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Trial Title:
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
NCT ID:
NCT05558111
Condition:
Orthotopic Neobladder
Conditions: Keywords:
Orthotopic neobladder
Functional magnetic resonance imaging
Neuroimaging Study
Lower urinary tract function
Bladder cancer
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Cross-Sectional
Summary:
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after
radical cystectomy.In recent years, functional imaging studies have revealed brain
regions related to urinary system function, but brain activity of lower urinary tract
function in neobladder patients is still unclear.The aim of this study is to explore the
brain activity of urination intention and self-controlled urination behavior in patients
with orthotopic sigmoid neobladder by task-state functional magnetic resonance imaging
(fMRI).
Criteria for eligibility:
Study pop:
Patients 3 months or more after orthotopic neobladder surgery.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
1. Being right-handed;
2. 3 months or more after operation;
3. No contraindications to fMIR examination;
4. Voluntarily sign informed consent.
Exclusion Criteria:
1. History of bladder radiotherapy;
2. History of prostate cancer;
3. Suffering from diseases affecting abdominal pressure;
4. History of abnormal brain anatomy, craniocerebral surgery, craniocerebral tumor, and
craniocerebral radiotherapy;
5. History of mental disorders, Parkinson's disease, Alzheimer's disease, epilepsy,
cerebral infarction, cerebral hemorrhage;
6. Claustrophobia or carrying metal implants that are not suitable for fMRI
examination;
7. Diseases affecting lower urinary tract function (such as spinal cord injury,
diabetic peripheral neuropathy, etc.);
8. Urethral stricture;
9. Refusing to sign the informed consent form for clinical projects;
10. Other conditions that were not suitable for inclusion according to the
investigator's judgment.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Zhujiang Hospital of Southern Medical University
Address:
City:
Guangzhou
Zip:
510000
Country:
China
Status:
Recruiting
Contact:
Last name:
Chunxiao Liu
Phone:
13302296795
Email:
liuchx888@163.com
Start date:
June 1, 2022
Completion date:
June 1, 2025
Lead sponsor:
Agency:
Zhujiang Hospital
Agency class:
Other
Source:
Zhujiang Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05558111
