwarzbach
Investigator:
Last name:
Steffen Dörfel
Email:
Principal Investigator
Investigator:
Last name:
Thomas Göhler, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Sebastian Thiele, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Susann Melzer, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Thomas Boldt
Email:
Sub-Investigator
Facility:
Name:
Ev. Kliniken Essen-Mitte, Klinik für Internistische Onkologie
Address:
City:
Essen
Zip:
45136
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Stefan Pluntke, MD
Investigator:
Last name:
Stefan Pluntke, MD
Email:
Principal Investigator
Facility:
Name:
MVZ Onkologische Kooperation Harz
Address:
City:
Goslar
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Mark-Oliver Zahn, Dr.
Contact backup:
Last name:
Alexandra Hess
Investigator:
Last name:
Mark-Oliver Zahn, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Timo Kambach, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Bijan Zomorodbakhsch, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Martin Stolze, Dr.
Email:
Sub-Investigator
Facility:
Name:
Universitätsklinikum Halle (Saale)
Address:
City:
Halle
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Patrick Michl, Prof. Dr.
Contact backup:
Last name:
Susanne Behl
Investigator:
Last name:
Patrick Michl, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Petra Büchner-Steudel
Email:
Sub-Investigator
Investigator:
Last name:
Sebastian Krug
Email:
Sub-Investigator
Investigator:
Last name:
Nora Schweitzer
Email:
Sub-Investigator
Facility:
Name:
Hamburg Onkologische Schwerpunktpraxis Eppendorf
Address:
City:
Hamburg
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Eray Goekkurt
Contact backup:
Last name:
Beate Poppinga-Scholz
Investigator:
Last name:
Alexander Stein, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Eray Goekkurt, Dr.
Email:
Principal Investigator
Facility:
Name:
St. Anna Hospital Herne
Address:
City:
Herne
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Vera Heuer, Dr.
Contact backup:
Last name:
Monika Stache
Investigator:
Last name:
Vera Heuer, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Christoph Dobrescu
Email:
Sub-Investigator
Investigator:
Last name:
Tjorven K Förster
Email:
Sub-Investigator
Investigator:
Last name:
Philipp J Haubold
Email:
Sub-Investigator
Investigator:
Last name:
Martin Jazra, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Viktor Rempel, Dr.
Email:
Sub-Investigator
Facility:
Name:
Ortenau Klinikum Lahr-Ettenheim
Address:
City:
Lahr
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Jean-Charles Moulin, Dr.
Contact backup:
Last name:
Kerstin Riedel
Investigator:
Last name:
Jean-Charles Moulin, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Oliver Delic, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Angela Nieder, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Oliver Schmah, Dr.
Email:
Sub-Investigator
Facility:
Name:
ÜBAG - MVZ Dr. Vehling-Kaiser GmbH
Address:
City:
Landshut
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Michael Sohm, Dr.
Contact backup:
Last name:
Ana Hoffmann, Dr.
Investigator:
Last name:
Michael Sohm, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Ursula Vehling-Kaiser, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Florian Kaiser, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Franziskus Finsterwalder, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Mike Haberkorn
Email:
Sub-Investigator
Investigator:
Last name:
Maximilian Müller, Dr.
Email:
Sub-Investigator
Facility:
Name:
Langen, Gemeinschaftspraxis für Hämatologie und Onkologie
Address:
City:
Langen
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Andreas Köhler, Dr.
Contact backup:
Last name:
Beate Jung
Investigator:
Last name:
Andreas Köhler, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Roswitha Fuchs, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Katharina Girod, Dr.
Email:
Sub-Investigator
Facility:
Name:
Studienzentrum UnterEms
Address:
City:
Leer
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Lothar Müller, Dr.
Contact backup:
Last name:
Christine Strohschnieder
Investigator:
Last name:
Lothar Müller, Dr.
Email:
Principal Investigator
Facility:
Name:
Klinikum Lippe
Address:
City:
Lemgo
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Frank Hartmann, Prof. Dr.
Contact backup:
Last name:
Melanie Kriete
Investigator:
Last name:
Frank Hartmann, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Christian Constantin, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Sarunas Bagdonas, Dr.
Email:
Sub-Investigator
Facility:
Name:
Klinikum Ludwigsburg
Address:
City:
Ludwigsburg
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Stefan Angermeier, Dr.
Contact backup:
Last name:
Juliane Behn
Investigator:
Last name:
Stefan Angermeier, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Matthias Ulmer, Dr.
Email:
Sub-Investigator
Facility:
Name:
Klinik München-Bogenhausen
Address:
City:
München
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Martin Fuchs, Dr.
Contact backup:
Last name:
Bettina Huß
Investigator:
Last name:
Martin Fuchs, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Irene Klingenberg, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Jael Nisenbaum, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Fabian Hartmann, Dr.
Email:
Sub-Investigator
Facility:
Name:
Münster, Gemeinschaftspraxis für Hämatologie und Onkologie
Address:
City:
Münster
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Rüdiger Liersch, Dr.
Contact backup:
Last name:
Martina Ester
Investigator:
Last name:
Rüdiger Liersch, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Christian Lerchenüller, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Ralf Bieker, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Karsten Kratz-Albers, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Holger Timmer, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Daniela Schüler, Dr.
Email:
Sub-Investigator
Facility:
Name:
Medius Klinik Osterfildern-Ruit
Address:
City:
Ostfildern
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Bodo Klump, Prof. Dr.
Contact backup:
Last name:
Chistine Neumann
Investigator:
Last name:
Bodo Klump, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Alberta-May Daraban-Brixner, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Nikolai Schuelper, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Karin Waibel, Dr.
Email:
Sub-Investigator
Facility:
Name:
Krankenhaus Barmherzige Brüder
Address:
City:
Regensburg
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Nicolas Moosmann, Dr.
Contact backup:
Last name:
Christiane Reinert
Investigator:
Last name:
Nicolas Moosmann, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Anke Schlenska-Lange, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Nadia Maguire, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
V. Berberich, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Jan Braess, Prof. Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Susanne Thalmeier, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Heribert Stauder, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Michael Schenk, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Bernhard Heilmeier, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Bernard Braun, Dr.
Email:
Sub-Investigator
Facility:
Name:
Klinikum Rheine, Mathias-Spital Rheine
Address:
City:
Rheine
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Sebastian Broeckling, Dr.
Contact backup:
Last name:
Kerstin Vehring
Investigator:
Last name:
Sebastian Broeckling, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Stefan Zicholl, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Antonia Hansmeier, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Guido Bisping, Dr.
Email:
Sub-Investigator
Facility:
Name:
CaritasKlinikum Saarbrücken
Address:
City:
Saarbrücken
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Manfred Lutz, Prof. Dr.
Contact backup:
Last name:
Ulrike Schilling
Investigator:
Last name:
Manfred Lutz, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Michael Clemens, Prof. Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Anca A Cura, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Jérôme Schwingel
Email:
Sub-Investigator
Facility:
Name:
Onkologie Bodensee
Address:
City:
Singen
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Thomas Fietz, Dr.
Contact backup:
Last name:
Karin Kingerter
Investigator:
Last name:
Thomas Fietz, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Christian Hertkorn, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Niels Steinebrunner, Dr.
Email:
Sub-Investigator
Facility:
Name:
Marien Hospital Witten
Address:
City:
Witten
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Matthias Zeth, Dr.
Contact backup:
Last name:
Katja Fritz
Investigator:
Last name:
Matthias Zeth, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Metin Senkal, Prof. Dr.
Email:
Sub-Investigator
Facility:
Name:
Klinikum Wolfsburg
Address:
City:
Wolfsburg
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Nils Homann, Prof. Dr.
Contact backup:
Last name:
Jeannette Wertmann
Investigator:
Last name:
Nils Homann, Prof. Dr.
Email:
Principal Investigator
Investigator:
Last name:
Steffen Neumann, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Janine Markgraf
Email:
Sub-Investigator
Investigator:
Last name:
Alexander Behrens, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Ulrike Weber
Email:
Sub-Investigator
Facility:
Name:
Onkologisches Zentrum Wolfsburg-Helmstedt MVZ GmbH
Address:
City:
Wolfsburg
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Thomas Gabrysiak, Dr.
Contact backup:
Last name:
Carina Kupke
Investigator:
Last name:
Thomas Gabrysiak, Dr.
Email:
Principal Investigator
Investigator:
Last name:
Joachim Haessner, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Katrin Heine, Dr.
Email:
Sub-Investigator
Investigator:
Last name:
Jens Kersten
Email:
Sub-Investigator
Start date:
October 28, 2020
Completion date:
May 31, 2032
Lead sponsor:
Agency:
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Agency class:
Other
Source:
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05489250
https://platon-network.de/
http://platonwebapp.de
https://asp.interactive-systems.de/cgi-bin/WebObjects/ST50-productive-DataCapture.woa/wa/choose?customer=TGO
