Trial Title:
Signatures of Response and Resistance to Mosunetuzomab in Follicular Lymphomas (FL)
NCT ID:
NCT05529524
Condition:
Follicular Lymphoma
Conditions: Official terms:
Lymphoma
Lymphoma, Follicular
Conditions: Keywords:
Follicular Lymphoma
Mosunetuzomab
Resistance
CD20-CD3
Bispecific antibodies
Neoplasms
Lymphatic Diseases
Immunoproliferative Disorders
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Summary:
Mosunetuzumab is a T-cell bispecific antibody targeting CD20 and CD3 aiming to redirect T
cells to engage and eliminate malignant B cells. Bispecific antibodies (BsAb) are a
promising treatment option which can induce long-term responses in refractory and
relapsed B cell lymphoma patients. However, the factors determining the quality and
duration of responses are poorly understood.
Detailed description:
the objective is to produce a collection of great scientific interest for lymphoma
research from CELESTIMO's clinical trial patients' samples to increase knowledge of
treatment with mosunetuzumab's for patients with follicular lymphoma (FL).
study population involves patients participating to CELESTIMO study in France. 10 sites
are expected in this biobanking protocol study
Biological samples will collected as part of routine care (tissue and blood already
sampled in routine and/or CELESTIMO study) at screening, at C4, at C12 or at progressive
disease/relapse.
Criteria for eligibility:
Study pop:
patients who participate to CELESTIMO study (NCT04712097)
Sampling method:
Non-Probability Sample
Criteria:
patients who participate to CELESTIMO study (NCT04712097)
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Centre Hospitalier de La Cote Basque; Hematologie
Address:
City:
Bayonne
Zip:
64109
Country:
France
Status:
Recruiting
Contact:
Last name:
Jean-Baptiste Robin, MD
Phone:
+33559443832
Email:
jbrobin@ch-cotebasque.fr
Investigator:
Last name:
Jean-Baptiste Robin, MD
Email:
Principal Investigator
Facility:
Name:
Hopital Claude Huriez; Hematologie
Address:
City:
Lille
Zip:
59037
Country:
France
Status:
Recruiting
Contact:
Last name:
FRANCK MORSCHHAUSER, MD
Phone:
+33320444290
Email:
Franck.MORSCHHAUSER@chu-lille.fr
Investigator:
Last name:
FRANCK MORSCHHAUSER, MD
Email:
Principal Investigator
Facility:
Name:
Institut Paoli Calmettes
Address:
City:
Marseille
Zip:
13273
Country:
France
Status:
Recruiting
Contact:
Last name:
Jean Marc Schiano de Colella
Phone:
+33491223569
Email:
schianojm@ipc.unicancer.fr
Investigator:
Last name:
Jean Marc Schiano de Colella, MD
Email:
Principal Investigator
Facility:
Name:
CHU Saint Eloi; Service d'Hématologie Clinique
Address:
City:
Montpellier
Zip:
34295
Country:
France
Status:
Recruiting
Contact:
Last name:
Guillaume Cartron, MD
Phone:
+33467338355
Email:
g-cartron@chu-montpellier.fr
Investigator:
Last name:
Guillaume Cartron, MD
Email:
Principal Investigator
Facility:
Name:
CHU NANTES - Hôtel Dieu; Service d'Hematologie Clinique
Address:
City:
Nantes cedex 1
Zip:
44000
Country:
France
Status:
Recruiting
Contact:
Last name:
Benoit Tessoulin, MD
Phone:
+33240087766
Email:
benoit.tessoulin@chu-nantes.fr
Investigator:
Last name:
Benoit Tessoulin, MD
Email:
Principal Investigator
Facility:
Name:
CHU de Nîmes - Hôpital Carémeau
Address:
City:
Nîmes
Zip:
30029
Country:
France
Status:
Recruiting
Contact:
Last name:
Agathe Waultier-Rascalou, MD
Phone:
+33466683702
Email:
agathe.waultier.rascalou@chu-nimes.fr
Investigator:
Last name:
Agathe Waultier-Rascalou, MD
Email:
Principal Investigator
Facility:
Name:
Hopital Saint Antoine; Hematologie Clinique
Address:
City:
Paris
Zip:
75012
Country:
France
Status:
Recruiting
Contact:
Last name:
Remy DULERY, MD
Phone:
+330149282162
Email:
remy.dulery@aphp.fr
Investigator:
Last name:
Remy DULERY, MD
Email:
Principal Investigator
Facility:
Name:
Hopital De La Miletrie; Hematologie Et Oncologie Medicale
Address:
City:
Poitiers
Zip:
86021
Country:
France
Status:
Recruiting
Contact:
Last name:
Stéphanie Guidez, MD
Phone:
+33549444689
Email:
stephanie.guidez@chu-poitiers.fr
Investigator:
Last name:
Stéphanie Guidez, MD
Email:
Principal Investigator
Facility:
Name:
CHU Pontchaillou
Address:
City:
Rennes
Zip:
35033
Country:
France
Status:
Recruiting
Contact:
Last name:
Roch Houot, MD
Phone:
+33299284161
Email:
roch.houot@chu-rennes.fr
Investigator:
Last name:
Roch Houot, MD
Email:
Principal Investigator
Start date:
November 7, 2022
Completion date:
September 1, 2024
Lead sponsor:
Agency:
The Lymphoma Academic Research Organisation
Agency class:
Other
Collaborator:
Agency:
Roche Pharma AG
Agency class:
Industry
Source:
The Lymphoma Academic Research Organisation
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05529524
