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Trial Title:
Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study
NCT ID:
NCT05491616
Condition:
Esophageal Cancer
Conditions: Official terms:
Esophageal Neoplasms
Nivolumab
Immune Checkpoint Inhibitors
Conditions: Keywords:
immunotherapy
Nivolumab
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Nivolumab
Description:
In this SANO-3 study, patients will receive Nivolumab at 480mg Q4W starting 10-14 weeks
after nCRT (i.e., when cCR has been established) until disease progression or
unacceptable toxicity, for a maximum duration of 1 year.
Arm group label:
Nivolumab q4w
Other name:
Immune Checkpoint Inhibitor
Summary:
In an effort to prevent surgery in selected patients with esophageal cancer, the SANO-2
study offers active surveillance to patients with clinically complete response (cCR)
after neoadjuvant chemoradiation (nCRT). Some of these patients will never develop
locoregional and/or distant recurrence of disease (persistent cCR). However, two-thirds
of the patients that undergo active surveillance still get disease recurrence. This can
be locoregional regrowth or distant metastases. To increase the efficacy of active
surveillance (reduce the proportion of patients that need surgery) and improve survival,
effective systemic maintenance therapy is needed. The CheckMate 577 randomized, placebo
controlled, clinical trial showed that Nivolumab increases disease free survival in
patients after nCRT and esophagectomy.
Objective: To assess the efficacy of nivolumab during active surveillance in patients
with cCR after neoadjuvant chemoradiation for esophageal cancer
Detailed description:
The rationale of maintenance nivolumab in patients with cCR undergoing active
surveillance is to decrease the risk for disease recurrence and improve survival as well
as to optimize the chance for having an organ sparing treatment. In this non-randomized
phase II study we will assess the efficacy of maintenance nivolumab in patients who are
undergoing active surveillance after nCRT in the context of the SANO-2 trial: the SANO-3
study. The SANO-3 study aims to identify a new indication for immunotherapy in primary
esophageal cancer: patients who have been identified as a clinical complete responders
10-14 weeks after nCRT can be included. This subgroup of patients will not undergo
standard surgery but instead continue with active surveillance after nCRT when they opt
for participation in the SANO-2 trial.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Age ≥18
2. Written informed consent and ability to understand the nature of the study and the
study-related procedures and to comply with them
3. Histologically proven, resectable adenocarcinoma or squamous cell carcinoma of the
esophagus or GEJ (gastroesophageal junction) according to the UICC TNM7 definition.
Tumors of the esophagus and tumors of which the epicentre is within 5 cm of the GEJ
are eligible for inclusion in the trial (Type 1 and Type 2 according to Siewert
classification of esophagogastric adenocarcinoma
4. Pre-treatment stage cT2-4aN0-2M0 disease. In case of stage cT4a, the possibility for
a curative resection has to be explicitly verified by the multidisciplinary tumor
board
5. nCRT (CROSS regimen) completed, i.e. all radiotherapy fractions administered.
6. Complete clinical response 10-14 weeks after nCRT as determined by endoscopy with
biopsies, EUS with FNA and PET/CT scanning
7. No prior cytotoxic chemotherapy other than as part of the neoadjuvant chemoradiation
(CROSS)
8. Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
9. Adequate cardiac function (cardiac function tests such as echocardiography only
necessary in symptomatic patients).
10. Adequate respiratory function (pulmonary function tests only necessary in
symptomatic patients).
11. Adequate bone marrow function (White Blood Cells >2x10^9/l; Haemoglobin >6,2mmol/L;
platelets >100x10^9/l). In the event of transfusions, the last red blood cell
transfusion should be more than 2 weeks before inclusion.
12. Adequate renal function (Glomerular Filtration Rate >40 ml/min) or Serum creatinine
<=1.5 x upper limit of normal (ULN)
13. Adequate liver function (AST and ALT < 3.0 x ULN; Total bilirubin < 1.5 x ULN
(except participants with Gilbert Syndrome who may have a total bilirubin level of <
3.0 x ULN)
14. Women of child-bearing potential must have a negative serum pregnancy test during
screening period
15. Patients must be willing to use adequate contraception during the study and for 3
months after the end of the study.
Exclusion Criteria:
1. Language difficulty, dementia or altered mental status prohibiting the understanding
and giving of informed consent and to complete quality of life questionnaires;
2. Patients who were treated with definitive chemoradiotherapy
3. Patients who were unable to complete all radiotherapy fractions of the nCRT
4. No cCR at 10-14 weeks
5. Esophageal cancer evaluated as not curatively-resectable by the multidisciplinary
tumour board, for instance because ingrowth in the trachea, aorta or vertebra (cT4b)
6. Gastric carcinoma
7. Clinically significant (active) cardiac disease (e.g. symptomatic coronary artery
disease or myocardial infarction within last 12 months)
8. Clinically significant lung disease (Forced Expiratory Volume in one second (FEV1)
9. Pregnant and lactating women, or patients of reproductive potential who are not
using effective birth control methods. If barrier contraceptives are used, they must
be continued by both sexes throughout the study.
10. Participation, current or during the last 30 days prior to informed consent, in
another intervention trial with interference to the chemotherapeutic or
chemoradiotherapeutic intervention of this study.
11. Expected lack of compliance with the protocol
12. Refusal to undergo further active surveillance (i.e., opting for esophageal
resection)
13. Prior malignancy active within the previous 2 years except for locally curable
cancers that have been apparently cured or successfully resected, such as basal or
squamous cell skin cancer, superficial bladder cancer, or GC, or carcinoma in situ
of the prostate, cervix, or breast
14. Participants with an active, known or suspected autoimmune disease. Participants
with type I diabetes mellitus, hypothyroidism only requiring hormone replacement,
skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic
treatment, or conditions not expected to recur in the absence of an external trigger
are permitted to enrol.
15. Participants with a condition requiring systemic treatment with either
corticosteroids (> 10 mg daily prednisone equivalents for adults, or > 0.25 mg/kg
daily prednisone equivalent for adolescent) or other immunosuppressive medications
within 14 days of study treatment. Inhaled or topical steroids and adrenal
replacement doses > 10 mg daily prednisone equivalents for adults, or > 0.25 mg/kg
daily prednisone equivalent for adolescents are permitted, in the absence of active
autoimmune disease.
16. Participants who received prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2,
anti-CD137, or anti-CTLA-4 antibody, or any other antibody or drug specifically
targeting T-cell co-stimulation or checkpoint pathways
17. Anti-tumor treatment other than as part of neoadjuvant chemoradiation (CROSS) within
28 days of first administration of study treatment
18. Known history of positive test for human immunodeficiency virus (HIV) or known
acquired immunodeficiency syndrome (AIDS).
19. Any positive test result for hepatitis B virus or hepatitis C virus indicating
presence of virus, e.g, hepatitis B surface antigen (HBsAg, Australia antigen)
positive, or hepatitis C antibody (anti-HCV) positive (except if HCV-RNA negative)
20. Participants must not have received a live / attenuated vaccine within 30 days of
first treatment.
21. History of severe hypersensitivity reactions to other monoclonal antibodies
22. History of allergy or hypersensitivity to study drug components
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Erasmus MC
Address:
City:
Rotterdam
Zip:
3015GD
Country:
Netherlands
Status:
Recruiting
Contact:
Last name:
Jessie Huizer, Drs
Phone:
0107034523
Email:
t.j.huizer@erasmusmc.nl
Start date:
September 29, 2022
Completion date:
October 2026
Lead sponsor:
Agency:
Erasmus Medical Center
Agency class:
Other
Source:
Erasmus Medical Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05491616