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Trial Title:
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of AIS With Active Cancer
NCT ID:
NCT05553990
Condition:
Ischemic Stroke, Acute
Tumor Progression
Conditions: Official terms:
Stroke
Ischemic Stroke
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Other
Intervention name:
intestinal flora disturbance
Description:
To observe the clinical prognosis of stroke patients complicated with tumor after
enterobacterial disorder
Arm group label:
Acute ischemic stroke with active tumor
Summary:
Explore with active cancer patients with acute ischemic stroke in the human body
characteristic microorganism disorder to clinical prognosis of the predictive value of
the secondary objective: to observe with active cancer patients with acute ischemic
stroke in the body of microorganisms and their serological indexes change law of
exploration condition change related biomarkers of microscopic objects group based on the
human body.
Detailed description:
investigators recently found that changes in gut microbiota in patients with ischemic
stroke are associated with the development of disease. However, there are few studies on
the correlation between ischemic stroke with cancer and human microbiome and metabolites
Whether the human microbiome and its metabolites are associated with the prognosis of
such patients remains to be investigated. Therefore, this study hypothesized that
structural changes in the human microbiome and its metabolites in patients with acute
ischemic stroke with active cancer were associated with stroke severity and disease
recovery Therefore, this topic proposed by collecting active follow-up cancer of acute
ischemic stroke patients after admission and oral swabs Excrement and urine and blood
samples, and based on the queue, follow-up analysis of the human microbiome dynamic
change rule and the prognosis of patients with cancer of the acute ischemic stroke
correlation, activity, further explore the secondary prevention of stroke management
strategy based on the human microbiome.
Criteria for eligibility:
Study pop:
Acute ischemic stroke with active tumor
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- 1: It meets the diagnostic criteria for acute ischemic stroke
2: Age ≥ 18 years
3: The onset time is less than or equal to 2 weeks
4: Diagnosis of cancer before stroke onset or during hospitalization and active
cancer (failure to meet clinical criteria for cure, or discovery of recurrence or
metastasis)
5: Sign an informed consent form, provide relevant medical history information and
provide biological specimens
Exclusion Criteria:
- 1: Previous history of disabling stroke (pre-onset mRS ≥2)
2: Primary central nervous system tumor or hematologic system tumor
3: The cancer meets the criteria for clinical cure and has not recurred or
metastasized for more than 5 years
4: Antibiotics, prebiotics/probiotics taken within 1 month
5: Patients who cannot have stool specimens within 4 days of admission
Gender:
All
Minimum age:
18 Years
Maximum age:
85 Years
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Nanfang Hospital,Southern Medical University
Address:
City:
Guangzhou
Country:
China
Status:
Recruiting
Contact:
Last name:
jia yin
Phone:
13802964883
Email:
jiajiayin@139.com
Start date:
June 7, 2020
Completion date:
April 1, 2025
Lead sponsor:
Agency:
Nanfang Hospital, Southern Medical University
Agency class:
Other
Source:
Nanfang Hospital, Southern Medical University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05553990
