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Trial Title:
Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block as Postoperative Analgesia in Patients Undergoing Abdominal Cancer Surgery.
NCT ID:
NCT05533424
Condition:
Abdominal Cancer
Conditions: Official terms:
Abdominal Neoplasms
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Unknown status
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Other
Masking:
Single (Outcomes Assessor)
Intervention:
Intervention type:
Other
Intervention name:
quadratus lumborum
Description:
the patient will be positioned supine with lateral tilt , and the transducer was placed
at the level of the anterior superior iliac spine and moved cranially until the three
abdominal wall muscles were clearly identified. The external oblique muscle was followed
posterolaterally until its posterior border was visualized . The probe was tilted down to
identify a bright hyperechoic line that represented the middle layer of the thoracolumbar
fascia. The needle will be inserted in plane from anterolateral to posteromedial. The
needle tip was placed between the thoracolumbar fascia and the QL muscle, and after
negative aspiration, the correct position of the needle was proved by injection of 5 mL
of normal saline to confirm the space with a hypoechoic image and hydrodissection. An
injection of 20 mL of 0.25% bupivacaine was applied
Arm group label:
Group quadratus lumborum
Intervention type:
Other
Intervention name:
transversus abdominis plane
Description:
the probe will located between the iliac crest and the lower costal margin in the
anterior axillary line at the level of umbilicus, and the layers of abdominal wall were
identified (external oblique, internal oblique, and transverse abdominis muscles).
In-plane technique was used and the tip of the needle was inserted between the internal
oblique and transverse abdominis muscles. After negative aspiration (to exclude
intravascular injection), 20 mL of 0.25% bupivacaine was injected. The same technique
will be performed on the other side
Arm group label:
Group transversus abdominis plane
Summary:
Abdominal surgery is usually associated with severe postoperative pain. The transverse
abdominal plane (TAP) block is considered an effective means for pain control in such
cases. The quadratus lumborum (QL) block is another option for the management of
postoperative pain.
The aim of this study is to evaluate the efficacy and safety of quadrates lumborum blocks
and Transversus abdominis plane blocks for pain management after abdominal cancer
surgery.
Detailed description:
Postoperative pain is severe in patients undergoing abdominal surgery, and severe pain
not only affects the rate of recovery of patients but also induces a series of
pathophysiological reactions. Therefore, it is very important for perioperative patients
to have a safe and effective pain management model. Although classic postoperative
analgesia methods can provide effective pain relief after surgery, their administration
has a well-defined risk of side effects. Recently, with the rise in enhanced recovery
after surgery, nerve blocks have become the key link in multimodal analgesic regimes.
As effective constituents of multimode analgesia, quadratus lumborum (QL) block and
transversus abdominis plane (TAP) block are mainly used for postoperative analgesia in
abdominal surgery.
Aim of this study is to compare between the analgesic effecacy of quadrates lumborum
block and transverses abdominal plane block
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients included in the study, aged 20-60 years,
- with ASA Physical Status Class I and II,
- scheduled for abdominal cancer surgery under general anesthesia
Exclusion Criteria:
- infection at injection site,
- allergy to local anesthetics,
- coagulation disorders,
- physical or mental diseases which could interfere with the evaluation of pain scores
- kidney failure or liver failure.
Gender:
All
Minimum age:
20 Years
Maximum age:
80 Years
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Nevert Adel Abdel Ghaffar
Address:
City:
Mansoura
Country:
Egypt
Status:
Recruiting
Contact:
Last name:
Nevert A Abdel Ghaffar, MD
Phone:
01223947977
Email:
nevertadel@mans.edu.eg
Contact backup:
Last name:
Yahya M Wahba, MD
Phone:
01211313554
Email:
yahyawahba@ymail.com
Investigator:
Last name:
nevert a abdel ghaffar, assist prof
Email:
Sub-Investigator
Investigator:
Last name:
ghada f amer, assist prof
Email:
Principal Investigator
Start date:
September 1, 2022
Completion date:
December 15, 2023
Lead sponsor:
Agency:
Mansoura University
Agency class:
Other
Source:
Mansoura University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05533424
